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Inhibitory effect of rape pollen supercritical CO2 fluid extract against testosterone‑induced benign prostatic hyperplasia in rats

  • Authors:
    • Bi‑Cheng Yang
    • Li‑Li Jin
    • Yi‑Fang Yang
    • Kun Li
    • Dan‑Ming Peng
  • View Affiliations / Copyright

    Affiliations: Department of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, P.R. China, Jiangxi Institute of Traditional Chinese Medicine, Nanchang, Jiangxi 330000, P.R. China
  • Pages: 31-37
    |
    Published online on: April 14, 2014
       https://doi.org/10.3892/etm.2014.1680
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Abstract

Benign prostatic hyperplasia (BPH) can lead to lower urinary tract symptoms. Rape pollen is an apicultural product that is composed of nutritionally valuable and biologically active substances. The aim of the present study was to investigate the protective effect of rape pollen supercritical CO2 fluid extract (SFE‑CO2) in BPH development using a testosterone‑induced BPH rat model. BPH was induced in the experimental groups by daily subcutaneous injections of testosterone for a period of 30 days. Rape pollen SFE‑CO2 was administered daily by oral gavage concurrently with the testosterone injections. Animals were sacrificed at the scheduled termination and the prostates were weighed and subjected to histopathological examination. Testosterone, dihydrotestosterone (DHT), 5α‑reductase and cyclooxygenase‑2 (COX‑2) levels were also measured. BPH‑induced animals exhibited an increase in prostate weight with increased testosterone, DHT, 5α‑reductase and COX‑2 expression levels. However, rape pollen SFE‑CO2 treatment resulted in significant reductions in the prostate index and testosterone, DHT, 5α‑reductase and COX‑2 levels compared with those in BPH‑induced animals. Histopathological examination also demonstrated that rape pollen SFE‑CO2 treatment suppressed testosterone‑induced BPH. These observations indicate that rape pollen SFE‑CO2 inhibits the development of BPH in rats and these effects are closely associated with reductions in DHT, 5α‑reductase and COX‑2 levels. Therefore, the results of the present study clearly indicate that rape pollen SFE‑CO2 extract may be a useful agent in BPH treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Yang BC, Jin LL, Yang YF, Li K and Peng DM: Inhibitory effect of rape pollen supercritical CO2 fluid extract against testosterone‑induced benign prostatic hyperplasia in rats. Exp Ther Med 8: 31-37, 2014.
APA
Yang, B., Jin, L., Yang, Y., Li, K., & Peng, D. (2014). Inhibitory effect of rape pollen supercritical CO2 fluid extract against testosterone‑induced benign prostatic hyperplasia in rats. Experimental and Therapeutic Medicine, 8, 31-37. https://doi.org/10.3892/etm.2014.1680
MLA
Yang, B., Jin, L., Yang, Y., Li, K., Peng, D."Inhibitory effect of rape pollen supercritical CO2 fluid extract against testosterone‑induced benign prostatic hyperplasia in rats". Experimental and Therapeutic Medicine 8.1 (2014): 31-37.
Chicago
Yang, B., Jin, L., Yang, Y., Li, K., Peng, D."Inhibitory effect of rape pollen supercritical CO2 fluid extract against testosterone‑induced benign prostatic hyperplasia in rats". Experimental and Therapeutic Medicine 8, no. 1 (2014): 31-37. https://doi.org/10.3892/etm.2014.1680
Copy and paste a formatted citation
x
Spandidos Publications style
Yang BC, Jin LL, Yang YF, Li K and Peng DM: Inhibitory effect of rape pollen supercritical CO2 fluid extract against testosterone‑induced benign prostatic hyperplasia in rats. Exp Ther Med 8: 31-37, 2014.
APA
Yang, B., Jin, L., Yang, Y., Li, K., & Peng, D. (2014). Inhibitory effect of rape pollen supercritical CO2 fluid extract against testosterone‑induced benign prostatic hyperplasia in rats. Experimental and Therapeutic Medicine, 8, 31-37. https://doi.org/10.3892/etm.2014.1680
MLA
Yang, B., Jin, L., Yang, Y., Li, K., Peng, D."Inhibitory effect of rape pollen supercritical CO2 fluid extract against testosterone‑induced benign prostatic hyperplasia in rats". Experimental and Therapeutic Medicine 8.1 (2014): 31-37.
Chicago
Yang, B., Jin, L., Yang, Y., Li, K., Peng, D."Inhibitory effect of rape pollen supercritical CO2 fluid extract against testosterone‑induced benign prostatic hyperplasia in rats". Experimental and Therapeutic Medicine 8, no. 1 (2014): 31-37. https://doi.org/10.3892/etm.2014.1680
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