Increasing gastric juice pH level prior to anti-Helicobacter pylori therapy may be beneficial to the healing of duodenal ulcers

Fan,Hong-Yun; Wang,Juan; Yan,Guo-Chao; Huo,Xiao-Hui; Mu,Li-Juan; Chu,Jian-Kun; Niu,Wei-Wei; Duan,Zhi-Ying; Ma,Jin-Cheng; Wang,Jing; Wang,Zhi-Yu

doi:10.3892/etm.2013.880

March 2013 Volume 5 Issue 3

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March 2013 Volume 5 Issue 3

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Article

Increasing gastric juice pH level prior to anti-Helicobacter pylori therapy may be beneficial to the healing of duodenal ulcers

Authors:
- Hong-Yun Fan
- Juan Wang
- Guo-Chao Yan
- Xiao-Hui Huo
- Li-Juan Mu
- Jian-Kun Chu
- Wei-Wei Niu
- Zhi-Ying Duan
- Jin-Cheng Ma
- Jing Wang
- Zhi-Yu Wang
View Affiliations / Copyright

Affiliations: Department of Gastroenterology, First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, P.R. China, Department of Biotherapy, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Department of Laboratory, First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, Endoscopy Centre, First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, P.R. China
Pages: 912-916
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Published online on: January 2, 2013

https://doi.org/10.3892/etm.2013.880
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Abstract

The aim of this study was to observe the efficacy of clarithromycin-based triple therapy for Helicobacter pylori (Hp)‑infected duodenal ulcer when combined with different pH levels of gastric juices. A total of 160 patients with Hp-infected duodenal ulcers were randomly allocated into two groups. Patients in the treatment group (n=80) were administered a 20-mg dose of omeprazole twice daily for 1 week and then the treatment and control groups (n=80) received therapy for Hp infection and duodenal ulcers. We observed the ulcer healing stage, the content of anti-Hp IgA in gastric juice and the Hp eradication rate before and after proton pump inhibitor therapy in the two groups. Results revealed that the Hp eradication rate in the treatment group was 93% compared with 81% in the control group, and the difference was statistically significant (P<0.05). The ulcer healing rate in the treatment group was 93%, compared with 70% in the control group (P<0.05). A positive linear correlation was observed between gastric pH and the content of anti-Hp IgA in gastric juice (P<0.05). Increasing gastric pH prior to anti-Hp therapy may be beneficial to the eradication of Hp and for promoting the healing of duodenal ulcers.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Increasing gastric juice pH level prior to anti-Helicobacter pylori therapy may be beneficial to the healing of duodenal ulcers

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