Prothrombotic state in senile patients with acute exacerbations of chronic obstructive pulmonary disease combined with respiratory failure

  • Authors:
    • Ya‑Jun Song
    • Zhe‑Hui Zhou
    • Yao‑Kang Liu
    • Shi‑Ming Rao
    • Ying‑Jun Huang
  • View Affiliations

  • Published online on: January 22, 2013     https://doi.org/10.3892/etm.2013.919
  • Pages: 1184-1188
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aim of this study was to study the clinical value of prethrombotic state and treatment with low molecular weight heparin (LMWH) in senile patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) combined with respiratory failure. Hemorheological markers (hematocrit, blood viscosity and plasma viscosity), fibrinogen (FIB), D‑dimer and gas analysis were evaluated in 30 senile patients with AECOPD combined with respiratory failure and compared with those in 30 cases without respiratory failure. A total of 30 cases with AECOPD combined with respiratory failure were randomly divided into treatment and control groups. The two groups received conventional treatment. The treatment group also received LMWH injections every 12 h for 6 days and the clinical effect was observed. The levels of FIB, D‑dimer, hematocrit, blood viscosity and plasma viscosity were significantly higher in the patients with AECOPD combined with respiratory failure compared with those in the patients without respiratory failure. The plasma D‑dimer and FIB levels had significantly positive correlations with the partial pressure of CO2 (PaCO2) and negative correlations with the partial pressure of O2 (PaO2) in the patients with AECOPD combined with respiratory failure. The curative effect was improved in the treatment group, compared with that in the control group without side‑effects. However, no significant changes in activated partial thromboplastin time (APTT) and international normalized ratio (INR) were observed between the treatment and control groups. The senile patients with AECOPD combined with respiratory failure suffered from hypercoagulation. Early detection and diagnosis of the prethrombotic state and timely treatment with LMWH may benefit these patients without side‑effects.
View References

Related Articles

Journal Cover

April 2013
Volume 5 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Song YJ, Zhou ZH, Liu YK, Rao SM and Huang YJ: Prothrombotic state in senile patients with acute exacerbations of chronic obstructive pulmonary disease combined with respiratory failure. Exp Ther Med 5: 1184-1188, 2013.
APA
Song, Y., Zhou, Z., Liu, Y., Rao, S., & Huang, Y. (2013). Prothrombotic state in senile patients with acute exacerbations of chronic obstructive pulmonary disease combined with respiratory failure. Experimental and Therapeutic Medicine, 5, 1184-1188. https://doi.org/10.3892/etm.2013.919
MLA
Song, Y., Zhou, Z., Liu, Y., Rao, S., Huang, Y."Prothrombotic state in senile patients with acute exacerbations of chronic obstructive pulmonary disease combined with respiratory failure". Experimental and Therapeutic Medicine 5.4 (2013): 1184-1188.
Chicago
Song, Y., Zhou, Z., Liu, Y., Rao, S., Huang, Y."Prothrombotic state in senile patients with acute exacerbations of chronic obstructive pulmonary disease combined with respiratory failure". Experimental and Therapeutic Medicine 5, no. 4 (2013): 1184-1188. https://doi.org/10.3892/etm.2013.919