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Article

Gender and age affect the levels of exhaled nitric oxide in healthy children

  • Authors:
    • Han Zhang
    • Linhua Shu
    • Xuxu Cai
    • Zhijia Wang
    • Xuyong Jiao
    • Fen Liu
    • Ping Hou
    • Li Wang
    • Lishen Shan
    • Ning Chen
    • Yunxiao Shang
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China
  • Pages: 1174-1178
    |
    Published online on: January 23, 2013
       https://doi.org/10.3892/etm.2013.922
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Abstract

Asthma is a chronic inflammatory disorder of the lung and diagnosis is difficult in children. The measurement of fractional exhaled nitric oxide (FeNO) may be useful in the diagnosis and monitoring of treatments. A number of factors affect FeNO levels and their influence varies across countries and regions. This study included 300 healthy students, aged from 6 to 14 years, who participated voluntarily. A comprehensive medical survey was used and measurements of FeNO levels and spirometric parameters were recorded in Shenyang, China. We observed that the median FeNO was 11 ppb (range, 8-16 ppb) in children from the northern areas of China. For males, the median level was 13 ppb (range, 9-18 ppb) and the median level was 10 ppb (range, 8-14 ppb) for females. There was a significant difference between males and females (P=0.007) and age was correlated with FeNO (R2=0.6554), while weight, height, body mass index (BMI), forced vital capacity (FVC), forced expiratory volume (FEV1), FEV1/FVC and peak expiratory flow (PEF) had no correlation with FeNO. In conclusion, the median FeNO is 11 ppb (range, 8-16 ppb) in male and female healthy children from northern areas of China and is affected by gender and age.
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1 

Perzanowski MS, Divjan A, Mellins RB, et al: Exhaled NO among inner-city children in New York City. J Asthma. 47:1015–1021. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Buchvald F, Baraldi E, Carraro S, et al: Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years. J Allergy Clin Immunol. 115:1130–1136. 2005.PubMed/NCBI

3 

Wong GW, Liu EK, Leung TF, et al: High levels and gender difference of exhaled nitric oxide in Chinese schoolchildren. Clin Exp Allergy. 35:889–893. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Yao TC, Lee WI, Ou LS, Chen LC, Yeh KW and Huang JL; PATCH Study Group: Reference values of exhaled nitric oxide in healthy Asian children aged 5 to 18 years. Eur Respir J. 39:378–384. 2012.PubMed/NCBI

5 

Asher MI and Weiland SK: The International Study of Asthma and Allergies in Childhood (ISAAC). ISAAC Steering Committee. Clin Exp Allergy. 28(Suppl 5): 52–66; discussion 90–1, 1998.

6 

Ishizuka T, Matsuzaki S, Aoki H, et al: Prevalence of asthma symptoms based on the European Community Respiratory Health Survey questionnaire and FENO in university students: gender differences in symptoms and FENO. Allergy Asthma Clin Immunol. 7:152011. View Article : Google Scholar

7 

Xu F, Zou Z, Yan S, et al: Fractional exhaled nitric oxide in relation to asthma, allergic rhinitis, and atopic dermatitis in Chinese children. J Asthma. 48:1001–1006. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Global Strategy for Asthma Management and Prevention: 2011.Global Initiative for Asthma. https://www.ginasthma.org. Accessed December 1, 2011.

9 

American Thoracic Society and European Respiratory Society: ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med. 171:912–930. 2005. View Article : Google Scholar : PubMed/NCBI

10 

No authors listed:. Recommendations for standardized procedures for the on-line and off-line measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide in adults and children-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. Am J Respir Crit Care Med. 160:2104–2117. 1999.

11 

Baraldi E and de Jongste JC; European Respiratory Society/ American Thoracic Society (ERS/ATS) Task Force: Measurement of exhaled nitric oxide in children. 2001. Eur Respir J. 20:223–237. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Miller MR, Hankinson J, Brusasco V, et al: Standardisation of spirometry. Eur Respir J. 26:319–338. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Barnes PJ, Dweik RA, Gelb AF, et al: Exhaled nitric oxide in pulmonary diseases: a comprehensive review. Chest. 138:682–692. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Ricciardolo FL, Sterk PJ, Gaston B and Folkerts G: Nitric oxide in health and disease of the respiratory system. Physiol Rev. 84:731–765. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Motomura C, Odajima H, Tezuka J, et al: Effect of age on relationship between exhaled nitric oxide and airway hyper-responsiveness in asthmatic children. Chest. 136:519–525. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Fukuhara A, Saito J, Sato S, et al: Validation study of asthma screening criteria based on subjective symptoms and fractional exhaled nitric oxide. Ann Allergy Asthma Immunol. 107:480–486. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Cordeiro D, Rudolphus A, Snoey E and Braunstahl GJ: Utility of nitric oxide for the diagnosis of asthma in an allergy clinic population. Allergy Asthma Proc. 32:119–126. 2011. View Article : Google Scholar : PubMed/NCBI

