Clinical study of isosorbide mononitrate treatment for angina pectoris in coronary heart disease

Tan,Zheng; Shang,Xiaoming; Li,Li; Tian,Luobing; Ma,Yi; Peng,Yan; Gao,Lingxi

doi:10.3892/etm.2013.958

April 2013 Volume 5 Issue 4

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April 2013 Volume 5 Issue 4

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Article

Clinical study of isosorbide mononitrate treatment for angina pectoris in coronary heart disease

Authors:
- Zheng Tan
- Xiaoming Shang
- Li Li
- Luobing Tian
- Yi Ma
- Yan Peng
- Lingxi Gao
View Affiliations / Copyright

Affiliations: Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China, Second Department of Cardiovasology, Tangshan Gongren Hospital, Hebei Medical University, Tangshan, Hebei 063000, P.R. China, Hebei United University, Tangshan, Hebei 063009, P.R. China
Pages: 1133-1136
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Published online on: February 18, 2013

https://doi.org/10.3892/etm.2013.958
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Abstract

The aim of this study was to observe and investigate the clinical efficacy of an intravenous drip of isosorbide mononitrate (ISMN) for the treatment of angina pectoris in coronary heart disease. A total of 102 patients with angina pectoris in coronary heart disease were divided into two groups. For the treatment group (n=51), 20 mg ISMN was added to 250 ml 0.9% normal saline and administered by intravenous drip for 14 consecutive days, twice daily. For the control group (n=51), 10 mg glyceryl trinitrate was added to 250 ml 0.9% normal saline and administered by intravenous drip for 14 consecutive days, twice daily. The clinical efficacy and adverse reactions were compared between the two groups. The disease symptoms of the two groups were improved. Compared with the control group, the clinical efficacy and electrocardiogram examination results of the treatment group were significantly improved (P<0.05). The intravenous formulation of ISMN is an effective treatment for angina pectoris in coronary heart disease and it has the advantages of fewer adverse reactions and higher safety.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clinical study of isosorbide mononitrate treatment for angina pectoris in coronary heart disease

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