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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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2014-March Volume 7 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Effects of the antihypertensive drug benidipine on osteoblast function in vitro

  • Authors:
    • Baixiang Wang
    • Ming Bi
    • Zhen Zhu
    • Lei Wu
    • Jingyun Wang
  • View Affiliations / Copyright

    Affiliations: Department of Prosthodontics, School of Stomatology, Jilin University, Changchun, Jilin 130021, P.R. China, Department of and Comprehensive Treatment, School of Stomatology, Jilin University, Changchun, Jilin 130021, P.R. China, Department of Prosthodontics, Zhenjiang Stomatological Hospital, Zhenjiang, Jiangsu 212002, P.R. China, Department of Prosthodontics, School of Stomatology, Jilin University, Changchun, Jilin 130021, P.R. China
  • Pages: 649-653
    |
    Published online on: January 3, 2014
       https://doi.org/10.3892/etm.2014.1475
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Abstract

The dihydropyridine‑type calcium channel blocker, benidipine (BD) has been widely used in hypertension therapy. Previous studies have demonstrated that BD has a positive effect on bone metabolism. Inspired by this promoting phenomenon, the present study investigated the effects of BD on osteoblasts in vitro. Experiments were designed and performed, including an MTT assay, reverse transcription‑polymerase chain reaction, western blot analysis, alkaline phosphatase activity measurements and alizarin red S staining. The results demonstrated that BD promoted osteoblast proliferation and osteogenic differentiation at concentrations from 1x10‑6 to 1x10‑9 M by upregulating Runx2, BMP2 and OCN gene expression levels. Overall, BD at appropriate concentrations has been demonstrated to have positive effects on osteoblast function in addition to its conventional clinical usage.
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Copy and paste a formatted citation
Spandidos Publications style
Wang B, Bi M, Zhu Z, Wu L and Wang J: Effects of the antihypertensive drug benidipine on osteoblast function in vitro. Exp Ther Med 7: 649-653, 2014.
APA
Wang, B., Bi, M., Zhu, Z., Wu, L., & Wang, J. (2014). Effects of the antihypertensive drug benidipine on osteoblast function in vitro. Experimental and Therapeutic Medicine, 7, 649-653. https://doi.org/10.3892/etm.2014.1475
MLA
Wang, B., Bi, M., Zhu, Z., Wu, L., Wang, J."Effects of the antihypertensive drug benidipine on osteoblast function in vitro". Experimental and Therapeutic Medicine 7.3 (2014): 649-653.
Chicago
Wang, B., Bi, M., Zhu, Z., Wu, L., Wang, J."Effects of the antihypertensive drug benidipine on osteoblast function in vitro". Experimental and Therapeutic Medicine 7, no. 3 (2014): 649-653. https://doi.org/10.3892/etm.2014.1475
Copy and paste a formatted citation
x
Spandidos Publications style
Wang B, Bi M, Zhu Z, Wu L and Wang J: Effects of the antihypertensive drug benidipine on osteoblast function in vitro. Exp Ther Med 7: 649-653, 2014.
APA
Wang, B., Bi, M., Zhu, Z., Wu, L., & Wang, J. (2014). Effects of the antihypertensive drug benidipine on osteoblast function in vitro. Experimental and Therapeutic Medicine, 7, 649-653. https://doi.org/10.3892/etm.2014.1475
MLA
Wang, B., Bi, M., Zhu, Z., Wu, L., Wang, J."Effects of the antihypertensive drug benidipine on osteoblast function in vitro". Experimental and Therapeutic Medicine 7.3 (2014): 649-653.
Chicago
Wang, B., Bi, M., Zhu, Z., Wu, L., Wang, J."Effects of the antihypertensive drug benidipine on osteoblast function in vitro". Experimental and Therapeutic Medicine 7, no. 3 (2014): 649-653. https://doi.org/10.3892/etm.2014.1475
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