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Article

Induction chemotherapy with cetuximab, carboplatin and paclitaxel for the treatment of locally advanced squamous cell carcinoma of the head and neck

  • Authors:
    • Jessica Bauman
    • Corey Langer
    • Harry Quon
    • Kenneth Algazy
    • Alexander Lin
    • Arati Desai
    • Faith Mutale
    • Jared Weiss
  • View Affiliations / Copyright

    Affiliations: Division of Hematology and Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA, Division of Hematology and Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA, Department of Radiation Oncology, Johns Hopkins University, Baltimore, MD 21205, USA, Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA, Division of Hematology and Oncology, University of North Carolina, Chapel Hill, NC 27599, USA
  • Pages: 1247-1253
    |
    Published online on: February 5, 2013
       https://doi.org/10.3892/etm.2013.948
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Abstract

Although controversy exists in the management of locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN), clinicians often use induction chemotherapy for treatment of the most advanced cases. One promising regimen combines weekly cetuximab (400 mg/m2 loading dose followed by 250 mg/m2) with carboplatin (AUC of 2) and paclitaxel (90 mg/m2). We retrospectively evaluated patients treated with this regimen prior to definitive chemoradiation or surgery between May 2008 and December 2011. The primary endpoint used for this retrospective analysis was feasibility. Thirty consecutive, unselected patients were included. Median follow-up was 13.7 months (range, 5.0-38.7 months). All but one patient had stage IV SCCHN. Dose intensity was high for carboplatin (92%), paclitaxel (93%) and cetuximab (85%). Grade 3-4 toxicities occurred in <7% of the study population and were limited to rash, neutropenia and infusion reactions. Response rate (RR) to induction chemotherapy was 97% (30% complete response, 67% partial response). All patients completed subsequent chemoradiotherapy or surgery. Nineteen patients (63%) demonstrated a complete response and 11 patients (37%) demonstrated a partial response. Median overall survival and progression-free survival data are not yet mature. The RR to therapy in our off-protocol experience is at least comparable to that observed in the two phase II studies of this regimen and appears superior to that observed with docetaxel, cisplatin and fluorouracil (TPF).
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1 

Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin. 60:277–300. 2010. View Article : Google Scholar

2 

Chandana SR and Conley BA: Neoadjuvant chemotherapy for locally advanced squamous cancers of the head and neck: current status and future prospects. Curr Opin Oncol. 21:218–223. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Cohen EE, Lingen MW and Vokes EE: The expanding role of systemic therapy in head and neck cancer. J Clin Oncol. 22:1743–1752. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Pfister DG, Ang KK, Brizel D, et al: NCCN Practice Guidelines in Oncology, Head and Neck Cancers, Version 2.2011. National Comprehensive Cancer Network®; 2011

5 

Brockstein B, Haraf DJ, Rademaker AW, et al: Patterns of failure, prognostic factors and survival in locoregionally advanced head and neck cancer treated with concomitant chemoradiotherapy: a 9-year, 337-patient, multi-institutional experience. Ann Oncol. 15:1179–1186. 2004.

6 

Posner MR, Hershock DM, Blajman CR, et al TAX 324 Study Group: Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer. N Engl J Med. 357:1705–1715. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Vermorken JB, Remenar E, van Herpen C, et al EORTC 24971/TAX 323 Study Group: Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer. N Engl J Med. 357:1695–1704. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Beitler JJ and Cooper JS: Seduction by induction? J Clin Oncol. 27:9–10. 2009. View Article : Google Scholar

9 

Haddad RI and Posner MR: Induction chemotherapy in head and neck cancer. J Clin Oncol. 27:e52–e53. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Cohen EW, Karrison T, Kocherginsky M, Huang C, Agulnik M, Mittal B, Yunus F, Samant S, Brockstein B, Raez L, Mehra R, Kumar P, Ondrey F, Seiwert T, Villaflor V, Haraf D and Vokes E: DeCIDE: A phase III randomized trial of docetaxel (D), cisplatin (P), 5-fluorouracil (F) (TPF) induction chemotherapy (IC) in patients with N2/N3 locally advanced squamous cell carcinoma of the head and neck (SCCHN). J Clin Oncol. 30(Suppl): abstr 5500. 2012.PubMed/NCBI

11 

Haddad RI, Rabinowits G, Tishler RB, Adkins D, Khuri FR, Clark J, Lorch JH, Limaye SA, Wirth LJ, O’Neill A, Riley S and Posner MR: The PARADIGM trial: A phase III study comparing sequential therapy (ST) to concurrent chemoradiotherapy (CRT) in locally advanced head and neck cancer (LANHC). J Clin Oncol. 30(Suppl): abstr 5501. 2012.