18 

de Jongste JC, Carraro S, Hop WC; CHARISM Study Group; Baraldi E: Daily telemonitoring of exhaled nitric oxide and symptoms in the treatment of childhood asthma. Am J Respir Crit Care Med. 179:93–97. 2009.PubMed/NCBI

19 

Verini M, Consilvio NP, Di Pillo S, et al: FeNO as a marker of airways inflammation: the possible implications in childhood asthma management. J Allergy (Cairo) 2010. pii:691425:2010.PubMed/NCBI

20 

Ferrer M, Jarque A, Tosca R and Michavila A: Is it necessary to treat all asthmatic children with raised levels of exhaled nitric oxide?: treating the patient or the data. Allergol Immunopathol (Madr). 39:280–283. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Dweik RA, Boggs PB, Erzurum SC, et al: An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med. 184:602–615. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Dor-Wojnarowska A, Liebhart J, Grabowski M, Czapla L, Grabowski K and Panaszek B: Exhaled nitric oxide in patients with esophagitis. Pneumonol Alergol Pol. 79:272–277. 2011.(In Polish).

23 

Kovesi T, Kulka R and Dales R: Exhaled nitric oxide concentration is affected by age, height, and race in healthy 9- to 12-year-old children. Chest. 133:169–175. 2008.PubMed/NCBI

24 

Linn WS, Rappaport EB, Berhane KT, Bastain TM, Avol EL and Gilliland FD: Exhaled nitric oxide in a population-based study of southern California schoolchildren. Respir Res. 10:282009. View Article : Google Scholar : PubMed/NCBI

25 

Mahut B, Peiffer C, Thibaudon M, et al: What does a single exhaled nitric oxide measurement tell us in asthmatic children? J Asthma. 46:810–814. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Laoudi Y, Nikasinovic L, Sahraoui F, Grimfeld A, Momas I and Just J: Passive smoking is a major determinant of exhaled nitric oxide levels in allergic asthmatic children. Allergy. 65:491–497. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Matsunaga K, Hirano T, Kawayama T, et al: Reference ranges for exhaled nitric oxide fraction in healthy Japanese adult population. Allergol Int. 59:363–367. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Papakosta D, Latsios D, Manika K, Porpodis K, Kontakioti E and Gioulekas D: Asthma control test is correlated to FEV1 and nitric oxide in Greek asthmatic patients: influence of treatment. J Asthma. 48:901–906. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang H, Shu L, Cai X, Wang Z, Jiao X, Liu F, Hou P, Wang L, Shan L, Chen N, Chen N, et al: Gender and age affect the levels of exhaled nitric oxide in healthy children. Exp Ther Med 5: 1174-1178, 2013.
APA
Zhang, H., Shu, L., Cai, X., Wang, Z., Jiao, X., Liu, F. ... Shang, Y. (2013). Gender and age affect the levels of exhaled nitric oxide in healthy children. Experimental and Therapeutic Medicine, 5, 1174-1178. https://doi.org/10.3892/etm.2013.922
MLA
Zhang, H., Shu, L., Cai, X., Wang, Z., Jiao, X., Liu, F., Hou, P., Wang, L., Shan, L., Chen, N., Shang, Y."Gender and age affect the levels of exhaled nitric oxide in healthy children". Experimental and Therapeutic Medicine 5.4 (2013): 1174-1178.
Chicago
Zhang, H., Shu, L., Cai, X., Wang, Z., Jiao, X., Liu, F., Hou, P., Wang, L., Shan, L., Chen, N., Shang, Y."Gender and age affect the levels of exhaled nitric oxide in healthy children". Experimental and Therapeutic Medicine 5, no. 4 (2013): 1174-1178. https://doi.org/10.3892/etm.2013.922
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang H, Shu L, Cai X, Wang Z, Jiao X, Liu F, Hou P, Wang L, Shan L, Chen N, Chen N, et al: Gender and age affect the levels of exhaled nitric oxide in healthy children. Exp Ther Med 5: 1174-1178, 2013.
APA
Zhang, H., Shu, L., Cai, X., Wang, Z., Jiao, X., Liu, F. ... Shang, Y. (2013). Gender and age affect the levels of exhaled nitric oxide in healthy children. Experimental and Therapeutic Medicine, 5, 1174-1178. https://doi.org/10.3892/etm.2013.922
MLA
Zhang, H., Shu, L., Cai, X., Wang, Z., Jiao, X., Liu, F., Hou, P., Wang, L., Shan, L., Chen, N., Shang, Y."Gender and age affect the levels of exhaled nitric oxide in healthy children". Experimental and Therapeutic Medicine 5.4 (2013): 1174-1178.
Chicago
Zhang, H., Shu, L., Cai, X., Wang, Z., Jiao, X., Liu, F., Hou, P., Wang, L., Shan, L., Chen, N., Shang, Y."Gender and age affect the levels of exhaled nitric oxide in healthy children". Experimental and Therapeutic Medicine 5, no. 4 (2013): 1174-1178. https://doi.org/10.3892/etm.2013.922
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