Sonographic measurement of renal size in patients undergoing chronic hemodialysis: Correlation with residual renal function

Zhang,Wu‑Xing; Zhang,Zhi‑Min; Cao,Bing‑Sheng; Zhou,Wei

doi:10.3892/etm.2014.1560

Sonographic measurement of renal size in patients undergoing chronic hemodialysis: Correlation with residual renal function

Authors:
- Wu‑Xing Zhang
- Zhi‑Min Zhang
- Bing‑Sheng Cao
- Wei Zhou
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Affiliations: Department of Nephrology, PLA Center of Transplantation, PLA 309th Hospital, Beijing 100091, P.R. China, Department of Ultrasound, PLA 309th Hospital, Beijing 100091, P.R. China
Published online on: February 19, 2014 https://doi.org/10.3892/etm.2014.1560
Pages: 1259-1264

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Abstract

Previous studies have reported that renal size may change when the function is compromised. However, it is not known whether sonographically measured renal size reflects the residual renal function (RRF) in patients undergoing chronic hemodialysis. A total of 140 patients undergoing chronic hemodialysis (≥3 months) were investigated in the present study. The patients were divided into two groups according to the daily urine volume: Individuals with RRF (RRF+ group; ≥200 ml; n=65) and without RRF (RRF‑ group; <200 ml; n=75). Renal sizes were measured using sonography and renal volumes were calculated with the ellipsoid formula. Univariable and multivariable stepwise forward logistic regression analyses were performed to examine the correlation between the presence of RRF and various variables. The results indicated that there were statistically significant differences (P<0.001) between the RRF+ and RRF‑ groups with regard to renal length, width, thickness and volume of the left (length, 7.9±1.2 vs. 6.8±1.2 cm; volume, 60.0±26.7 vs. 40.2±18.1 ml, respectively) and right (length, 7.6±1.2 vs. 6.7±1.2 cm; volume, 50.2±26.5 vs. 33.9±15.3 ml, respectively) sides of the kidney. Multivariable stepwise forward logistic regression analyses showed that the mean renal length or volume and hemodialysis duration were independent predictors of the presence of RRF. Therefore, renal size assessment by ultrasonography may be useful for RRF evaluation in patients undergoing chronic hemodialysis.

