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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Article

Expression of ERβ, ERα and Her-2 and distribution of molecular subtypes in Uygur and Han patients with breast cancer

  • Authors:
    • Liying Guo
    • Xueqin Hou
    • Yilamu Dilimina
    • Bowei Wang
  • View Affiliations / Copyright

    Affiliations: Department of Breast Cancer, Digestive and Vascular Center, The First Affiliated Hospital of Xinjiang Medical University, Urumchi, Xingjiang 830054, P.R. China, Department of Pathology, The First Affiliated Hospital of Xinjiang Medical University, Urumchi, Xingjiang 830054, P.R. China
  • Pages: 1077-1082
    |
    Published online on: March 4, 2014
       https://doi.org/10.3892/etm.2014.1596
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Abstract

The aim of the present study was to investigate the expression levels of estrogen receptor (ER) α and β and human epidermal growth factor receptor-2 (Her-2), as well as the distribution of breast cancer molecular subtypes in Uygur and Han breast cancer patients. Cancer tissues were collected and analyzed from 709 breast cancer patients enrolled between January 2000 and December 2010. The expression levels of ERα, ERβ and Her-2 were determined by immunohistochemistry. The differences in expression and molecular subtype distribution between Uygur and Han patients with breast cancer were analyzed using a Pearson's χ2 test. Statistically significant differences were observed in the expression levels of ERβ, ERα and Her-2 between the Uygur and Han patients with breast cancer (P<0.05). The expression levels of ERβ (++), ERβ (+++) and Her-2 (+++) in Uygur patients were significantly higher, while the expression levels of ERα (+++) in Uygur patients were significantly lower when compared with Han patients. The percentage of luminal A type breast cancer in Uygur patients was significantly lower when compared with the Han patients, whereas the percentages of basal-like and Her-2 overexpression types were significantly higher than those in Han patients (P<0.05). Therefore, expression levels of ERβ, ERα and Her-2, and molecular subtypes of breast cancer were significantly different between the Uygur and Han populations.
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Copy and paste a formatted citation
Spandidos Publications style
Guo L, Hou X, Dilimina Y and Wang B: Expression of ERβ, ERα and Her-2 and distribution of molecular subtypes in Uygur and Han patients with breast cancer. Exp Ther Med 7: 1077-1082, 2014.
APA
Guo, L., Hou, X., Dilimina, Y., & Wang, B. (2014). Expression of ERβ, ERα and Her-2 and distribution of molecular subtypes in Uygur and Han patients with breast cancer. Experimental and Therapeutic Medicine, 7, 1077-1082. https://doi.org/10.3892/etm.2014.1596
MLA
Guo, L., Hou, X., Dilimina, Y., Wang, B."Expression of ERβ, ERα and Her-2 and distribution of molecular subtypes in Uygur and Han patients with breast cancer". Experimental and Therapeutic Medicine 7.5 (2014): 1077-1082.
Chicago
Guo, L., Hou, X., Dilimina, Y., Wang, B."Expression of ERβ, ERα and Her-2 and distribution of molecular subtypes in Uygur and Han patients with breast cancer". Experimental and Therapeutic Medicine 7, no. 5 (2014): 1077-1082. https://doi.org/10.3892/etm.2014.1596
Copy and paste a formatted citation
x
Spandidos Publications style
Guo L, Hou X, Dilimina Y and Wang B: Expression of ERβ, ERα and Her-2 and distribution of molecular subtypes in Uygur and Han patients with breast cancer. Exp Ther Med 7: 1077-1082, 2014.
APA
Guo, L., Hou, X., Dilimina, Y., & Wang, B. (2014). Expression of ERβ, ERα and Her-2 and distribution of molecular subtypes in Uygur and Han patients with breast cancer. Experimental and Therapeutic Medicine, 7, 1077-1082. https://doi.org/10.3892/etm.2014.1596
MLA
Guo, L., Hou, X., Dilimina, Y., Wang, B."Expression of ERβ, ERα and Her-2 and distribution of molecular subtypes in Uygur and Han patients with breast cancer". Experimental and Therapeutic Medicine 7.5 (2014): 1077-1082.
Chicago
Guo, L., Hou, X., Dilimina, Y., Wang, B."Expression of ERβ, ERα and Her-2 and distribution of molecular subtypes in Uygur and Han patients with breast cancer". Experimental and Therapeutic Medicine 7, no. 5 (2014): 1077-1082. https://doi.org/10.3892/etm.2014.1596
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