Relationship between p53 gene codon‑72 polymorphisms and hypertrophic scar formation following caesarean section

Gao,Jianhua; Chen,Ying; Liao,Nong; Zhao,Wei; Zeng,Weisen; Li,Yingtao; Wang,Shaojing; Lu,Feng

doi:10.3892/etm.2014.1605

May-2014 Volume 7 Issue 5

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May-2014 Volume 7 Issue 5

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Article

Relationship between p53 gene codon‑72 polymorphisms and hypertrophic scar formation following caesarean section

Authors:
- Jianhua Gao
- Ying Chen
- Nong Liao
- Wei Zhao
- Weisen Zeng
- Yingtao Li
- Shaojing Wang
- Feng Lu
View Affiliations / Copyright

Affiliations: Department of Plastic and Reconstructive Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Plastic Surgery, The Third Affiliated Hospital of Guangzhou Medical College, Guangzhou, Guangdong 510150, P.R. China, Department of Cell Biology, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical College, Guangzhou, Guangdong 510150, P.R. China
Pages: 1243-1246
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Published online on: March 5, 2014

https://doi.org/10.3892/etm.2014.1605
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Abstract

The aim of the present study was to determine the relationship between p53 gene codon‑72 polymorphisms and hypertrophic scar formation following caesarean section (CS). Blood samples from 260 female patients were collected one week following a CS for the detection of p53 gene polymorphisms using a molecular beacon‑coupled quantitative polymerase chain reaction technique. Patients had follow‑ups for 12‑18 months to observe the scar formation. From these observations, the relationship between the p53 codon‑72 polymorphisms and hypertrophic scar formation occurrence was investigated. Among the patients with the CCC/CCC genotype, nine patients had hypertrophic scars and 46 patients showed normal healing, which is a ratio of 0.19. However, the follow‑up investigations indicated that the presence of a homozygous or heterozygous C‑to‑G alteration at the codon‑72 site in gene p53 resulted in 13 patients with hypertrophic scars and 192 patients with normal healing, which is a ratio of 0.07. Therefore, these results indicate that patients with the CCC/CCC genotype had a higher risk of developing hypertrophic scars compared with that for patients with the CCC/CGC or CGC/CGC genotypes.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Relationship between p53 gene codon‑72 polymorphisms and hypertrophic scar formation following caesarean section

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Abstract

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