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1	Brener ZZ, Kotanko P, Thijssen S, et al: Clinical benefit of preserving residual renal function in dialysis patients: an update for clinicians. Am J Med Sci. 339:453–456. 2010.PubMed/NCBI
2	Artunc F and Risler T: Serum erythropoietin concentrations and responses to anaemia in patients with or without chronic kidney disease. Nephrol Dial Transplant. 22:2900–2908. 2007. View Article : Google Scholar : PubMed/NCBI
3	Viaene L, Bammens B, Meijers BK, et al: Residual renal function is an independent determinant of serum FGF-23 levels in dialysis patients. Nephrol Dial Transplant. 27:2017–2022. 2012. View Article : Google Scholar : PubMed/NCBI
4	Wang AY, Lam CW, Wang M, et al: Is valvular calcification a part of the missing link between residual kidney function and cardiac hypertrophy in peritoneal ddialysis patients? Clin J Am Soc Nephrol. 4:1629–1636. 2009. View Article : Google Scholar : PubMed/NCBI
5	Thomas J and Teitelbaum I: Preservation of residual renal function in dialysis patients. Adv Perit Dial. 27:112–117. 2011.PubMed/NCBI
6	Gerhardt T, Pöge U, Stoffel-Wagner B, et al: Serum levels of beta-trace protein and its association to diuresis in haemodialysis patients. Nephrol Dial Transplant. 23:309–314. 2008. View Article : Google Scholar : PubMed/NCBI
7	Perl J and Bargman JM: The importance of residual kidney function for patients on dialysis: a critical review. Am J Kidney Dis. 53:1068–1081. 2009. View Article : Google Scholar : PubMed/NCBI
8	van der Wal WM, Noordzij M, Dekker FW, et al; Netherlands Cooperative Study on the Adequacy of Dialysis Study Group (NECOSAD). Full loss of residual renal function causes higher mortality in dialysis patients; findings from a marginal structural model. Nephrol Dial Transplant. 26:2978–2983. 2011.PubMed/NCBI
9	Frank M, Guarino-Gubler S, Burnier M, et al: Estimation of glomerular filtration rate in hospitalised patients: are we overestimating renal function? Swiss Med Wkly. 142:w137082012.PubMed/NCBI
10	Paleologo G, Abdelkawy H, Barsotti M, et al: Kidney dimensions at sonography are correlated with glomerular filtration rate in renal transplant recipients and in kidney donors. Transplant Proc. 39:1779–1781. 2007. View Article : Google Scholar : PubMed/NCBI
11	Moist LM, Port FK, Orzol SM, et al: Predictors of loss of residual renal function among new dialysis patients. J Am Soc Nephrol. 11:556–564. 2000.PubMed/NCBI
12	Suda T, Hiroshige K, Ohta T, et al: The contribution of residual renal function to overall nutritional status in chronic haemodialysis patients. Nephrol Dial Transplant. 15:396–401. 2000. View Article : Google Scholar : PubMed/NCBI
13	Erkan E, Moritz M and Kaskel F: Impact of residual renal function in children on hemodialysis. Pediatr Nephrol. 16:858–861. 2001. View Article : Google Scholar : PubMed/NCBI
14	Richardson D, Lindley EJ and Will EJ: A randomized, controlled study of the consequences of hemodialysis membrane composition on erythropoietic response. Am J Kidney Dis. 42:551–560. 2003. View Article : Google Scholar : PubMed/NCBI
15	Dervisoglu E, Altun EA, Kalender B and Caglayan C: Effects of residual renal function on clinical and laboratory features of patients on continuous ambulatory peritoneal dialysis. BANTAO Journal. 5:36–39. 2007.
16	Bragg-Gresham JL, Fissell RB, Mason NA, et al: Diuretic use, residual renal function, and mortality among hemodialysis patients in the Dialysis Outcomes and Practice Pattern Study (DOPPS). Am J Kidney Dis. 49:426–431. 2007. View Article : Google Scholar
17	Khalil AA, Frazier SK, Lennie TA and Sawaya BP: Depressive symptoms and dietary adherence in patients with end-stage renal disease. J Ren Care. 37:30–39. 2011. View Article : Google Scholar
18	Miletić D, Fuckar Z, Sustić A, et al: Sonographic measurement of absolute and relative renal length in adults. J Clin Ultrasound. 26:185–189. 1998.PubMed/NCBI
19	Sanusi AA, Arogundade FA, Famurewa OC, et al: Relationship of ultrasonographically determined kidney volume with measured GFR, calculated creatinine clearance and other parameters in chronic kidney disease (CKD). Nephrol Dial Transplant. 24:1690–1694. 2009.
20	Van Den Noortgate N, Velghe A, Petrovic M, et al: The role of ultrasonography in the assessment of renal function in the elderly. J Nephrol. 16:658–662. 2003.
21	Kim HC, Yang DM, Jin W and Lee SH: Relation between total renal volume and renal function: usefulness of 3D sonographic measurements with a matrix array transducer. AJR Am J Roentgenol. 194:W186–W192. 2010.PubMed/NCBI
22	Adibi A, Adibi I and Khosravi P: Do kidney sizes in ultrasonography correlate to glomerular filtration rate in healthy children? Australas Radiol. 51:555–559. 2007. View Article : Google Scholar : PubMed/NCBI
23	Emamian SA, Nielsen MB, Pedersen JF and Ytte L: Kidney dimensions at sonography: correlation with age, sex, and habitus in 665 adult volunteers. AJR Am J Roentgenol. 160:83–86. 1993. View Article : Google Scholar : PubMed/NCBI
24	Brandt TD, Neiman HL, Dragowski MJ, et al: Ultrasound assessment of normal renal dimensions. J Ultrasound Med. 1:49–52. 1982.PubMed/NCBI
25	Cheong B, Muthupillai R, Rubin MF and Flamm SD: Normal values for renal length and volume as measured by magnetic resonance imaging. Clin J Am Soc Nephrol. 2:38–45. 2007.PubMed/NCBI
26	Shemin D, Bostom AG, Laliberty P and Dworkin LD: Residual renal function and mortality risk in hemodialysis patients. Am J Kidney Dis. 38:85–90. 2001. View Article : Google Scholar : PubMed/NCBI
27	Hetakeyama S, Abe A, Suzuki T, et al: Clearance and safety of the radiocontrast medium iopamidol in peritoneal dialysis patients. Int J Nephrol. 2011:6570512011.PubMed/NCBI