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Article

A clinical study of transcranial ultrasound as an adjuvant therapy for progressive cerebral infarction

  • Authors:
    • Xiuju Gao
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang 471003, P.R. China
  • Pages: 1244-1246
    |
    Published online on: February 19, 2013
       https://doi.org/10.3892/etm.2013.965
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Abstract

The present study aimed to investigate the clinical efficacy of transcranial ultrasound as an adjuvant therapy in combination with small doses of urokinase (UK) for the treatment of progressive cerebral infarction. Sixty-one eligible patients with progressive cerebral infarction were successively and randomly assigned into one of the following groups; 30 patients to the treatment group (transcranial ultrasound + small doses of UK) and 31 patients to the control group (single small doses of UK). Based on conventional therapy, patients in the treatment group received transcranial ultrasound. The neural function deficit scale and curative effect scores of the two groups were recorded before treatment and on the 7th and 14th days after treatment. No differences in the neural function deficit scale between the two groups was observed before treatment, however, on the 7th and 14th days after treatment, a significant decrease was evident in the treatment group (P<0.01). The overall response rate was 100% in the treatment group and 74.2% in the control group, with a significant difference (P<0.01). Transcranial ultrasound is able to contribute to the thrombolytic effects of UK and prevent the progression of thrombi, subsequently aiding the recovery of neural functions.
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1 

Dreier JP: The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease. Nat Med. 17:439–447. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Miedema I, Luijckx GJ and Uyttenboogaart M: Bleeding risk with ischemic stroke therapy. JAMA. 308:1318–1319. 2012. View Article : Google Scholar

3 

Jamieson DG: Diagnosis of ischemic stroke. Am J Med. 122(4 Suppl 2): S14–S20. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Sobolewski P, Sledzińska M, Szczuchniak W, Grzesik M, Sobota A and Hatalska-Zerebiec R: Intravenous thrombolysis patients with acute ischemic stroke - the analysis of the 100 cases. Part II. Neuroimaging, the analysis of hemorrhagic complications and deaths. Przegl Lek. 69:242–246. 2012.(In Polish).

5 

Kenet G, Lütkhoff LK, Albisetti M, et al: Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies. Circulation. 121:1838–1847. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Stanley NC: Preventing recurrent ischemic stroke: a 3-step plan. J Fam Pract. 54:412–422. 2005.PubMed/NCBI

7 

Pikija S, Cvetko D, Malojčić B, et al: A population-based prospective 24-month study of stroke: incidence and 30-day case-fatality rates of first-ever strokes in Croatia. Neuroepidemiology. 38:164–171. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Fisher M and Ginsberg M: Current concepts of the ischemic penumbra. Stroke. 35:2657–2658. 2004. View Article : Google Scholar

9 

González RG: Imaging-guided acute ischemic stroke therapy: from ‘time is brain’ to ‘physiology is brain’. AJNR Am J Neuroradiol. 27:728–735. 2006.

10 

Tirschwell DL, Coplin WM, Becker KJ, et al: Intra-arterial urokinase for acute ischemic stroke: factors associated with complications. Neurology. 57:1100–1103. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Lee RS, Ok YC, Lim JS, Lim BC, Cho KY and Lee MC: Outcome evaluation of intravenous infusion of urokinase for acute ischemic stroke. Chonnam Med J. 48:52–56. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Macleod MR, Davis SM, Mitchell PJ, et al: Results of a multi-centre, randomised controlled trial of intra-arterial urokinase in the treatment of acute posterior circulation ischaemic stroke. Cerebrovasc Dis. 20:12–17. 2005. View Article : Google Scholar

13 

Levi CR, Selmes C and Chambers BR: Transcranial ultrasound-clinical applications in cerebral ischaemia. Australian Prescriber. 24:137–140. 2001.

14 

Cerebrovascular Disease Treatment Group of the Third People’s Hospital of Luoyang City, Henan Province: Clinical analysis of 1005 cases of hemiplegia caused by ultrasound treatment of cerebrovascular disease. Chinese Journal of Internal Medicine. 16:2201976.

