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Article

Propyl gallate inhibits TPA‑induced inflammation via the nuclear factor‑κB pathway in human THP‑1 monocytes

  • Authors:
    • Hung‑Chih Hsu
    • Wan‑Chen Lin
    • Pey‑Jium Chang
    • Chang‑Zern Hong
    • Ching‑Hsein Chen
  • View Affiliations / Copyright

    Affiliations: Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Chiayi, Taiwan, R.O.C., Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan, R.O.C. , Department of Physical Therapy, Hung Kuang University, Taichung, Taiwan, R.O.C., Department of Microbiology, Immunology and Biopharmaceuticals, College of Life Sciences, National Chiayi University, Chiayi, Taiwan, R.O.C.
  • Pages: 964-968
    |
    Published online on: January 16, 2013
       https://doi.org/10.3892/etm.2013.896
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Abstract

Propyl gallate (PG) is an antioxidant that has been used as an additive in several foods to protect against oxidation. The present study examined the anti‑inflammatory effect of PG on 12‑O‑tetradecanoylphorbol‑13‑acetate (TPA)‑induced inflammation in human THP‑1 monocytes. Pretreatment with PG markedly inhibited the TPA‑induced expression levels of cyclooxygenase‑2 and prostaglandin E2. The application of PG significantly inhibited the nuclear translocation of p65, a subunit of nuclear factor‑κB (NF‑κB) and phosphorylation of p65 (Ser536) in TPA‑treated THP‑1 cells. PG also inhibited the phosphorylation of IκB and IκB kinase. These results indicate that PG inhibits the inflammatory response by blocking the NF‑κB signaling pathway in TPA‑induced THP‑1 monocytes. Therefore, PG may be useful as a therapeutic agent in inflammatory diseases.
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Copy and paste a formatted citation
Spandidos Publications style
Hsu HC, Lin WC, Chang PJ, Hong CZ and Chen CH: Propyl gallate inhibits TPA‑induced inflammation via the nuclear factor‑κB pathway in human THP‑1 monocytes. Exp Ther Med 5: 964-968, 2013.
APA
Hsu, H., Lin, W., Chang, P., Hong, C., & Chen, C. (2013). Propyl gallate inhibits TPA‑induced inflammation via the nuclear factor‑κB pathway in human THP‑1 monocytes. Experimental and Therapeutic Medicine, 5, 964-968. https://doi.org/10.3892/etm.2013.896
MLA
Hsu, H., Lin, W., Chang, P., Hong, C., Chen, C."Propyl gallate inhibits TPA‑induced inflammation via the nuclear factor‑κB pathway in human THP‑1 monocytes". Experimental and Therapeutic Medicine 5.3 (2013): 964-968.
Chicago
Hsu, H., Lin, W., Chang, P., Hong, C., Chen, C."Propyl gallate inhibits TPA‑induced inflammation via the nuclear factor‑κB pathway in human THP‑1 monocytes". Experimental and Therapeutic Medicine 5, no. 3 (2013): 964-968. https://doi.org/10.3892/etm.2013.896
Copy and paste a formatted citation
x
Spandidos Publications style
Hsu HC, Lin WC, Chang PJ, Hong CZ and Chen CH: Propyl gallate inhibits TPA‑induced inflammation via the nuclear factor‑κB pathway in human THP‑1 monocytes. Exp Ther Med 5: 964-968, 2013.
APA
Hsu, H., Lin, W., Chang, P., Hong, C., & Chen, C. (2013). Propyl gallate inhibits TPA‑induced inflammation via the nuclear factor‑κB pathway in human THP‑1 monocytes. Experimental and Therapeutic Medicine, 5, 964-968. https://doi.org/10.3892/etm.2013.896
MLA
Hsu, H., Lin, W., Chang, P., Hong, C., Chen, C."Propyl gallate inhibits TPA‑induced inflammation via the nuclear factor‑κB pathway in human THP‑1 monocytes". Experimental and Therapeutic Medicine 5.3 (2013): 964-968.
Chicago
Hsu, H., Lin, W., Chang, P., Hong, C., Chen, C."Propyl gallate inhibits TPA‑induced inflammation via the nuclear factor‑κB pathway in human THP‑1 monocytes". Experimental and Therapeutic Medicine 5, no. 3 (2013): 964-968. https://doi.org/10.3892/etm.2013.896
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