Correlation between sialic acid levels in the synovial fluid and the radiographic severity of knee osteoarthritis

Cui,Zhigang; Liu,Kemin; Wang,Anqing; Liu,Sihai; Wang,Fei; Li,Jianjun

doi:10.3892/etm.2014.1679

July-2014 Volume 8 Issue 1

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July-2014 Volume 8 Issue 1

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Article

Correlation between sialic acid levels in the synovial fluid and the radiographic severity of knee osteoarthritis

Authors:
- Zhigang Cui
- Kemin Liu
- Anqing Wang
- Sihai Liu
- Fei Wang
- Jianjun Li
View Affiliations / Copyright

Affiliations: Rehabilitation College, Capital Medical University, Beijing 100069, P.R. China
Pages: 255-259
|
Published online on: April 14, 2014

https://doi.org/10.3892/etm.2014.1679
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Abstract

Osteoarthritis (OA) is associated with the presence of inflammation. Sialic acid (SA), an acetylated derivative of neuraminic acid, is reported to be a useful biomarker of inflammation. The aim of the present study was to investigate the correlation between SA levels in the serum and synovial fluid (SF) and radiographic severity in patients with knee OA. A total of 234 patients with knee OA were recruited for the study, as well as 20 patients that had suffered a knee injury or fracture (without knee OA) and 160 healthy controls. Radiological grading of OA in the knee was conducted according to the Kellgren‑Lawrence (KL) grading system. SA levels in the serum and SF were measured using Warren's thiobarbituric acid assay. The results demonstrated that knee OA patients exhibited significantly elevated levels of serum SA when compared with the healthy controls, and also significantly elevated levels of SF SA when compared with the knee fracture patients. Higher SA levels in the SF were identified in knee OA patients with KL grade 4 as compared with patients with KL grade 2 or 3. In addition, OA patients of KL grade 3 had significantly higher SA levels in the SF as compared with patients with KL grade 2 (P<0.01). The SA levels in the SF of the knee OA patients positively correlated with the KL grades (r=0.353; P<0.01). However, there was no significant correlation identified between serum SA levels and KL grade. Therefore, SA levels in the SF positively correlated with the radiographic severity of OA, thus, SA levels in the SF may serve as a biomarker for the progression of OA.

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1	Kalai E, Bahlous A, Charni N, Bouzid K, Sahli H, Chelly M, Meddeb M, Zouari B, Abdelmoula J and Sellami S: Increased urinary type II collagen C-telopeptide levels in Tunisian patients with knee osteoarthritis. Clin Lab. 58:209–215. 2012.PubMed/NCBI
2	Xu L, Zhu GB, Wang L, Wang DF and Jiang XR: Synovial fluid omentin-1 levels are inversely correlated with radiographic severity of knee osteoarthritis. J Investig Med. 60:583–586. 2012.PubMed/NCBI
3	Pantsulaia I, Kalichman L and Kobyliansky E: Association between radiographic hand osteoarthritis and RANKL, OPG and inflammatory markers. Osteoarthritis Cartilage. 18:1448–1453. 2010. View Article : Google Scholar : PubMed/NCBI
4	Stannus O, Jones G, Cicuttini F, Parameswaran V, Quinn S, Burgess J and Ding C: Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults. Osteoarthritis Cartilage. 18:1441–1447. 2010.
5	Wolfe F: The C-reactive protein but not erythrocyte sedimentation rate is associated with clinical severity in patients with osteoarthritis of the knee or hip. J Rheumatol. 24:1486–1488. 1997.PubMed/NCBI
6	Yokoyama H, Jensen JS, Jensen T and Deckert T: Serum sialic acid concentration is elevated in IDDM especially in early diabetic nephropathy. J Intern Med. 237:519–523. 1995. View Article : Google Scholar : PubMed/NCBI
7	Pönniö M, Alho H, Nikkari ST, Olsson U, Rydberg U and Sillanaukee P: Serum sialic acid in a random sample of the general population. Clin Chem. 45:1842–1849. 1999.
8	Taniuchi K, Chifu K, Hayashi N, Nakamachi Y, Yamaguchi N, Miyamoto Y, Doi K, Baba S, Uchida Y, Tsukada Y and Sugimori T: A new enzymatic method for the determination of sialic acid in serum and its application for a marker of acute phase reactants. Kobe J Med Sci. 27:91–102. 1981.PubMed/NCBI
9	von Versen-Hoeynck FM, Hubel CA, Gallaher MJ, Gammill HS and Powers RW: Plasma levels of inflammatory markers neopterin, sialic acid, and C-reactive protein in pregnancy and preeclampsia. Am J Hypertens. 22:687–692. 2009.PubMed/NCBI
10	Ozben T: Elevated serum and urine sialic acid levels in renal diseases. Ann Clin Biochem. 28:44–48. 1991. View Article : Google Scholar : PubMed/NCBI
11	Bhide SV, Parekh AJ and Desai MP: Sialic acid levels in serum and cerebrospinal fluid (CSF) in infectious and noninfectious conditions. Biochem Med. 18:99–101. 1977. View Article : Google Scholar : PubMed/NCBI
12	Shamberger RJ: Serum sialic acid in normals and in cancer patients. J Clin Chem Clin Biochem. 22:647–651. 1984.PubMed/NCBI
13	Alturfan AA, Uslu E, Alturfan EE, Hatemi G, Fresko I and Kokoglu E: Increased serum sialic acid levels in primary osteoarthritis and inactive rheumatoid arthritis. Tohoku J Exp Med. 213:241–248. 2007. View Article : Google Scholar : PubMed/NCBI
14	Kellgren JH and Lawrence JS: Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 16:494–502. 1957. View Article : Google Scholar : PubMed/NCBI
15	Warren L: The thiobarbituric acid assay of sialic acids. J Biol Chem. 234:1971–1975. 1959.PubMed/NCBI
16	Felson DT: Clinical practice. Osteoarthritis of the knee. N Engl J Med. 354:841–848. 2006. View Article : Google Scholar : PubMed/NCBI
17	Cooke TD: Immune pathology in polyarticular osteoarthritis. Clin Orthop Relat Res. 213:41–49. 1986.PubMed/NCBI
18	Gobezie R, Kho A, Krastins B, Sarracino DA, Thornhill TS, Chase M, Millett PJ and Lee DM: High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis. Arthritis Res Ther. 9:R362007. View Article : Google Scholar : PubMed/NCBI
19	Chavan MM, Kawle PD and Mehta NG: Increased sialylation and defucosylation of plasma proteins are early events in the acute phase response. Glycobiology. 15:838–848. 2005. View Article : Google Scholar : PubMed/NCBI
20	Browning LM, Krebs JD and Jebb SA: Discrimination ratio analysis of inflammatory markers: implications for the study of inflammation in chronic disease. Metabolism. 53:899–903. 2004. View Article : Google Scholar : PubMed/NCBI
21	Kosakai O: Clinical relevance of sialic acids determination in serum and synovial fluid in orthopaedic disorders. Rinsho Byori. 39:197–207. 1991.(In Japanese).

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Correlation between sialic acid levels in the synovial fluid and the radiographic severity of knee osteoarthritis

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