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Article

Effects of a gemcitabine plus platinum regimen combined with a dendritic cell-cytokine induced killer immunotherapy on recurrence and survival rate of non-small cell lung cancer patients

  • Authors:
    • Min Zhao
    • Hongbing Li
    • Lei Li
    • Yijie Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Henan University Huaihe Hospital, Kaifeng, Henan 475000, P.R. China
  • Pages: 1403-1407
    |
    Published online on: February 21, 2014
       https://doi.org/10.3892/etm.2014.1574
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Abstract

The aim of the present study was to investigate the effects of a gemcitabine plus platinum (GP) regimen combined with dendritic cell-cytokine induced killer (DC‑CIK) immunotherapy on the recurrence and survival rate in patients with non-small cell lung cancer (NSCLC). Patients (n=157) with stage Ⅲ NSCLC that had received surgery were randomly divided into a control group and an observation group. The control group was administered with a GP regimen and the observation group received GP chemotherapy that was based on DC‑CIK cell immunotherapy in addition to SC-CIK cell immunotherapy here. The two groups were followed up for 36 months and their postoperative cellular immune function, disease‑free survival time, cumulative recurrence rate and cumulative survival rate was analyzed. The percentages of CD3+CD4+ T lymphocytes, natural killer cells and the CD4/CD8 ratio were identified to be significantly increased following treatment compared with those observed prior to treatment in the control and observation groups; conversely, the CD3+CD8+ T lymphocyte percentage decreased significantly (P<0.05). Furthermore, the results of the patients in the observation group were significantly better compared with the control group based on these indicators (P<0.05). The median disease‑free survival time of patients in the observation group (28 months) was identified to be significantly longer than that of the control group (22 months; P<0.05), the three-year cumulative recurrence rate in the observation group (47.37%) was significantly lower than that of the control group (76.92%; P<0.05) and the three-year cumulative survival rate of the patients in the observation group (58.23%) was significantly higher than that of the control group patients (37.14%; P<0.05). In conclusion, the GP regimen combined with DC‑CIK immunotherapy significantly improved the immune cell function in the postoperative NSCLC patients, in addition to reducing postoperative tumor recurrence and prolonging the survival time of patients with NSCLC.
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1 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2012. CA Cancer J Clin. 62:10–29. 2012. View Article : Google Scholar

2 

Goldstraw P, Ball D, Jett JR, Le Chevalier T, Lim E, Nicholson AG and Shepherd FA: Non-small-cell lung cancer. Lancet. 378:1727–1740. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Naim Younes R, Gross JL, Abrao FG and Rodrigues Pereira J: Impact of adjuvant chemotherapy in completely resected stage IIIA non-small cell lung cancer. Minerva Chir. 68:169–174. 2013.

4 

Filipits M and Pirker R: Predictive markers in the adjuvant therapy of non-small cell lung cancer. Lung Cancer. 74:355–363. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Jemal A, Murray T, Ward E, et al: Cancer statistics, 2005. CA Cancer J Clin. 55:10–30. 2005. View Article : Google Scholar

6 

Pisters KM: Adjuvant chemotherapy for non-small-cell lung cancer - the smoke clears. N Engl J Med. 352:2640–2642. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Ost D, Goldberg J, Rolnitzky L and Rom WN: Survival after surgery in stage IA and IB non-small cell lung cancer. Am J Respir Crit Care Med. 177:516–523. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Zhong GC, Yan B, Sun Y, et al: Clinical efficacy of immunotherapy of dendritic cell and cytokine-induced killer cell combined with chemotherapy for treatment of multiple myeloma. Zhonghua Xue Ye Xue Za Zhi. 33:1000–1003. 2012.(In Chinese).

9 

Zhan HL, Gao X, Pu XY, Li W, Li ZJ, Zhou XF and Qiu JG: A randomized controlled trial of postoperative tumor lysate-pulsed dendritic cells and cytokine-induced killer cells immunotherapy in patients with localized and locally advanced renal cell carcinoma. Chin Med J (Engl). 125:3771–3777. 2012.

10 

Shi SB, Ma TH, Li CH and Tang XY: Effect of maintenance therapy with dendritic cells: cytokine-induced killer cells in patients with advanced non-small cell lung cancer. Tumori. 98:314–319. 2012.PubMed/NCBI

11 

Sargent D, Shi Q, Yothers G, et al; Adjuvant Colon Cancer End-points (ACCENT) Group. Two or three year disease-free survival (DFS) as a primary end-point in stage III adjuvant colon cancer trials with fluoropyrimidines with or without oxaliplatin or irinotecan: data from 12,676 patients from MOSAIC, X-ACT, PETACC-3, C-06, C-07 and C89803. Eur J Cancer. 47:990–996. 2011.

