Prediction of antiviral efficacy in patients with chronic hepatitis C by changes in forkhead box protein 3 levels

Chang,Jia‑Bao; Xue,Rong; Zhou,Zhen‑Xian; Feng,Yan‑Hong; Dai,Wei‑Wei; Qiu,Jie; Yang,Yong‑Feng

doi:10.3892/etm.2014.1675

July-2014 Volume 8 Issue 1

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July-2014 Volume 8 Issue 1

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Article

Prediction of antiviral efficacy in patients with chronic hepatitis C by changes in forkhead box protein 3 levels

Authors:
- Jia‑Bao Chang
- Rong Xue
- Zhen‑Xian Zhou
- Yan‑Hong Feng
- Wei‑Wei Dai
- Jie Qiu
- Yong‑Feng Yang
View Affiliations / Copyright

Affiliations: Department of Liver Disease, The Second Affiliated Hospital, Southeast University, Nanjing, Jiangsu 210007, P.R. China
Pages: 165-168
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Published online on: April 8, 2014

https://doi.org/10.3892/etm.2014.1675
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Abstract

The aim of the present study was to investigate the distribution of CD4+CD25+ regulatory T cells (Tregs) in the peripheral blood of patients with chronic hepatitis C; in addition to identifying whether the distribution of CD4+CD25+ Tregs predicts the efficacy of antiviral therapy for HCV. The expression of CD4+CD25+ forkhead box protein (FOXP) 3+ Tregs within a CD4+ T cell population was detected in the peripheral blood obtained from patients with chronic hepatitis C and from healthy control subjects using flow cytometry. The hepatitis C virus (HCV)‑RNA load was measured using quantitative‑fluorescence polymerase chain reaction. CD4+CD25+FOXP3+ Tregs accounted for 14.24±1.33% of the CD4+ T cells in the peripheral blood of patients with chronic hepatitis C, which was higher than that of the healthy control subjects (5.62±1.21%; P<0.001). Furthermore, the frequency of CD4+CD25+FOXP3+ Tregs in CD4+ T cells of the peripheral blood positively correlated with the HCV‑RNA load (r=0.73; P=0.032). Therefore, the results of the present study indicated that the expression of CD4+CD25+FOXP3+ Tregs increased in patients that were chronically infected with HCV and positively correlated with the HCV‑RNA load.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Prediction of antiviral efficacy in patients with chronic hepatitis C by changes in forkhead box protein 3 levels

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