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Article

Renal neutrophil gelatinase‑associated lipocalin and kidney injury molecule‑1 expression in children with acute kidney injury and Henoch‑Schönlein purpura nephritis

  • Authors:
    • Yue Du
    • Ling Hou
    • Jinjie Guo
    • Tingting Sun
    • Xiuli Wang
    • Yubin Wu
  • View Affiliations / Copyright

    Affiliations: Department of Pediatric Nephrology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China
  • Pages: 1130-1134
    |
    Published online on: February 28, 2014
       https://doi.org/10.3892/etm.2014.1595
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Abstract

The aim of this study was to investigate the expression of neutrophil gelatinase‑associated lipocalin (NGAL) and kidney injury molecule‑1 (KIM‑1) in the serum, urine and renal tissues of children with acute kidney injury (AKI) and Henoch‑Schönlein purpura nephritis (A‑on‑C). A prospective single‑center evaluation of the serum, urine and renal NGAL and KIM‑1 levels was performed in a cohort of children. Blood and 5‑ml urine samples were collected from each patient for the analysis of NGAL and KIM‑1 levels using an ELISA. In addition, the expression of NGAL and KIM‑1 in the kidney was examined using immunohistochemistry in patients with A‑on‑C and HSPN. The expression of serum cystatin C, β2‑macroglobulin and serum creatinine (SCr), as well as urinary β2‑MG and SCr, in the patients with A‑on‑C was significantly higher than that of HSPN patients, and the expression of NGAL and KIM‑1 in the serum and urine in the A‑on‑C patients was also significantly higher than that of HSPN patients. However, there were no significant differences in the urine protein levels between the two groups. NGAL and KIM‑1 were expressed in renal tubular epithelial cells, and the expression of NGAL and KIM‑1 in the A‑on‑C patients was significantly higher than that in HSPN patients. In addition, the urine NGAL and KIM‑1 levels were negatively correlated with glomerular filtration rate, but there was no significant correlation between the urine NGAL/KIM‑1 and urine protein levels. The changes in serum and urine NGAL and KIM‑1 levels may be applied to the diagnosis of A‑on‑C.
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1 

Xue JL, Daniels F, Star RA, et al: Incidence and mortality of acute renal failure in Medicare beneficiaries, 1992 to 2001. J Am Soc Nephrol. 17:1135–1142. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Liaño F and Pascual J: Epidemiology of acute renal failure: A prospective, multicenter, community-based study. Madrid Acute Renal Failure Study Group. Kidney Int. 50:811–818. 1996.PubMed/NCBI

3 

Pisoni R, Wille KM and Tolwani AJ: The epidemiology of severe acute kidney injury: from BEST to PICARD, in acute kidney injury: new concepts. Nephron Clin Pract. 109:c188–c191. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Vachvanichsanong P, Dissaneewate P, Lim A and McNeil E: Childhood acute renal failure: 22-year experience in a university hospital in southern Thailand. Pediatrics. 118:e786–e791. 2006.PubMed/NCBI

5 

Hui-Stickle S, Brewer ED and Goldstein SL: Pediatric ARF epidemiology at a tertiary care center from 1999 to 2001. Am J Kidney Dis. 45:96–101. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Ronkainen J, Ala-Houhala M, Huttunen NP, Jahnukainen T, Koskimies O, Ormälä T and Nuutinen M: Outcome of Henoch-Schonlein nephritis with nephrotic-range proteinuria. Clin Nephrol. 60:80–84. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Shenoy M, Bradbury MG, Lewis MA and Webb NJ: Outcome of Henoch-Schönlein purpura nephritis treated with long-term immunosuppression. Pediatr Nephrol. 22:1717–1722. 2007.PubMed/NCBI

8 

Coppo R, Andrulli S, Amore A, et al: Prediction of outcome in Henoch-Schönlein Nephritis in children and adults. Am J Kidney Dis. 47:993–1003. 2006.PubMed/NCBI

9 

Supavekin S, Zhang W, Kucherlapati R, et al: Differential gene expression following early renal ischemia/reperfusion. Kidney Int. 63:1714–1724. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Mishra J, Ma Q, Prada A, et al: Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol. 14:2534–2543. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Mishra J, Mori K, Ma Q, et al: Neutrophil gelatinase-associated lipocalin: a novel early urinary biomarker for cisplatin nephrotoxicity. Am J Nephrolol. 24:307–315. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Mishra J, Mori K, Ma Q, et al: Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin. J Am Soc Nephrol. 15:3073–3082. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Devarajan P, Mishra J, Supavekin S, et al: Gene expression in early ischemic renal injury: clues towards pathogenesis, biomarker discovery, and novel therapeutics. Mol Genet Metab. 80:365–376. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Devarajan P: Cellular and molecular derangements in acute tubular necrosis. Curr Opin Pediatr. 17:193–199. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Nguyen MT, Ross GF, Dent CL, et al: Early prediction of acute renal injury using urinary proteomics. Am J Nephrol. 25:318–326. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Mishra J, Ma Q, Kelly C, et al: Kidney NGAL is a novel marker of acute injury following transplantation. Pediatr Nephrol. 21:856–863. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Mishra J, Dent C, Tarabishi R, et al: Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet. 365:1231–1238. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Davide B, Antonio L, Giuseppe C, et al: Neutrophil gelatinase-associated lipocalin (NGAL) and progession of chronic kidney disease. Clin J Am Nephrol. 4:337–344. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Dent CL, Ma Q, Dastrala S, et al: Plasma NGAL predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study. Crit Care. 11:R1272007. View Article : Google Scholar : PubMed/NCBI

