Expression of ERβ, ERα and Her-2 and distribution of molecular subtypes in Uygur and Han patients with breast cancer

Guo,Liying; Hou,Xueqin; Dilimina,Yilamu; Wang,Bowei

doi:10.3892/etm.2014.1596

Expression of ERβ, ERα and Her-2 and distribution of molecular subtypes in Uygur and Han patients with breast cancer

Authors:
- Liying Guo
- Xueqin Hou
- Yilamu Dilimina
- Bowei Wang
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Affiliations: Department of Breast Cancer, Digestive and Vascular Center, The First Affiliated Hospital of Xinjiang Medical University, Urumchi, Xingjiang 830054, P.R. China, Department of Pathology, The First Affiliated Hospital of Xinjiang Medical University, Urumchi, Xingjiang 830054, P.R. China
Published online on: March 4, 2014 https://doi.org/10.3892/etm.2014.1596
Pages: 1077-1082

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Abstract

The aim of the present study was to investigate the expression levels of estrogen receptor (ER) α and β and human epidermal growth factor receptor-2 (Her-2), as well as the distribution of breast cancer molecular subtypes in Uygur and Han breast cancer patients. Cancer tissues were collected and analyzed from 709 breast cancer patients enrolled between January 2000 and December 2010. The expression levels of ERα, ERβ and Her-2 were determined by immunohistochemistry. The differences in expression and molecular subtype distribution between Uygur and Han patients with breast cancer were analyzed using a Pearson's χ2 test. Statistically significant differences were observed in the expression levels of ERβ, ERα and Her-2 between the Uygur and Han patients with breast cancer (P<0.05). The expression levels of ERβ (++), ERβ (+++) and Her-2 (+++) in Uygur patients were significantly higher, while the expression levels of ERα (+++) in Uygur patients were significantly lower when compared with Han patients. The percentage of luminal A type breast cancer in Uygur patients was significantly lower when compared with the Han patients, whereas the percentages of basal-like and Her-2 overexpression types were significantly higher than those in Han patients (P<0.05). Therefore, expression levels of ERβ, ERα and Her-2, and molecular subtypes of breast cancer were significantly different between the Uygur and Han populations.

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1	Li CI, Malone KE and Daling JR: Differences in breast cancer stage, treatment, and survival by race and ethnicity. Arch Intern Med. 163:49–56. 2003. View Article : Google Scholar : PubMed/NCBI
2	Gao F, Wang J, Liu X, et al: Racial differences in breast cancer survival in Yunnan. Zhong guo yi xue li lun yu shi jian za zi. 1:778–779. 2003.(In Chinese).
3	Newman B, Moorman PG, Millikan R, et al: The Carolina Breast Cancer Study: intergrating population-based epidemiology and molecular biology. Breast Cancer Res Treat. 35:51–60. 1995. View Article : Google Scholar : PubMed/NCBI
4	Hammond ME, Hayes DF, Wolff AC, et al: American society of clinical oncology/college of american pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer. J Oncol Pract. 6:195–197. 2010. View Article : Google Scholar
5	Breast cancer compiling group. Guidelines for HER2 detection in breast cancer, the 2009 version. Chinese Journal of Pathology. 38:836–840. 2009.(In Chinese).
6	Kuiper GG, Enmark E, Pelto-Huikko M, et al: Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA. 93:5925–5930. 1996. View Article : Google Scholar : PubMed/NCBI
7	Dotzlaw H, Leygue E, Watson PH and Murphy LC: Expression of estrogen receptor-beta in human tumors. J Clin Endocrinol Metab. 82:2371–2374. 1997. View Article : Google Scholar : PubMed/NCBI
8	Järvinen TA, Pelto-Huikko M, Holli K and Isola J: Estrogen receptor beta is coexpressed with ERalpha and PR and associated with nodal status, grade, and proliferation rate in breast cancer. Am J Pathol. 156:29–35. 2000.PubMed/NCBI
9	Mann S, Laucirica R, Carlson N, et al: Estrogen receptor beta expression in invasive breast cancer. Hum Pathol. 32:113–118. 2001. View Article : Google Scholar : PubMed/NCBI
10	Fuqua SA, Schiff R, Parra I, et al: Estrogen receptor beta protein in human breast cancer: correlation with clinical tumor parameters. Cancer Res. 63:2434–2439. 2003.
11	Han J, Wang PJ, Tang RY, et al: The expression of estrogen receptor α, β in different breast tissues and its relation with breast cancer. Tongji xue bao. 26:21–24. 2005.(In Chinese).
12	Li Y, Wu MB, Zhao XX, et al: Loss of heterozygosity and cloning of human chromosome 3p24 in esophageal carcinoma. Xinjiang Yi Ke Da Xue Xue Bao. 26:224–226. 2003.(In Chinese).
13	Chen R, Li TF, Wang XL, et al: Clinical epidemiological analysis of cervical carcinoma of 2417 cases in Xinjiang. Zhonghua Zhong Liu Fang Zhi Za Zhi. 15:329–331. 2008.(In Chinese).
14	Elledge RM, Clark GM, Chamness GC and Osborne CK: Tumor biologic factors and breast cancer prognosis among white, Hispanic, and black women in the United State. J Natl Cancer Inst. 86:705–712. 1994. View Article : Google Scholar : PubMed/NCBI
15	Miller BA, Hankey BF and Thomas TL: Impact of sociodemographic factors, hormone receptor status, and tumor grade on ethnic differences in tumor stage and size for breast cancer in US women. Am J Epidemiol. 155:534–545. 2002. View Article : Google Scholar
16	Schwartz LH, Koerner FC, Edgerton SM, et al: pS2 expression and response to hormonal therapy in patients with advanced breast cancer. Cancer Res. 51:624–628. 1991.PubMed/NCBI
17	Al-Abbadi MA, Washington TA, Saleh HA, et al: Differential expression of HER-2/NEU receptor of invasive mammary carcinoma between Caucasian and African American patients in the Detroit metropolitan area. Correlation with overall survival and other prognostic factors. Breast Cancer Res Treat. 97:3–8. 2006. View Article : Google Scholar
18	Yang H, Shi X, Lv X and Li H: The difference in expressions of CD44v5 and HER4 between Uygur and Han with breast invasive duct carcinoma. Zhongguo Lao Nian Xue Za Zhi. 26:589–590. 2006.(In Chinese).
19	Perou CM, Sørlie T, Eisen MB, et al: Molecular portraits of human breast tumours. Nature. 406:747–752. 2000. View Article : Google Scholar : PubMed/NCBI
20	Carey LA, Perou CM, Livasy CA, et al: Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA. 295:2492–2502. 2006. View Article : Google Scholar : PubMed/NCBI