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Monoamine neurotransmitters and fibroblast growth factor‑2 in the brains of rats with post‑stroke depression

  • Authors:
    • Xiao‑Wei Ji
    • Chun‑Ling Wu
    • Xing‑Chen Wang
    • Jie Liu
    • Jian‑Zhong Bi
    • Dian‑Yun Wang
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Second Hospital Affiliated to Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250001, P.R. China, Blood Purification Center, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, P.R. China, Department of Neurology, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China, Department of Traditional Chinese Medicine, Dongying People's Hospital, Dongying, Shandong 257091, P.R. China
  • Pages: 159-164
    |
    Published online on: April 8, 2014
       https://doi.org/10.3892/etm.2014.1674
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Abstract

The aim of the present study was to investigate the changes in the levels of serotonin (5‑HT), dopamine (DA), norepinephrine (NE) and fibroblast growth factor‑2 (FGF‑2) in the brains of rats with post‑stroke depression (PSD). A rat model of stroke was established by middle cerebral artery occlusion and the rats were randomly divided into two groups: Control and modification groups. The rats in the modification group had PSD, while the rats in the control group had experienced a stroke only. The PSD model was established by applying chronic mild stress to the individually housed rats. High‑performance liquid chromatography was used to detect the levels of 5‑HT, DA and NE, while western blotting was used to detect the FGF‑2 protein expression levels in the frontal lobe and hippocampus. Quantitative polymerase chain reaction was also used to determine the mRNA expression levels of FGF‑2 in the frontal lobes of the two groups. The levels of 5‑HT, DA and NE in the frontal lobe and hippocampus of the rats in the PSD group were significantly lower than the levels observed in the rats in the stroke group (P<0.01). In addition, protein expression levels of FGF‑2 in the frontal lobe of the rats in the PSD group were significantly lower when compared with the control group rats (P<0.01), however, the protein expression levels of FGF‑2 in the hippocampus did not exhibit a statistically significant difference (P>0.05). The mRNA expression levels of FGF‑2 in the frontal lobe of the rats in the modification group were significantly lower than the levels in the control group rats (P<0.01). Therefore, reduced levels of monoamine neurotransmitters and FGF‑2 expression in the brains of rats with PSD are associated with the incidence of PSD.
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Copy and paste a formatted citation
Spandidos Publications style
Ji XW, Wu CL, Wang XC, Liu J, Bi JZ and Wang DY: Monoamine neurotransmitters and fibroblast growth factor‑2 in the brains of rats with post‑stroke depression. Exp Ther Med 8: 159-164, 2014.
APA
Ji, X., Wu, C., Wang, X., Liu, J., Bi, J., & Wang, D. (2014). Monoamine neurotransmitters and fibroblast growth factor‑2 in the brains of rats with post‑stroke depression. Experimental and Therapeutic Medicine, 8, 159-164. https://doi.org/10.3892/etm.2014.1674
MLA
Ji, X., Wu, C., Wang, X., Liu, J., Bi, J., Wang, D."Monoamine neurotransmitters and fibroblast growth factor‑2 in the brains of rats with post‑stroke depression". Experimental and Therapeutic Medicine 8.1 (2014): 159-164.
Chicago
Ji, X., Wu, C., Wang, X., Liu, J., Bi, J., Wang, D."Monoamine neurotransmitters and fibroblast growth factor‑2 in the brains of rats with post‑stroke depression". Experimental and Therapeutic Medicine 8, no. 1 (2014): 159-164. https://doi.org/10.3892/etm.2014.1674
Copy and paste a formatted citation
x
Spandidos Publications style
Ji XW, Wu CL, Wang XC, Liu J, Bi JZ and Wang DY: Monoamine neurotransmitters and fibroblast growth factor‑2 in the brains of rats with post‑stroke depression. Exp Ther Med 8: 159-164, 2014.
APA
Ji, X., Wu, C., Wang, X., Liu, J., Bi, J., & Wang, D. (2014). Monoamine neurotransmitters and fibroblast growth factor‑2 in the brains of rats with post‑stroke depression. Experimental and Therapeutic Medicine, 8, 159-164. https://doi.org/10.3892/etm.2014.1674
MLA
Ji, X., Wu, C., Wang, X., Liu, J., Bi, J., Wang, D."Monoamine neurotransmitters and fibroblast growth factor‑2 in the brains of rats with post‑stroke depression". Experimental and Therapeutic Medicine 8.1 (2014): 159-164.
Chicago
Ji, X., Wu, C., Wang, X., Liu, J., Bi, J., Wang, D."Monoamine neurotransmitters and fibroblast growth factor‑2 in the brains of rats with post‑stroke depression". Experimental and Therapeutic Medicine 8, no. 1 (2014): 159-164. https://doi.org/10.3892/etm.2014.1674
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