12 

Haraf DJ, Rosen FR, Stenson K, et al: Induction chemotherapy followed by concomitant TFHX chemoradiotherapy with reduced dose radiation in advanced head and neck cancer. Clin Cancer Res. 9:5936–5943. 2003.PubMed/NCBI

13 

Bonner JA, Harari PM, Giralt J, et al: Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 354:567–578. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Bonner JA, Harari PM, Giralt J, et al: Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol. 11:21–28. 2010.PubMed/NCBI

15 

Vermorken JB, Mesia R, Rivera F, et al: Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med. 359:1116–1127. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Kies MS, Holsinger FC, Lee JJ, et al: Induction chemotherapy and cetuximab for locally advanced squamous cell carcinoma of the head and neck: results from a phase II prospective trial. J Clin Oncol. 28:8–14. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Wanebo HJ and Ghebremichael M, Burtness B, Spencer S, Ridge J, Forastiere A and Ghebremichael M: Phase II evaluation of cetuximab (C225) combined with induction paclitaxel and carboplatin followed by C225, paclitaxel, carboplatin, and radiation for stage III/IV operable squamous cancer of the head and neck (ECOG, E2303). J Clin Oncol (ASCO Annual Meeting Proceedings Part I) (Suppl). (18S): 60152007.

18 

Seiwert TY, Haraf DJ, Cohen EE, et al: A randomized phase II trial of cetuximab-based induction chemotherapy followed by concurrent cetuximab, 5-FU, hydroxyurea, and hyperfractionated radiation (CetuxFHX), or cetuximab, cisplatin, and accelerated radiation with concomitant boost (CetuxPX) in patients with locoregionally advanced head and neck cancer (HNC). J Clin Oncol. 29:2011.(suppl; abstr 5519).

19 

Forastiere AA, Goepfert H, Maor M, et al: Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med. 349:2091–2098. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Adelstein DJ, Moon J, Hanna E, et al: Docetaxel, cisplatin, and fluorouracil induction chemotherapy followed by accelerated fractionation/concomitant boost radiation and concurrent cisplatin in patients with advanced squamous cell head and neck cancer: A Southwest Oncology Group phase II trial (S0216). Head Neck. 32:221–228. 2010.

21 

Ang KK, Harris J, Wheeler R, et al: Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 363:24–35. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Fakhry C, Westra WH, Li S, et al: Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst. 100:261–269. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Lassen P, Eriksen JG, Hamilton-Dutoit S, Tramm T, Alsner J and Overgaard J: Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck. J Clin Oncol. 27:1992–1998. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Weiss J: Induction Chemotherapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck. http://clinicaltrials.gov/ct2/show/NCT01412229?term=jared+weiss&rank=2uri. Accessed December 7, 2012.

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Copy and paste a formatted citation
Spandidos Publications style
Bauman J, Langer C, Quon H, Algazy K, Lin A, Desai A, Mutale F and Weiss J: Induction chemotherapy with cetuximab, carboplatin and paclitaxel for the treatment of locally advanced squamous cell carcinoma of the head and neck. Exp Ther Med 5: 1247-1253, 2013.
APA
Bauman, J., Langer, C., Quon, H., Algazy, K., Lin, A., Desai, A. ... Weiss, J. (2013). Induction chemotherapy with cetuximab, carboplatin and paclitaxel for the treatment of locally advanced squamous cell carcinoma of the head and neck. Experimental and Therapeutic Medicine, 5, 1247-1253. https://doi.org/10.3892/etm.2013.948
MLA
Bauman, J., Langer, C., Quon, H., Algazy, K., Lin, A., Desai, A., Mutale, F., Weiss, J."Induction chemotherapy with cetuximab, carboplatin and paclitaxel for the treatment of locally advanced squamous cell carcinoma of the head and neck". Experimental and Therapeutic Medicine 5.4 (2013): 1247-1253.
Chicago
Bauman, J., Langer, C., Quon, H., Algazy, K., Lin, A., Desai, A., Mutale, F., Weiss, J."Induction chemotherapy with cetuximab, carboplatin and paclitaxel for the treatment of locally advanced squamous cell carcinoma of the head and neck". Experimental and Therapeutic Medicine 5, no. 4 (2013): 1247-1253. https://doi.org/10.3892/etm.2013.948
Copy and paste a formatted citation
x
Spandidos Publications style
Bauman J, Langer C, Quon H, Algazy K, Lin A, Desai A, Mutale F and Weiss J: Induction chemotherapy with cetuximab, carboplatin and paclitaxel for the treatment of locally advanced squamous cell carcinoma of the head and neck. Exp Ther Med 5: 1247-1253, 2013.
APA
Bauman, J., Langer, C., Quon, H., Algazy, K., Lin, A., Desai, A. ... Weiss, J. (2013). Induction chemotherapy with cetuximab, carboplatin and paclitaxel for the treatment of locally advanced squamous cell carcinoma of the head and neck. Experimental and Therapeutic Medicine, 5, 1247-1253. https://doi.org/10.3892/etm.2013.948
MLA
Bauman, J., Langer, C., Quon, H., Algazy, K., Lin, A., Desai, A., Mutale, F., Weiss, J."Induction chemotherapy with cetuximab, carboplatin and paclitaxel for the treatment of locally advanced squamous cell carcinoma of the head and neck". Experimental and Therapeutic Medicine 5.4 (2013): 1247-1253.
Chicago
Bauman, J., Langer, C., Quon, H., Algazy, K., Lin, A., Desai, A., Mutale, F., Weiss, J."Induction chemotherapy with cetuximab, carboplatin and paclitaxel for the treatment of locally advanced squamous cell carcinoma of the head and neck". Experimental and Therapeutic Medicine 5, no. 4 (2013): 1247-1253. https://doi.org/10.3892/etm.2013.948
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