Effect of sodium valproate on the sleep structures of epileptic patients

Zhang,Hui; Li,Yuechun; Li,Xiue; Liu,Guorong; Wang,Baojun; Li,Chunhua

doi:10.3892/etm.2014.1593

May-2014 Volume 7 Issue 5

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May-2014 Volume 7 Issue 5

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Article

Effect of sodium valproate on the sleep structures of epileptic patients

Authors:
- Hui Zhang
- Yuechun Li
- Xiue Li
- Guorong Liu
- Baojun Wang
- Chunhua Li
View Affiliations / Copyright

Affiliations: Department of Neurology, Baotou Central Hospital, Baotou, Inner Mongolia Autonomous Region 014040, P.R. China
Pages: 1227-1232
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Published online on: February 28, 2014

https://doi.org/10.3892/etm.2014.1593
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Abstract

The aims of the present study were to investigate the effect of sodium valproate (VPA) on the sleep structures of epileptic patients and the correlation of these effects with patient weight gain. A total of 60 epileptic patients were divided into three groups: E-AED I (VPA administration for a duration of <3 months), E-AED II (VPA administration for a duration of >3 months) and ECO (without VPA) groups, for polysomnography monitoring. When the E-AED II group was compared with the E-AED I and ECO groups, non-rapid eye movement sleep phase 1 was significantly prolonged (92.10±48.24, 29.50±10.61 and 23.94±13.27 min, respectively; P<0.01), rapid eye movement sleep was significantly shortened (70.82±17.69, 116.99±12.90 and 126.19±35.01 min, respectively; P<0.01), sleep efficiency was significantly reduced (89.39±2.55, 91.98±2.53 and 91.96±3.14%, respectively; P<0.01), the number of times of that the patients awoke was significantly increased (7.25±2.86, 2.55±1.42 and 2.40±1.39, respectively; P<0.01) and the number of REM phases throughout the night was significantly reduced (P<0.01). There were no significant differences for the various sleep parameters between the E-AED I and ECO groups. Therefore, VPA is capable of inducing sleep structure disorders in epileptic patients. In addition, these disorders begin 3 months following the administration of VPA, which indicates that these disorders may be associated with VPA-induced weight gain.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effect of sodium valproate on the sleep structures of epileptic patients

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