Gender and age affect the levels of exhaled nitric oxide in healthy children

Zhang,Han; Shu,Linhua; Cai,Xuxu; Wang,Zhijia; Jiao,Xuyong; Liu,Fen; Hou,Ping; Wang,Li; Shan,Lishen; Chen,Ning; Shang,Yunxiao

doi:10.3892/etm.2013.922

Gender and age affect the levels of exhaled nitric oxide in healthy children

Authors:
- Han Zhang
- Linhua Shu
- Xuxu Cai
- Zhijia Wang
- Xuyong Jiao
- Fen Liu
- Ping Hou
- Li Wang
- Lishen Shan
- Ning Chen
- Yunxiao Shang
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Affiliations: Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China
Published online on: January 23, 2013 https://doi.org/10.3892/etm.2013.922
Pages: 1174-1178

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Abstract

Asthma is a chronic inflammatory disorder of the lung and diagnosis is difficult in children. The measurement of fractional exhaled nitric oxide (FeNO) may be useful in the diagnosis and monitoring of treatments. A number of factors affect FeNO levels and their influence varies across countries and regions. This study included 300 healthy students, aged from 6 to 14 years, who participated voluntarily. A comprehensive medical survey was used and measurements of FeNO levels and spirometric parameters were recorded in Shenyang, China. We observed that the median FeNO was 11 ppb (range, 8-16 ppb) in children from the northern areas of China. For males, the median level was 13 ppb (range, 9-18 ppb) and the median level was 10 ppb (range, 8-14 ppb) for females. There was a significant difference between males and females (P=0.007) and age was correlated with FeNO (R2=0.6554), while weight, height, body mass index (BMI), forced vital capacity (FVC), forced expiratory volume (FEV1), FEV1/FVC and peak expiratory flow (PEF) had no correlation with FeNO. In conclusion, the median FeNO is 11 ppb (range, 8-16 ppb) in male and female healthy children from northern areas of China and is affected by gender and age.

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