|
1
|
Vaupel P, Höckel M and Mayer A: Detection
and characterization of tumor hypoxia using pO2
histography. Antioxid Redox Signal. 9:1221–1235. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Höckel M and Vaupel P: Tumor hypoxia:
definitions and current clinical, biologic, and molecular aspects.
J Natl Cancer Inst. 93:266–276. 2001.PubMed/NCBI
|
|
3
|
Guillemin K and Krasnow MA: The hypoxic
response: huffing and HIFing. Cell. 89:9–12. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Semenza GL: Targeting HIF-1 for cancer
therapy. Nat Rev Cancer. 3:721–732. 2003. View Article : Google Scholar
|
|
5
|
Poon E, Harris AL and Ashcroft M:
Targeting the hypoxia-inducible factor (HIF) pathway in cancer.
Expert Rev Mol Med. 11:e262009. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Wang GL, Jiang BH, Rue EA and Semenza GL:
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS
heterodimer regulated by cellular O2 tension. Proc Natl
Acad Sci USA. 92:5510–5514. 1995. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Schofield CJ and Ratcliffe PJ: Oxygen
sensing by HIF hydroxylases. Nat Rev Mol Cell Biol. 5:343–354.
2004. View
Article : Google Scholar : PubMed/NCBI
|
|
8
|
Semenza GL: Regulation of mammalian
O2 homeostasis by hypoxia-inducible factor 1. Annu Rev
Cell Dev Biol. 15:551–578. 1999.
|
|
9
|
Jiang BH, Rue E, Wang GL, Roe R and
Semenza GL: Dimerization, DNA binding, and transactivation
properties of hypoxia-inducible factor 1. J Biol Chem.
271:17771–17778. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Semenza GL: Targeting HIF-1 for cancer
therapy. Nat Rev Cancer. 3:721–732. 2003. View Article : Google Scholar
|
|
11
|
Ivan M, Kondo K, Yang H, Kim W, Valiando
J, Ohh M, Salic A, Asara JM, Lane WS and Kaelin WG Jr: HIFalpha
targeted for VHL-mediated destruction by proline hydroxylation:
implications for O2 sensing. Science. 292:464–468. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Maxwell PH, Wiesener MS, Chang GW,
Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER and
Ratcliffe PJ: The tumour suppressor protein VHL targets
hypoxia-inducible factors for oxygen-dependent proteolysis. Nature.
399:271–275. 1999. View
Article : Google Scholar : PubMed/NCBI
|
|
13
|
Semenza GL: HIF-1, O(2), and the 3 PHDs:
how animal cells signal hypoxia to the nucleus. Cell. 107:1–3.
2001.PubMed/NCBI
|
|
14
|
Kallio PJ, Okamoto K, O’Brien S, Carrero
P, Makino Y, Tanaka H and Poellinger L: Signal transduction in
hypoxic cells: inducible nuclear translocation and recruitment of
the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha.
EMBO J. 17:6573–6586. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Bos R, Zhong H, Hanrahan CF, Mommers EC,
Semenza GL, Pinedo HM, Abeloff MD, Simons JW, van Diest PJ and van
der Wall E: Levels of hypoxia-inducible factor-1 alpha during
breast carcinogenesis. J Natl Cancer Inst. 93:309–314. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Zhong H, De Marzo AM, Laughner E, Lim M,
Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL and Simons
JW: Overexpression of hypoxia-inducible factor 1alpha in common
human cancers and their metastases. Cancer Res. 59:5830–5835.
1999.PubMed/NCBI
|
|
17
|
Cheng ZX, Sun B, Wang SJ, Gao Y, Zhang YM,
Zhou HX, Jia G, Wang YW, Kong R, Pan SH, Xue DB, Jiang HC and Bai
XW: Nuclear Factor-κB-dependent epithelial to mesenchymal
transition induced by HIF-1α activation in pancreatic cancer cells
under hypoxic conditions. PLoS One. 6:e237522011.
|
|
18
|
Thiery JP and Sleeman JP: Complex networks
orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell
Biol. 7:131–142. 2006. View
Article : Google Scholar : PubMed/NCBI
|
|
19
|
Thiery JP, Acloque H, Huang RY and Nieto
MA: Epithelial-mesenchymal transitions in development and disease.
Cell. 139:871–890. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Kalluri R and Weinberg RA: The basics of
epithelial-mesenchymal transition. J Clin Invest. 119:1420–1428.
2009. View
Article : Google Scholar : PubMed/NCBI
|
|
21
|
Turley EA, Veiseh M, Radisky DC and
Bissell MJ: Mechanisms of disease: epithelial-mesenchymal
transition - does cellular plasticity fuel neoplastic progression?
Nat Clin Pract Oncol. 5:280–290. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Bates RC and Mercurio A: The
epithelial-mesenchymal transition (EMT) and colorectal cancer
progression. Cancer Biol Ther. 4:365–370. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Gordaliza M: Natural products as leads to
anticancer drugs. Clin Transl Oncol. 9:767–776. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Ji HF, Li XJ and Zhang HY: Natural
products and drug discovery. Can thousands of years of ancient
medical knowledge lead us to new and powerful drug combinations in
the fight against cancer and dementia? EMBO Rep. 10:194–200.
2009.PubMed/NCBI
|
|
25
|
Chinese Pharmacopoeia Commission.
Pharmacopoeia of the People’s Republic of China. 1. Chinese Medical
Science and Technology Press; Beijing: pp. 573–575. 2010
|
|
26
|
Lin JM, Wei LH, Chen YQ, Liu XX, Hong ZF,
Sferra TJ and Peng J: Pien Tze Huang induced apoptosis in human
colon cancer HT-29 cells is associated with regulation of the Bcl-2
family and activation of caspase 3. Chin J Integr Med. 17:685–690.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Zhuang Q, Hong F, Shen A, Zheng L, Zeng J,
Lin W, Chen Y, Sferra T, Hong Z and Peng J: Pien Tze Huang inhibits
tumor cell proliferation and promotes apoptosis via suppressing the
STAT3 pathway in a colorectal cancer mouse model. Int J Oncol.
40:1569–1574. 2012.PubMed/NCBI
|
|
28
|
Shen AL, Hong F, Liu LY, Lin JM, Zhuang
QC, Hong ZF and Peng J: Effects of Pien Tze Huang on angiogenesis
in vivo and in vitro. Chin J Integr Med. 18:431–436. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Shen A, Hong F, Liu L, Lin J, Wei L, Cai
Q, Hong Z and Peng J: Pien Tze Huang inhibits the proliferation of
human colon carcinoma cells by arresting G1/S cell cycle
progression. Oncol Lett. 4:767–770. 2012.PubMed/NCBI
|
|
30
|
Shen A, Chen Y, Hong F, Lin J, Wei L, Hong
Z, Sferra TJ and Peng J: Pien Tze Huang suppresses IL-6-inducible
STAT3 activation in human colon carcinoma cells through induction
of SOCS3. Oncol Rep. 28:2125–2130. 2012.PubMed/NCBI
|
|
31
|
Shen A, Lin J, Chen Y, Lin W, Liu L, Hong
ZF, Sferra TJ and Peng J: Pien Tze Huang inhibits tumor
angiogenesis in a mouse model of colorectal cancer via suppression
of multiple cellular pathways. Oncol Rep. 30:1701–1706.
2013.PubMed/NCBI
|
