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Article

The correlation between post-operative fentanyl requirements and µ-opioid receptor gene A118G polymorphism in patients undergoing radical gastrectomy

  • Authors:
    • Fan Zhang
    • Qin Liao
    • Li Li
    • Sai-Ying Wang
    • Rong Hu
    • Yong-Zhong Tang
    • Wen Ouyang
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The Third Xiangya Hospital of Central South University, Changsha 410013, P.R. China
  • Pages: 1147-1152
    |
    Published online on: February 11, 2013
       https://doi.org/10.3892/etm.2013.955
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Abstract

The aim of this study was to investigate the effect of the µ-opioid receptor gene (OPRM1) A118G polymorphism on the requirement for post-operative fentanyl analgesia in patients undergoing radical gastrectomy. One hundred and twenty-eight gastric cancer patients scheduled to undergo radical gastrectomy under general anesthesia were enrolled in the study. Post-operative, patient-controlled intravenous analgesia of fentanyl was provided for satisfactory analgesia until 48 h after surgery. OPRM1 A118G was screened by DNA sequence analysis of polymerase chain reaction (PCR)-amplified DNA. Differences in fentanyl consumption and adverse effects were compared among the different genotypes at 24 and 48 h after surgery. The ranges of fentanyl dose in the 128 patients at 24 and 48 h after surgery were 5.4-17.3 µg/kg and 12.4‑29.9 µg/kg, respectively. Among these patients, there were 54 wild-type homozygotes (AA), 53 heterozygotes (AG) and 21 mutant homozygotes (GG). The frequency of the G allele was 0.371 in the OPRM1 polymorphism. There were no significant differences in fentanyl dose or adverse effects, including nausea, vomiting and dizziness, for the OPRM1 A118G polymorphism (P>0.05). The OPRM1 A118G polymorphism does not play a significant role in post-operative fentanyl analgesic dose or post-operative nausea, vomiting and dizziness in patients undergoing radical gastrectomy.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang F, Liao Q, Li L, Wang S, Hu R, Tang Y and Ouyang W: The correlation between post-operative fentanyl requirements and µ-opioid receptor gene A118G polymorphism in patients undergoing radical gastrectomy. Exp Ther Med 5: 1147-1152, 2013.
APA
Zhang, F., Liao, Q., Li, L., Wang, S., Hu, R., Tang, Y., & Ouyang, W. (2013). The correlation between post-operative fentanyl requirements and µ-opioid receptor gene A118G polymorphism in patients undergoing radical gastrectomy. Experimental and Therapeutic Medicine, 5, 1147-1152. https://doi.org/10.3892/etm.2013.955
MLA
Zhang, F., Liao, Q., Li, L., Wang, S., Hu, R., Tang, Y., Ouyang, W."The correlation between post-operative fentanyl requirements and µ-opioid receptor gene A118G polymorphism in patients undergoing radical gastrectomy". Experimental and Therapeutic Medicine 5.4 (2013): 1147-1152.
Chicago
Zhang, F., Liao, Q., Li, L., Wang, S., Hu, R., Tang, Y., Ouyang, W."The correlation between post-operative fentanyl requirements and µ-opioid receptor gene A118G polymorphism in patients undergoing radical gastrectomy". Experimental and Therapeutic Medicine 5, no. 4 (2013): 1147-1152. https://doi.org/10.3892/etm.2013.955
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang F, Liao Q, Li L, Wang S, Hu R, Tang Y and Ouyang W: The correlation between post-operative fentanyl requirements and µ-opioid receptor gene A118G polymorphism in patients undergoing radical gastrectomy. Exp Ther Med 5: 1147-1152, 2013.
APA
Zhang, F., Liao, Q., Li, L., Wang, S., Hu, R., Tang, Y., & Ouyang, W. (2013). The correlation between post-operative fentanyl requirements and µ-opioid receptor gene A118G polymorphism in patients undergoing radical gastrectomy. Experimental and Therapeutic Medicine, 5, 1147-1152. https://doi.org/10.3892/etm.2013.955
MLA
Zhang, F., Liao, Q., Li, L., Wang, S., Hu, R., Tang, Y., Ouyang, W."The correlation between post-operative fentanyl requirements and µ-opioid receptor gene A118G polymorphism in patients undergoing radical gastrectomy". Experimental and Therapeutic Medicine 5.4 (2013): 1147-1152.
Chicago
Zhang, F., Liao, Q., Li, L., Wang, S., Hu, R., Tang, Y., Ouyang, W."The correlation between post-operative fentanyl requirements and µ-opioid receptor gene A118G polymorphism in patients undergoing radical gastrectomy". Experimental and Therapeutic Medicine 5, no. 4 (2013): 1147-1152. https://doi.org/10.3892/etm.2013.955
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