12 

Fidler MJ, Kim AW, Zusag T and Bonomi P: Treatment of locally advanced non-small cell lung cancer. Clin Adv Hematol Oncol. 7:455–464. 479–480. 2009.

13 

Juretic A, Sobat H and Samija M: Combined modality therapy of non-small cell lung cancers. Ann Oncol. 10(Suppl 6): 93–98. 1999. View Article : Google Scholar

14 

Seder CW, Allen MS, Cassivi SD, et al: Stage IIIA non-small cell lung cancer: morbidity and mortality of three distinct multimodality regimens. Ann Thorac Surg. 95:1708–1716. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Carney DN: Lung cancer - time to move on from chemotherapy. N Engl J Med. 346:126–128. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Yuan XK, Zhao XK, Xia YC, Zhu X and Xiao P: Increased circulating immunosuppressive CD14+HLA-DR−/low cells correlate with clinical cancer stage and pathological grade in patients with bladder carcinoma. J Int Med Res. 39:1381–1391. 2011.PubMed/NCBI

17 

Ren J, Di L, Song G, et al: Selections of appropriate regimen of high-dose chemotherapy combined with adoptive cellular therapy with dendritic and cytokine-induced killer cells improved progression-free and overall survival in patients with metastatic breast cancer: reargument of such contentious therapeutic preferences. Clin Transl Oncol. 15:780–788. 2013.

18 

Shi L, Zhou Q, Wu J, Ji M, Li G, Jiang J and Wu C: Efficacy of adjuvant immunotherapy with cytokine-induced killer cells in patients with locally advanced gastric cancer. Cancer Immunol Immunother. 61:2251–2259. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Sangiolo D, Mesiano G, Carnevale-Schianca F, Piacibello W, Aglietta M and Cignetti A: Cytokine induced killer cells as adoptive immunotherapy strategy to augment graft versus tumor after hematopoietic cell transplantation. Expert Opin Biol Ther. 9:831–840. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Zheng YW, Li RM, Zhang XW and Ren XB: Current adoptive immunotherapy in non-small cell lung cancer and potential influence of therapy outcome. Cancer Invest. 31:197–205. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao M, Li H, Li L and Zhang Y: Effects of a gemcitabine plus platinum regimen combined with a dendritic cell-cytokine induced killer immunotherapy on recurrence and survival rate of non-small cell lung cancer patients. Exp Ther Med 7: 1403-1407, 2014.
APA
Zhao, M., Li, H., Li, L., & Zhang, Y. (2014). Effects of a gemcitabine plus platinum regimen combined with a dendritic cell-cytokine induced killer immunotherapy on recurrence and survival rate of non-small cell lung cancer patients. Experimental and Therapeutic Medicine, 7, 1403-1407. https://doi.org/10.3892/etm.2014.1574
MLA
Zhao, M., Li, H., Li, L., Zhang, Y."Effects of a gemcitabine plus platinum regimen combined with a dendritic cell-cytokine induced killer immunotherapy on recurrence and survival rate of non-small cell lung cancer patients". Experimental and Therapeutic Medicine 7.5 (2014): 1403-1407.
Chicago
Zhao, M., Li, H., Li, L., Zhang, Y."Effects of a gemcitabine plus platinum regimen combined with a dendritic cell-cytokine induced killer immunotherapy on recurrence and survival rate of non-small cell lung cancer patients". Experimental and Therapeutic Medicine 7, no. 5 (2014): 1403-1407. https://doi.org/10.3892/etm.2014.1574
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao M, Li H, Li L and Zhang Y: Effects of a gemcitabine plus platinum regimen combined with a dendritic cell-cytokine induced killer immunotherapy on recurrence and survival rate of non-small cell lung cancer patients. Exp Ther Med 7: 1403-1407, 2014.
APA
Zhao, M., Li, H., Li, L., & Zhang, Y. (2014). Effects of a gemcitabine plus platinum regimen combined with a dendritic cell-cytokine induced killer immunotherapy on recurrence and survival rate of non-small cell lung cancer patients. Experimental and Therapeutic Medicine, 7, 1403-1407. https://doi.org/10.3892/etm.2014.1574
MLA
Zhao, M., Li, H., Li, L., Zhang, Y."Effects of a gemcitabine plus platinum regimen combined with a dendritic cell-cytokine induced killer immunotherapy on recurrence and survival rate of non-small cell lung cancer patients". Experimental and Therapeutic Medicine 7.5 (2014): 1403-1407.
Chicago
Zhao, M., Li, H., Li, L., Zhang, Y."Effects of a gemcitabine plus platinum regimen combined with a dendritic cell-cytokine induced killer immunotherapy on recurrence and survival rate of non-small cell lung cancer patients". Experimental and Therapeutic Medicine 7, no. 5 (2014): 1403-1407. https://doi.org/10.3892/etm.2014.1574
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