Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
May-2014 Volume 7 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2014 Volume 7 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Correlation between the severity of coronary artery lesions and levels of estrogen, hs‑CRP and MMP‑9

  • Authors:
    • Changlei Guo
    • Shaoli Zhang
    • Junbiao Zhang
    • Hui Liu
    • Peicheng Li
    • Hengdao Liu
    • Yakun Wang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Internal Medicine, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, P.R. China
  • Pages: 1177-1180
    |
    Published online on: February 20, 2014
       https://doi.org/10.3892/etm.2014.1565
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of this study was to investigate the correlation between the severity of coronary artery lesions in patients with acute coronary syndromes (ACS) and levels of estrogen, high‑sensitivity C‑reactive protein (hs‑CRP) and matrix metalloproteinase‑9 (MMP‑9). A total of 65 patients with ACS, 33 patients with stable angina pectoris (SAP) and 36 healthy controls were randomly enrolled. Patients with ACS were subdivided into two groups: Acute myocardial infarction (AMI; n=30) and unstable angina pectoris (UAP; n=35). Serum levels of estrogen, hs‑CRP and MMP‑9 were detected in the four groups of subjects. Serum estrogen levels in patients with AMI, UAP and SAP were significantly lower than those in the control group (P<0.05). Estrogen levels were also significantly different among the AMI, UAP and SAP groups (P<0.05), with a progressive increase across the three respective groups. Compared with healthy subjects, patients with AMI had the highest levels of hs‑CRP and MMP‑9, followed in descending order by those with UAP and SAP (P<0.05). Levels of hs‑CRP and MMP‑9 were also significantly different among the AMI, UAP and SAP groups (P<0.05). Serum estrogen levels were negatively correlated with hs‑CRP and MMP‑9 levels (r=-0.6634 and -0.6878, respectively; both P<0.05). hs‑CRP and MMP‑9 levels correlated positively (r=0.7208, P<0.05). The number of stenosed coronary vessels was negatively correlated with estrogen levels (r=‑0.6467, P<0.05), and positively correlated with hs‑CRP and MMP‑9 levels (r=0.6519 and 0.6835, respectively; both P<0.05). In conclusion, serum estrogen, hs‑CRP and MMP‑9 levels were significantly correlated with the severity of coronary artery lesions. There was also a significant correlation between serum estrogen, hs‑CRP and MMP‑9 levels. These data indicate that serum estrogen, hs‑CRP and MMP‑9 have the potential to be used as biomarkers for evaluating the severity of coronary artery lesions and the stability of coronary artery plaques.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Harutyunyan M, Gøtze JP, Winkel P, et al: Serum YKL-40 predicts long-term mortality in patients with stable coronary disease: a prognostic study within the CLARICOR trial. Immunobiology. 218:945–951. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Falcone C, Lucibello S, Mazzucchelli I, et al: Galectin-3 plasma levels and coronary artery disease: a new possible biomarker of acute coronary syndrome. Int J Immunopathol Pharmacol. 24:905–913. 2011.PubMed/NCBI

3 

Sakamoto Y, Muramatsu T, Tsukahara R, Ito Y, Ishimori H, Hirano K and Nakano M: A case achieved successful revascularization to severe ischemic coronary artery disease after endovascular recanalization with infrarenal aortic occlusion. Cardiovasc Interv Ther. 27:93–98. 2012. View Article : Google Scholar

4 

Oh JE, Kim YW, Park SY and Kim JY: Estrogen rather than progesterone cause constipation in both female and male mice. Korean J Physiol Pharmacol. 17:423–426. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Seo SM, Baek SH, Jeon HK, et al: Correlations between the level of high-sensitivity c-reactive protein and cardiovascular risk factors in korean adults with cardiovascular disease or diabetes mellitus: the CALLISTO study. J Atheroscler Thromb. 20:616–622. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Yabluchanskiy A, Ma Y, Iyer RP, Hall ME and Lindsey ML: Matrix metalloproteinase-9: Many shades of function in cardiovascular disease. Physiology (Bethesda). 28:391–403. 2013.PubMed/NCBI

7 

Duellman T, Warren CL, Peissig P, Wynn M and Yang J: Matrix metalloproteinase-9 genotype as a potential genetic marker for abdominal aortic aneurysm. Circ Cardiovasc Genet. 5:529–537. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Miller VM, Petterson TM, Jeavons EN, et al: Genetic polymorphisms associated with carotid artery intima-media thickness and coronary artery calcification in women of the Kronos Early Estrogen Prevention Study. Physiol Genomics. 45:79–88. 2013. View Article : Google Scholar

9 

Rashidinejad H, Hosseini SM, Moazenzadeh M, Azimzadeh BS, Mirzaeipour F, Fakhreddini K and Sheikhvatan M: Relationship between serum level of high-sensitive C-reactive protein and extension of myocardial involvement in patients with acute myocardial infarction. Rom J Intern Med. 50:211–215. 2012.PubMed/NCBI

10 

Golovkin AS, Matveeva VG, Grigor’ev EV, Baĭrakova IuV, Shukevich DL, Velikanova EA and Barbarash OL: Postoperative dynamic changes in matrix metalloproteinase levels in patients with coronary artery bypass graft procedure complications. Kardiologiia. 52:4–7. 2012.(In Russian).

