Xenogenic (porcine) acellular dermal matrix is useful for the wound healing of severely damaged extremities

Zhang,Zhaoxin; Lv,Lei; Mamat,Masut; Chen,Zhao; Liu,Lihua; Wang,Zhizhong

doi:10.3892/etm.2014.1490

2014-March Volume 7 Issue 3

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2014-March Volume 7 Issue 3

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Article

Xenogenic (porcine) acellular dermal matrix is useful for the wound healing of severely damaged extremities

Authors:
- Zhaoxin Zhang
- Lei Lv
- Masut Mamat
- Zhao Chen
- Lihua Liu
- Zhizhong Wang
View Affiliations / Copyright

Affiliations: Department of Burn and Wound Repair Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang 830021, P.R. China
Pages: 621-624
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Published online on: January 20, 2014

https://doi.org/10.3892/etm.2014.1490
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Abstract

This study was conducted to investigate the possibility of improving the success rate of patient treatment and promoting wound healing by utilizing xenogenic (porcine) acellular dermal matrix (XADM) to cover large areas of severely damaged wounds. Patients with severely damaged large‑area wounds (56 cases) were enrolled in the study from May 2002 to May 2012. All patients admitted to hospital received a rapid infusion via intravenous access to maintain an effective circulating blood volume and to correct disorders of water and electrolytes. The wounds were exposed and covered with XADM during the initial surgery. All patients subsequently received secondary stage surgery. Of the patients, 47 cases received an autologous skin graft for wound closure, six cases underwent wound repair with a local flap and three cases underwent wound repair with an axial flap. There were two cases of amputation and three cases of mortality. The cases of two of the patients are described in detail. XADM was demonstrated to reduce the risk of emergency during surgery and improve the success rate of wound healing and patient treatment.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Xenogenic (porcine) acellular dermal matrix is useful for the wound healing of severely damaged extremities

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