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Article

Octreotide and celecoxib synergistically encapsulate VX2 hepatic allografts following transcatheter arterial embolisation

  • Authors:
    • Huan Tong
    • Xiao Li
    • Chun-Le Zhang
    • Jin-Hang Gao
    • Shi-Lei Wen
    • Zhi-Yin Huang
    • Cheng-Wei Tang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, P.R. China, Division of Peptides Related with Human Diseases, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, P.R. China
  • Pages: 777-782
    |
    Published online on: January 16, 2013
       https://doi.org/10.3892/etm.2013.897
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Abstract

To evaluate the encapsulation of VX2 hepatic allografts in rabbits induced by octreotide and celecoxib administration following transcatheter arterial embolisation (TAE), rabbits with hepatic VX2 allografts were divided into four groups: control, TAE, octreotide + celecoxib (O+C) and the multimodality therapy (TAE+O+C). Allograft metastasis, capsule thickness and percentage of clear cells were measured and vascular endothelial growth factor (VEGF) and CD31 were detected by immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR) analysis. The extrahepatic metastases of each intervention group were significantly fewer than those of the control group, with the TAE+O+C group exhibiting the fewest extrahepatic metastases. The TAE+O+C group had the greatest proportion of clear cells and thickest capsule on day 30. Increased capsule thickness was negatively correlated with tumour metastasis. In addition, VEGF expression levels assessed by immunohistochemistry and RT-PCR in the three intervention groups were significantly lower than those in the control group. Furthermore, the TAE+O+C group had a significantly reduced CD31 count induced by TAE. These results demonstrate that TAE, followed by long-term administration of octreotide and celecoxib, synergistically inhibits VX2 hepatic allograft metastasis by increasing the proportion of clear cells, promoting encapsulation and inhibiting angiogenesis.
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Copy and paste a formatted citation
Spandidos Publications style
Tong H, Li X, Zhang C, Gao J, Wen S, Huang Z and Tang C: Octreotide and celecoxib synergistically encapsulate VX2 hepatic allografts following transcatheter arterial embolisation. Exp Ther Med 5: 777-782, 2013.
APA
Tong, H., Li, X., Zhang, C., Gao, J., Wen, S., Huang, Z., & Tang, C. (2013). Octreotide and celecoxib synergistically encapsulate VX2 hepatic allografts following transcatheter arterial embolisation. Experimental and Therapeutic Medicine, 5, 777-782. https://doi.org/10.3892/etm.2013.897
MLA
Tong, H., Li, X., Zhang, C., Gao, J., Wen, S., Huang, Z., Tang, C."Octreotide and celecoxib synergistically encapsulate VX2 hepatic allografts following transcatheter arterial embolisation". Experimental and Therapeutic Medicine 5.3 (2013): 777-782.
Chicago
Tong, H., Li, X., Zhang, C., Gao, J., Wen, S., Huang, Z., Tang, C."Octreotide and celecoxib synergistically encapsulate VX2 hepatic allografts following transcatheter arterial embolisation". Experimental and Therapeutic Medicine 5, no. 3 (2013): 777-782. https://doi.org/10.3892/etm.2013.897
Copy and paste a formatted citation
x
Spandidos Publications style
Tong H, Li X, Zhang C, Gao J, Wen S, Huang Z and Tang C: Octreotide and celecoxib synergistically encapsulate VX2 hepatic allografts following transcatheter arterial embolisation. Exp Ther Med 5: 777-782, 2013.
APA
Tong, H., Li, X., Zhang, C., Gao, J., Wen, S., Huang, Z., & Tang, C. (2013). Octreotide and celecoxib synergistically encapsulate VX2 hepatic allografts following transcatheter arterial embolisation. Experimental and Therapeutic Medicine, 5, 777-782. https://doi.org/10.3892/etm.2013.897
MLA
Tong, H., Li, X., Zhang, C., Gao, J., Wen, S., Huang, Z., Tang, C."Octreotide and celecoxib synergistically encapsulate VX2 hepatic allografts following transcatheter arterial embolisation". Experimental and Therapeutic Medicine 5.3 (2013): 777-782.
Chicago
Tong, H., Li, X., Zhang, C., Gao, J., Wen, S., Huang, Z., Tang, C."Octreotide and celecoxib synergistically encapsulate VX2 hepatic allografts following transcatheter arterial embolisation". Experimental and Therapeutic Medicine 5, no. 3 (2013): 777-782. https://doi.org/10.3892/etm.2013.897
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