Glycyrrhizin protects mice against renal ischemia‑reperfusion injury through inhibition of apoptosis and inflammation by downregulating p38 mitogen‑activated protein kinase signaling

  • Authors:
    • Shaojun Ye
    • Yi Zhu
    • Yingzi Ming
    • Xingguo She
    • Hong Liu
    • Qifa Ye
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  • Published online on: February 21, 2014     https://doi.org/10.3892/etm.2014.1570
  • Pages: 1247-1252
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Abstract

Ischemia‑reperfusion (I/R) often leads to acute kidney injury, chronic renal failure and kidney transplantation failure. Glycyrrhizin is extracted from Glycyrrhiza glabra roots and is the predominant active component, which exhibits anti‑inflammatory effects. However, to the best of our knowledge, the effect of glycyrrhizin on I/R‑induced renal injury has not been investigated. In the present study, glycyrrhizin was demonstrated to attenuate renal I/R injury in mice via administration of glycyrrhizin, which suppressed the serum levels of creatinine and blood urea nitrogen 6 h following reperfusion; furthermore, the superoxide anions as well as the activity of superoxide dismutase within renal tissues was reduced by glycyrrhizin pretreatment. Moreover, the protein level of cleaved caspase‑3, as well as its activity in renal tissue, was suppressed as a result of the glycyrrhizin pretreatment, indicating that glycyrrhizin inhibits I/R‑induced renal cell apoptosis. In addition, glycyrrhizin pretreatment appeared to ameliorate I/R‑induced renal injury via inhibition of inflammatory cell infiltration, as well as the production of pro‑inflammatory cytokines, including tumor necrosis factor‑α, interferon‑γ, interleukin (IL)‑1β and IL‑6. The underlying molecular mechanism was investigated and it was shown that the activity of p38 mitogen‑activated protein kinase signaling was downregulated as a result of glycyrrhizin administration. In conclusion, the present study indicated that glycyrrhizin provided significant protection against I/R‑induced renal injury in mice by inhibiting inflammatory responses and renal cell apoptosis. Therefore, glycyrrhizin may be used in abdominal surgery and kidney transplantation for the prevention of renal I/R damage.
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May-2014
Volume 7 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Ye S, Zhu Y, Ming Y, She X, Liu H and Ye Q: Glycyrrhizin protects mice against renal ischemia‑reperfusion injury through inhibition of apoptosis and inflammation by downregulating p38 mitogen‑activated protein kinase signaling. Exp Ther Med 7: 1247-1252, 2014
APA
Ye, S., Zhu, Y., Ming, Y., She, X., Liu, H., & Ye, Q. (2014). Glycyrrhizin protects mice against renal ischemia‑reperfusion injury through inhibition of apoptosis and inflammation by downregulating p38 mitogen‑activated protein kinase signaling. Experimental and Therapeutic Medicine, 7, 1247-1252. https://doi.org/10.3892/etm.2014.1570
MLA
Ye, S., Zhu, Y., Ming, Y., She, X., Liu, H., Ye, Q."Glycyrrhizin protects mice against renal ischemia‑reperfusion injury through inhibition of apoptosis and inflammation by downregulating p38 mitogen‑activated protein kinase signaling". Experimental and Therapeutic Medicine 7.5 (2014): 1247-1252.
Chicago
Ye, S., Zhu, Y., Ming, Y., She, X., Liu, H., Ye, Q."Glycyrrhizin protects mice against renal ischemia‑reperfusion injury through inhibition of apoptosis and inflammation by downregulating p38 mitogen‑activated protein kinase signaling". Experimental and Therapeutic Medicine 7, no. 5 (2014): 1247-1252. https://doi.org/10.3892/etm.2014.1570