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Article

Ruxolitinib for myelofibrosis

  • Authors:
    • Lian Gu
    • Li Su
    • Qing Chen
    • Juanjuan Xie
    • Guangliang Wu
    • Yan Yan
    • Baoyun Liang
    • Jinjing Tan
    • Nong Tang
  • View Affiliations / Copyright

    Affiliations: Department of Internal Neurology, First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, P.R. China, School of Public Health of Guangxi Medical University, Nanning, Guangxi, P.R. China
  • Pages: 927-931
    |
    Published online on: January 7, 2013
       https://doi.org/10.3892/etm.2013.886
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Abstract

The aim of the present study was to assess the beneficial and harmful effects of ruxolitinib in patients with myelofibrosis (MF). The Cochrane databases, PubMed and Embase were searched for studies published up to October 2012. Randomised controlled trials assessing ruxolitinib versus a placebo or the best available therapy in patients with MF were included. Two trials randomised 528 patients with MF to ruxolitinib versus a placebo or ruxolitinib versus the best available therapy. Compared with the placebo, ruxolitinib had a significant beneficial effect on the proportion of patients that had a reduction in spleen volume of ≥35% at 24 weeks [odds ratio (OR), 109.78; 95% confidence interval (CI), 14.97‑804.78] or an increased overall survival rate (OR, 2.02; 95% CI, 0.99‑4.12). Ruxolitinib significantly increased the risk of several non‑haematological or haematological adverse events, but not the risk of treatment discontinuations (OR, 1.04; 95% CI, 0.50‑2.14). Compared with the best available therapy, ruxolitinib had a significant beneficial effect on the proportion of patients that had a reduction in spleen volume of ≥35% at 24 (OR, 68.45; 95% CI, 4.15‑1129.19) or 48 weeks (OR, 56.20; 95%CI, 3.40‑928.67). Ruxolitinib once again significantly increased the risk of several non‑haematological adverse events, serious adverse events and dose reductions or interruptions (OR, 9.60; 95% CI, 4.66-19.81), but not the risk of treatment discontinuations (OR, 1.54; 95% CI, 0.48‑4.97). In conclusion, based on the trials included in the present study, the use of ruxolitinib is beneficial in the treatment of MF.
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Copy and paste a formatted citation
Spandidos Publications style
Gu L, Su L, Chen Q, Xie J, Wu G, Yan Y, Liang B, Tan J and Tang N: Ruxolitinib for myelofibrosis. Exp Ther Med 5: 927-931, 2013.
APA
Gu, L., Su, L., Chen, Q., Xie, J., Wu, G., Yan, Y. ... Tang, N. (2013). Ruxolitinib for myelofibrosis. Experimental and Therapeutic Medicine, 5, 927-931. https://doi.org/10.3892/etm.2013.886
MLA
Gu, L., Su, L., Chen, Q., Xie, J., Wu, G., Yan, Y., Liang, B., Tan, J., Tang, N."Ruxolitinib for myelofibrosis". Experimental and Therapeutic Medicine 5.3 (2013): 927-931.
Chicago
Gu, L., Su, L., Chen, Q., Xie, J., Wu, G., Yan, Y., Liang, B., Tan, J., Tang, N."Ruxolitinib for myelofibrosis". Experimental and Therapeutic Medicine 5, no. 3 (2013): 927-931. https://doi.org/10.3892/etm.2013.886
Copy and paste a formatted citation
x
Spandidos Publications style
Gu L, Su L, Chen Q, Xie J, Wu G, Yan Y, Liang B, Tan J and Tang N: Ruxolitinib for myelofibrosis. Exp Ther Med 5: 927-931, 2013.
APA
Gu, L., Su, L., Chen, Q., Xie, J., Wu, G., Yan, Y. ... Tang, N. (2013). Ruxolitinib for myelofibrosis. Experimental and Therapeutic Medicine, 5, 927-931. https://doi.org/10.3892/etm.2013.886
MLA
Gu, L., Su, L., Chen, Q., Xie, J., Wu, G., Yan, Y., Liang, B., Tan, J., Tang, N."Ruxolitinib for myelofibrosis". Experimental and Therapeutic Medicine 5.3 (2013): 927-931.
Chicago
Gu, L., Su, L., Chen, Q., Xie, J., Wu, G., Yan, Y., Liang, B., Tan, J., Tang, N."Ruxolitinib for myelofibrosis". Experimental and Therapeutic Medicine 5, no. 3 (2013): 927-931. https://doi.org/10.3892/etm.2013.886
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