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Article

Effects of different doses of sufentanil and remifentanil combined with propofol in target-controlled infusion on stress reaction in elderly patients

  • Authors:
    • Li-Guo Hu
    • Jian-Hui Pan
    • Juan Li
    • Fang Kang
    • Ling Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, P.R. China, Department of Pharmacy, The Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, P.R. China
  • Pages: 807-812
    |
    Published online on: January 17, 2013
       https://doi.org/10.3892/etm.2013.900
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Abstract

The current study aimed to observe the effects of sufentanil and remifentanil combined with propofol in target‑controlled infusion (TCI) on perioperative stress reaction in elderly patients. A total of 80 elderly patients requiring general anesthesia were recruited. They were divided into four groups (each n=20) according to different target concentrations of remifentanil and sufentanil. These target concentrations were: 4 ng/ml remifentanil + 0.2 ng/ml sufentanil for group I; 3 ng/ml remifentanil + 0.3 ng/ml sufentanil for group II; 2 ng/ml remifentanil + 0.5 ng/ml sufentanil for anesthesia induction and post-intubation 3 ng/ml remifentanil + 0.2 ng/ml sufentanil for anesthesia maintenance for group III; and 5 ng/ml remifentanil for anesthesia induction and post-intubation 4 ng/ml remifentanil for anesthesia maintenance for group IV. Norepinephrine (NE), epinephrine (E) and angiotensin II (Ang II) levels in plasma were measured prior to the induction of anesthesia, as well as at several different time-points following surgery. The numbers of intraoperative severe hemodynamic fluctuation, postoperative eye-opening and extubation time, and post-extubation restlessness and pain scores were recorded. Group IV had a larger circulation fluctuation control number and higher levels of NE, E and Ang II at 3 h after surgery than any other group (P<0.01). Although group IV had shorter postoperative eye-opening and extubation times compared with the other groups (P<0.05), it also had higher restlessness and pain scores (P<0.01). The combined use of sufentanil and remifentanil stabilizes perioperative hemodynamics and reduces stress hormone levels.
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Copy and paste a formatted citation
Spandidos Publications style
Hu L, Pan J, Li J, Kang F and Jiang L: Effects of different doses of sufentanil and remifentanil combined with propofol in target-controlled infusion on stress reaction in elderly patients. Exp Ther Med 5: 807-812, 2013.
APA
Hu, L., Pan, J., Li, J., Kang, F., & Jiang, L. (2013). Effects of different doses of sufentanil and remifentanil combined with propofol in target-controlled infusion on stress reaction in elderly patients. Experimental and Therapeutic Medicine, 5, 807-812. https://doi.org/10.3892/etm.2013.900
MLA
Hu, L., Pan, J., Li, J., Kang, F., Jiang, L."Effects of different doses of sufentanil and remifentanil combined with propofol in target-controlled infusion on stress reaction in elderly patients". Experimental and Therapeutic Medicine 5.3 (2013): 807-812.
Chicago
Hu, L., Pan, J., Li, J., Kang, F., Jiang, L."Effects of different doses of sufentanil and remifentanil combined with propofol in target-controlled infusion on stress reaction in elderly patients". Experimental and Therapeutic Medicine 5, no. 3 (2013): 807-812. https://doi.org/10.3892/etm.2013.900
Copy and paste a formatted citation
x
Spandidos Publications style
Hu L, Pan J, Li J, Kang F and Jiang L: Effects of different doses of sufentanil and remifentanil combined with propofol in target-controlled infusion on stress reaction in elderly patients. Exp Ther Med 5: 807-812, 2013.
APA
Hu, L., Pan, J., Li, J., Kang, F., & Jiang, L. (2013). Effects of different doses of sufentanil and remifentanil combined with propofol in target-controlled infusion on stress reaction in elderly patients. Experimental and Therapeutic Medicine, 5, 807-812. https://doi.org/10.3892/etm.2013.900
MLA
Hu, L., Pan, J., Li, J., Kang, F., Jiang, L."Effects of different doses of sufentanil and remifentanil combined with propofol in target-controlled infusion on stress reaction in elderly patients". Experimental and Therapeutic Medicine 5.3 (2013): 807-812.
Chicago
Hu, L., Pan, J., Li, J., Kang, F., Jiang, L."Effects of different doses of sufentanil and remifentanil combined with propofol in target-controlled infusion on stress reaction in elderly patients". Experimental and Therapeutic Medicine 5, no. 3 (2013): 807-812. https://doi.org/10.3892/etm.2013.900
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