20 

Parikh CR, Jani A, Mishra J, et al: Urine NGAL and IL-18 are predictive biomarkers for delayed graft function following kidney transplantation. Am J Transplant. 6:1639–1645. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Trachtman H, Christen E, Cnaan A, et al: Urinary neutrophil gelatinase-associated lipocalcin in D+HUS: a novel marker of renal injury. Pediatr Nophrol. 21:989–994. 2006.PubMed/NCBI

22 

Hirsch R, Dent C, Pfriem H, et al: NGAL is an early predictive biomarker of contrast-induced nephropathy in children. Pediatr Nephrol. 22:2089–2095. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Vaidya VS, Ramirez V, Ichimura T, et al: Urinary kidney injury molecule-1: A sensitive quantitative biomarker for early detection of kidney tubular injury. Am J Physiol Renal Physiol. 290:F517–F529. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Zhang Z, Humphreys BD and Bonventre JV: Shedding of the urinary biomarker kidney injury molecule-1 (KIM-1) is upregulated by MAP kinases and juxtamembrane region. J Am Soc Nephrol. 18:2702–2714. 2007. View Article : Google Scholar : PubMed/NCBI

25 

van Timmeren MM, van den Heuvel MC, Bailly V, et al: Tubular kidney injury molecule-1 (KIM-1) in human renal disease. J Pathol. 212:209–217. 2007.

26 

van Timmeren MM, Bakker SJ, Vaidya VS, et al: Tubular kidney injury molecule-1 in protein overload nephropathy. Am J Physiol Renal Physiol. 291:F456–F464. 2006.PubMed/NCBI

27 

Akcan-Arikan A, Zappitelli M, Loftis LL, et al: Modified RIFLE criteria in critically ill children with acute kidney injury. Kidney Int. 71:1028–1035. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Schwartz GJ, Brion LP and Spitzer A: The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children and adolescents. Pediatr Clin North Am. 34:571–590. 1987.PubMed/NCBI

29 

Clinical practice guideline for acute kidney injury. KDIGO (Kidney Disease: Improving Global Outcome). 2:124–138. 2012.

30 

Davin JC and Weening JJ: Henoch-Schönlein purpura nephritis: an update. Eur J Pediatr. 160:689–695. 2001.

31 

Lau KK, Suzuki H, Novak J and Wyatt RJ: Pathogenesis of Henoch-Schönlein purpura nephritis. Pediatr Nephrol. 25:19–26. 2010.

32 

Pitashny M, Schwartz N, Qing X, et al: Urinary lipocalin-2 is associated with renal disease activity in human lupus nephritis. Arthritis Rheum. 56:1894–1903. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Du Y, Hou L, Guo J, Sun T, Wang X and Wu Y: Renal neutrophil gelatinase‑associated lipocalin and kidney injury molecule‑1 expression in children with acute kidney injury and Henoch‑Schönlein purpura nephritis. Exp Ther Med 7: 1130-1134, 2014.
APA
Du, Y., Hou, L., Guo, J., Sun, T., Wang, X., & Wu, Y. (2014). Renal neutrophil gelatinase‑associated lipocalin and kidney injury molecule‑1 expression in children with acute kidney injury and Henoch‑Schönlein purpura nephritis. Experimental and Therapeutic Medicine, 7, 1130-1134. https://doi.org/10.3892/etm.2014.1595
MLA
Du, Y., Hou, L., Guo, J., Sun, T., Wang, X., Wu, Y."Renal neutrophil gelatinase‑associated lipocalin and kidney injury molecule‑1 expression in children with acute kidney injury and Henoch‑Schönlein purpura nephritis". Experimental and Therapeutic Medicine 7.5 (2014): 1130-1134.
Chicago
Du, Y., Hou, L., Guo, J., Sun, T., Wang, X., Wu, Y."Renal neutrophil gelatinase‑associated lipocalin and kidney injury molecule‑1 expression in children with acute kidney injury and Henoch‑Schönlein purpura nephritis". Experimental and Therapeutic Medicine 7, no. 5 (2014): 1130-1134. https://doi.org/10.3892/etm.2014.1595
Copy and paste a formatted citation
x
Spandidos Publications style
Du Y, Hou L, Guo J, Sun T, Wang X and Wu Y: Renal neutrophil gelatinase‑associated lipocalin and kidney injury molecule‑1 expression in children with acute kidney injury and Henoch‑Schönlein purpura nephritis. Exp Ther Med 7: 1130-1134, 2014.
APA
Du, Y., Hou, L., Guo, J., Sun, T., Wang, X., & Wu, Y. (2014). Renal neutrophil gelatinase‑associated lipocalin and kidney injury molecule‑1 expression in children with acute kidney injury and Henoch‑Schönlein purpura nephritis. Experimental and Therapeutic Medicine, 7, 1130-1134. https://doi.org/10.3892/etm.2014.1595
MLA
Du, Y., Hou, L., Guo, J., Sun, T., Wang, X., Wu, Y."Renal neutrophil gelatinase‑associated lipocalin and kidney injury molecule‑1 expression in children with acute kidney injury and Henoch‑Schönlein purpura nephritis". Experimental and Therapeutic Medicine 7.5 (2014): 1130-1134.
Chicago
Du, Y., Hou, L., Guo, J., Sun, T., Wang, X., Wu, Y."Renal neutrophil gelatinase‑associated lipocalin and kidney injury molecule‑1 expression in children with acute kidney injury and Henoch‑Schönlein purpura nephritis". Experimental and Therapeutic Medicine 7, no. 5 (2014): 1130-1134. https://doi.org/10.3892/etm.2014.1595
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