The effects of huperzine A on gastrointestinal acetylcholinesterase activity and motility after single and multiple dosing in mice

  • Authors:
    • Leiming Zhang
    • Yanqin Song
    • Chengwen Lu
    • Jianqiao Zhang
    • Jiani Yuan
    • Tian Wang
    • Fenghua Fu
  • View Affiliations

  • Published online on: January 4, 2013     https://doi.org/10.3892/etm.2013.883
  • Pages: 793-796
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The acetylcholinesterase inhibitor (AChEI), huperzine A has been used in the treatment of the cognitive deterioration associated with Alzheimer's disease (AD). However, the side-effects of huperzine A associated with increased cholinergic activity, particularly in the gastrointestinal system, are evident. It is not yet known how quickly these side-effects become tolerated; this information would provide guidance to doctors on how to use huperzine A so as to attenuate the adverse events. The present study aimed to observe the effects of huperzine A on gastrointestinal motility and acetylcholinesterase (AChE) activity in mice. After oral administration of huperzine A with single and multiple dosing, the gastrointestinal motility and AChE activity of the mice were examined. The results revealed that, following a single dose of huperzine A, the AChE activity in the stomach and duodenum were significantly inhibited and the gastrointestinal motility was significantly increased. However, following multiple doses (7 or 28 doses, one dose per day), no significant changes in the AChE activity and gastrointestinal motility were identified. These findings indicate that the gastrointestinal adverse effects of huperzine A may be well-tolerated relatively quickly and do not recur. Additionally, it suggests that patients with AD are likely to have minimal gastrointestinal side-effects after taking multiple doses of huperzine A.
View Figures
View References

Related Articles

Journal Cover

March 2013
Volume 5 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Song Y, Lu C, Zhang J, Yuan J, Wang T and Fu F: The effects of huperzine A on gastrointestinal acetylcholinesterase activity and motility after single and multiple dosing in mice. Exp Ther Med 5: 793-796, 2013
APA
Zhang, L., Song, Y., Lu, C., Zhang, J., Yuan, J., Wang, T., & Fu, F. (2013). The effects of huperzine A on gastrointestinal acetylcholinesterase activity and motility after single and multiple dosing in mice. Experimental and Therapeutic Medicine, 5, 793-796. https://doi.org/10.3892/etm.2013.883
MLA
Zhang, L., Song, Y., Lu, C., Zhang, J., Yuan, J., Wang, T., Fu, F."The effects of huperzine A on gastrointestinal acetylcholinesterase activity and motility after single and multiple dosing in mice". Experimental and Therapeutic Medicine 5.3 (2013): 793-796.
Chicago
Zhang, L., Song, Y., Lu, C., Zhang, J., Yuan, J., Wang, T., Fu, F."The effects of huperzine A on gastrointestinal acetylcholinesterase activity and motility after single and multiple dosing in mice". Experimental and Therapeutic Medicine 5, no. 3 (2013): 793-796. https://doi.org/10.3892/etm.2013.883