MicroRNA‑203 inhibits malignant melanoma cell migration by targeting versican Retraction in /10.3892/etm.2023.12308

Bu,Pingyuan; Yang,Ping

doi:10.3892/etm.2014.1708

MicroRNA‑203 inhibits malignant melanoma cell migration by targeting versican

Retraction in: /10.3892/etm.2023.12308

Authors:
- Pingyuan Bu
- Ping Yang
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Affiliations: Department of Burns, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China
Published online on: May 12, 2014 https://doi.org/10.3892/etm.2014.1708
Pages: 309-315

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Abstract

MicroRNA (miR)‑203 has been demonstrated to function as a suppressor in tumorigenesis. Recently, miR‑203 was reported to play a role in malignant melanoma (MM); however, the detailed function of miR‑203 in MM remains unclear. In the present study, the expression of miR‑203 was shown to be significantly downregulated in MM tissues when compared with normal adjacent tissues. Based on a bioinformatic prediction, versican was further identified as a novel target of miR‑203, and the expression of versican was markedly increased in MM tissues. Inhibition of miR‑203 increased the protein expression of versican, while upregulation of miR‑203 inhibited the protein expression of versican in MM A375 cells. In addition, the upregulation of versican significantly promoted A375 cell migration; however, upregulation of miR‑203 suppressed A375 cell migration. The present study further investigated whether miR‑203 was involved in versican‑mediated A375 cell migration, and the results indicated that upregulation of miR-203 significantly inhibited A375 cell migration, which was impaired by overexpression of versican. These observations indicated that versican functions as a downstream effector in miR‑203‑mediated MM cell migration. Therefore, the results demonstrated that miR‑203 exhibited an inhibitory effect on MM cell migration via directly targeting versican, thus, may become an effective inhibitor for MM metastasis.

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