11 

Salama MM, Morad AR, Saleh MA, Sabri NA, Zaki MM and ElSafady LA: Resistance to low-dose aspirin therapy among patients with acute coronary syndrome in relation to associated risk factors. J Clin Pharm Ther. 37:630–636. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Kehl DW, Iqbal N, Fard A, Kipper BA, De La Parra Landa A and Maisel AS: Biomarkers in acute myocardial injury. Transl Res. 159:252–264. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Cristell N, Cianflone D, Durante A, et al: High-sensitivity C-reactive protein is within normal levels at the very onset of first ST-segment elevation acute myocardial infarction in 41% of cases: a multiethnic case-control study. J Am Coll Cardiol. 58:2654–2661. 2011.PubMed/NCBI

14 

Akhtar N, Adil MM, Ahmed W, Habib-ur-Rehman and Shahs MA: The role of leukocyte counts in patients with unstable angina pectoris or myocardial infarction; prognostic significance and correlation with plasma brain natriuretic peptide (BNP) levels. J Pak Med Assoc. 61:51–54. 2011.

15 

Huang G, Wang D, Zeb I, et al: Intra-thoracic fat, cardiometabolic risk factors, and subclinical cardiovascular disease in healthy, recently menopausal women screened for the Kronos Early Estrogen Prevention Study (KEEPS). Atherosclerosis. 221:198–205. 2012. View Article : Google Scholar

16 

Mirhosseini SJ, Forouzannia SK, Ali-Hassan-Sayegh S, Ravan HV, Abdollahi MH and Mozayan MR: Preoperative C-reactive protein can predict early clinical outcomes following elective off-pump CABG surgery in patients with severe left ventricle dysfunction. Saudi J Anaesth. 6:327–331. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Crăciunescu I, Serban M, Iancu M, et al: Changes in plasma levels of MMP-9, MMP-7 and their inhibitors in patients with coronary artery disease. Rom J Intern Med. 48:141–149. 2010.PubMed/NCBI

18 

Park JP, Lee BK, Shim JM, Kim SH, Lee CW, Kang DH and Hong MK: Relationship between multiple plasma biomarkers and vulnerable plaque determined by virtual histology intravascular ultrasound. Circ J. 74:332–336. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Datta S, Iqbal Z and Prasad KR: Comparison between serum hsCRP and LDL cholesterol for search of a better predictor for ischemic heart disease. Indian J Clin Biochem. 26:210–213. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Guo C, Zhang S, Zhang J, Liu H, Li P, Liu H and Wang Y: Correlation between the severity of coronary artery lesions and levels of estrogen, hs‑CRP and MMP‑9. Exp Ther Med 7: 1177-1180, 2014.
APA
Guo, C., Zhang, S., Zhang, J., Liu, H., Li, P., Liu, H., & Wang, Y. (2014). Correlation between the severity of coronary artery lesions and levels of estrogen, hs‑CRP and MMP‑9. Experimental and Therapeutic Medicine, 7, 1177-1180. https://doi.org/10.3892/etm.2014.1565
MLA
Guo, C., Zhang, S., Zhang, J., Liu, H., Li, P., Liu, H., Wang, Y."Correlation between the severity of coronary artery lesions and levels of estrogen, hs‑CRP and MMP‑9". Experimental and Therapeutic Medicine 7.5 (2014): 1177-1180.
Chicago
Guo, C., Zhang, S., Zhang, J., Liu, H., Li, P., Liu, H., Wang, Y."Correlation between the severity of coronary artery lesions and levels of estrogen, hs‑CRP and MMP‑9". Experimental and Therapeutic Medicine 7, no. 5 (2014): 1177-1180. https://doi.org/10.3892/etm.2014.1565
Copy and paste a formatted citation
x
Spandidos Publications style
Guo C, Zhang S, Zhang J, Liu H, Li P, Liu H and Wang Y: Correlation between the severity of coronary artery lesions and levels of estrogen, hs‑CRP and MMP‑9. Exp Ther Med 7: 1177-1180, 2014.
APA
Guo, C., Zhang, S., Zhang, J., Liu, H., Li, P., Liu, H., & Wang, Y. (2014). Correlation between the severity of coronary artery lesions and levels of estrogen, hs‑CRP and MMP‑9. Experimental and Therapeutic Medicine, 7, 1177-1180. https://doi.org/10.3892/etm.2014.1565
MLA
Guo, C., Zhang, S., Zhang, J., Liu, H., Li, P., Liu, H., Wang, Y."Correlation between the severity of coronary artery lesions and levels of estrogen, hs‑CRP and MMP‑9". Experimental and Therapeutic Medicine 7.5 (2014): 1177-1180.
Chicago
Guo, C., Zhang, S., Zhang, J., Liu, H., Li, P., Liu, H., Wang, Y."Correlation between the severity of coronary artery lesions and levels of estrogen, hs‑CRP and MMP‑9". Experimental and Therapeutic Medicine 7, no. 5 (2014): 1177-1180. https://doi.org/10.3892/etm.2014.1565
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team