15 

Trubestein R, Engel HR, Ezel F, et al: Thrombolysis by ultrasound. Clin Sci Mol Med. 51:697–698. 1976.

16 

Mitragotri S, Blankschtein D and Langer R: Transdermal drug delivery using low-frequency sonophoresis. Pharm Res. 13:411–420. 1996. View Article : Google Scholar : PubMed/NCBI

17 

Daffertshofer M, Gass A, Ringleb P, et al: Transcranial low-frequency ultrasound-mediated thrombolysis in brain ischemia. Stroke. 36:1441–1446. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Cherniavsky EA, Strakha IS, Adzerikho IE and Shkumatov VM: Effects of low frequency ultrasound on some properties of fibrinogen and its plasminolysis. BMC Biochem. 12:602011. View Article : Google Scholar : PubMed/NCBI

19 

Meunier JM, Holland CK, Pancioli AM, Lindsell CJ and Shaw GJ: Effect of low frequency ultrasound on combined rt-PA and eptifibatide thrombolysis in human clots. Thromb Res. 123:528–536. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Fang J, Fang C, Sung KC and Chen H: Effect of low frequency ultrasound on the in vitro percutaneous absorption of clobetasol 17-propionate. Int J Pharm. 191:33–42. 1999. View Article : Google Scholar : PubMed/NCBI

21 

Emerson PF, Ruan J, McLaughlin BE, Keshaviah PR, DeLeo MA and Piscopo D: Effect of low-frequency ultrasound on peritoneal transport in rabbits. Adv Perit Dial. 13:77–80. 1997.PubMed/NCBI

22 

Hitchcock KE and Holland CK: Ultrasound-assisted thrombolysis for stroke therapy: better thrombus break-up with bubbles. Stroke. 41:S50–S53. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Francis CW and Suchkova VN: Ultrasound and thrombolysis. Vasc Med. 6:181–187. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Meunier JM, Holland CK, Porter TM, Lindsell CJ and Shaw GJ: Combination treatment with rt-PA is more effective than rt-PA alone in an in vitro human clot model. Curr Neurovasc Res. 8:305–312. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Zhang Z, Xue Y, Liu Y and Shang X: Additive effect of low-frequency ultrasound and endothelial monocyte-activating polypeptide II on blood-tumor barrier in rats with brain glioma. Neurosci Lett. 481:21–25. 2010. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Gao X: A clinical study of transcranial ultrasound as an adjuvant therapy for progressive cerebral infarction. Exp Ther Med 5: 1244-1246, 2013.
APA
Gao, X. (2013). A clinical study of transcranial ultrasound as an adjuvant therapy for progressive cerebral infarction. Experimental and Therapeutic Medicine, 5, 1244-1246. https://doi.org/10.3892/etm.2013.965
MLA
Gao, X."A clinical study of transcranial ultrasound as an adjuvant therapy for progressive cerebral infarction". Experimental and Therapeutic Medicine 5.4 (2013): 1244-1246.
Chicago
Gao, X."A clinical study of transcranial ultrasound as an adjuvant therapy for progressive cerebral infarction". Experimental and Therapeutic Medicine 5, no. 4 (2013): 1244-1246. https://doi.org/10.3892/etm.2013.965
Copy and paste a formatted citation
x
Spandidos Publications style
Gao X: A clinical study of transcranial ultrasound as an adjuvant therapy for progressive cerebral infarction. Exp Ther Med 5: 1244-1246, 2013.
APA
Gao, X. (2013). A clinical study of transcranial ultrasound as an adjuvant therapy for progressive cerebral infarction. Experimental and Therapeutic Medicine, 5, 1244-1246. https://doi.org/10.3892/etm.2013.965
MLA
Gao, X."A clinical study of transcranial ultrasound as an adjuvant therapy for progressive cerebral infarction". Experimental and Therapeutic Medicine 5.4 (2013): 1244-1246.
Chicago
Gao, X."A clinical study of transcranial ultrasound as an adjuvant therapy for progressive cerebral infarction". Experimental and Therapeutic Medicine 5, no. 4 (2013): 1244-1246. https://doi.org/10.3892/etm.2013.965
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