Effects of metformin on endothelial function in type 2 diabetes

Wu,Songlin; Li,Xiaoyan; Zhang,Hongming

doi:10.3892/etm.2014.1582

May-2014 Volume 7 Issue 5

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May-2014 Volume 7 Issue 5

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Article

Effects of metformin on endothelial function in type 2 diabetes

Authors:
- Songlin Wu
- Xiaoyan Li
- Hongming Zhang
View Affiliations / Copyright

Affiliations: Department of Geriatrics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Cardiology, Jinan Military General Hospital, Jinan, Shandong 250031, P.R. China
Pages: 1349-1353
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Published online on: February 24, 2014

https://doi.org/10.3892/etm.2014.1582
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Abstract

The aim of the present study was to examine the effect of metformin on endothelial function in patients with type 2 diabetes mellitus (T2DM). In total, 93 patients with T2DM and dissatisfactory glycemic control were randomly assigned to the metformin and pioglitazone groups and changes in vascular endothelial function were subsequently observed. Blood sugar levels and the insulin resistance (IR) index of the patients prior to treatment were lower than those following 12 months of treatment. In addition, fasting and postprandial insulin levels and the insulin function index were higher compared with those obtained following 12 months of treatment (P<0.05). Following 12 months of treatment, the body mass index (BMI) in the metformin group was lower than that in the pioglitazone group (P<0.05). Vascular endothelial function had improved in the groups following 12 months of treatment, when compared with the levels prior to treatment (P<0.05). Following 12 months of treatment, endothelial function in the metformin group had improved markedly compared with that in the pioglitazone group (P<0.05). Therefore, the administration of metformin and pioglitazone in patients with T2DM may improve insulin function, reduce the role of IR and improve endothelial function. Metformin is more successful than pioglitazone in reducing BMI and improving endothelial function.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effects of metformin on endothelial function in type 2 diabetes

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