The correlation between post-operative fentanyl requirements and µ-opioid receptor gene A118G polymorphism in patients undergoing radical gastrectomy

Zhang,Fan; Liao,Qin; Li,Li; Wang,Sai-Ying; Hu,Rong; Tang,Yong-Zhong; Ouyang,Wen

doi:10.3892/etm.2013.955

The correlation between post-operative fentanyl requirements and µ-opioid receptor gene A118G polymorphism in patients undergoing radical gastrectomy

Authors:
- Fan Zhang
- Qin Liao
- Li Li
- Sai-Ying Wang
- Rong Hu
- Yong-Zhong Tang
- Wen Ouyang
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Affiliations: Department of Anesthesiology, The Third Xiangya Hospital of Central South University, Changsha 410013, P.R. China
Published online on: February 11, 2013 https://doi.org/10.3892/etm.2013.955
Pages: 1147-1152

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Abstract

The aim of this study was to investigate the effect of the µ-opioid receptor gene (OPRM1) A118G polymorphism on the requirement for post-operative fentanyl analgesia in patients undergoing radical gastrectomy. One hundred and twenty-eight gastric cancer patients scheduled to undergo radical gastrectomy under general anesthesia were enrolled in the study. Post-operative, patient-controlled intravenous analgesia of fentanyl was provided for satisfactory analgesia until 48 h after surgery. OPRM1 A118G was screened by DNA sequence analysis of polymerase chain reaction (PCR)-amplified DNA. Differences in fentanyl consumption and adverse effects were compared among the different genotypes at 24 and 48 h after surgery. The ranges of fentanyl dose in the 128 patients at 24 and 48 h after surgery were 5.4-17.3 µg/kg and 12.4‑29.9 µg/kg, respectively. Among these patients, there were 54 wild-type homozygotes (AA), 53 heterozygotes (AG) and 21 mutant homozygotes (GG). The frequency of the G allele was 0.371 in the OPRM1 polymorphism. There were no significant differences in fentanyl dose or adverse effects, including nausea, vomiting and dizziness, for the OPRM1 A118G polymorphism (P>0.05). The OPRM1 A118G polymorphism does not play a significant role in post-operative fentanyl analgesic dose or post-operative nausea, vomiting and dizziness in patients undergoing radical gastrectomy.

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