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Article

Expression of circulating vascular endothelial growth factor‑antagonizing cytokines and vascular stabilizing factors prior to and following bypass surgery in patients with moyamoya disease

  • Authors:
    • Jin He
    • Rong Wang
    • Dong Zhang
    • Yan Zhang
    • Qian Zhang
    • Jizong Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, P.R. China
  • Pages: 302-308
    |
    Published online on: May 14, 2014
       https://doi.org/10.3892/etm.2014.1713
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Abstract

The aim of the present study was to investigate the levels of vascular endothelial growth factor (VEGF)‑antagonizing cytokines and VEGF‑influenced vascular stabilizing cytokines in patients with moyamoya disease (MMD) and the association with postoperative collateral vessel formation. The study population included 53 MMD patients that had undergone indirect bypass surgery and 50 healthy controls. Serum levels of VEGF, thrombospondin‑1 (TSP‑1), TSP‑2, soluble VEGF receptor‑1 (sVEGFR‑1), sVEGFR‑2, endostatin, angiopoietin‑1 (Ang‑1) and Ang‑2 were measured at the baseline (preoperative) and at day seven following surgery. Postoperative collateralization assessment was conducted upon the six‑month follow‑up cerebral angiography. Cytokine levels were compared between patients with good or poor collateral formation. Compared with the healthy controls, MMD patients exhibited lower baseline levels of sVEGFR‑1 (P<0.0001) and sVEGFR‑2 (P<0.0001), but higher VEGF expression (P<0.0001). Ang‑1 and Ang‑2 levels did not exhibit any difference between the two groups. On day seven following surgery, MMD patients exhibited an almost unchanged sVEGFR‑1 and sVEGFR‑2 expression level, but upregulated expression of VEGF (P<0.0001), Ang‑1 (P<0.0001) and TSP‑2 (P<0.0001). The six‑month follow‑up angiographies revealed that 21 patients (45.65%) that had undergone the same surgical procedure achieved good collateralization. Patients with good collateral formation appeared to have lower sVEGFR‑1 and sVEGFR‑2 levels prior to (P=0.029 and P=0.045, respectively) and at day seven (P=0.044 and P=0.047, respectively) following bypass surgery when compared with the patients with worse collateralization. Therefore, sVEGFR‑1 and sVEGFR‑2 may play a role in the pathogenesis of MMD. Lower levels of sVEGFR‑1 and sVEGFR‑2 indicated better postoperative collateralization in the six months following indirect bypass surgery. However, Ang‑1 and Ang‑2 may not be specifically involved in the course of MMD.
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1 

Horev L, Lees MM, Anteby I, et al: Oculoectodermal syndrome with coarctation of the aorta and moyamoya disease: expanding the phenotype to include vascular anomalies. Am J Med Genet A. 155:577–581. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Yamashita M, Oka K and Tanaka K: Histopathology of the brain vascular network in moyamoya disease. Stroke. 14:50–58. 1983. View Article : Google Scholar : PubMed/NCBI

3 

Takebayashi S, Matsuo K and Kaneko M: Ultrastructural studies of cerebral arteries and collateral vessels in moyamoya disease. Stroke. 15:728–732. 1984. View Article : Google Scholar : PubMed/NCBI

4 

Kuroda S and Houkin K: Moyamoya disease: current concepts and future perspectives. Lancet Neurol. 7:1056–1066. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Vajkoczy P: Moyamoya disease: collateralization is everything. Cerebrovasc Dis. 28:2582009. View Article : Google Scholar : PubMed/NCBI

6 

Sun Y, Jin K, Xie L, et al: VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J Clin Invest. 111:1843–1851. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Yang HT, Yan Z, Abraham JA and Terjung RL: VEGF121- and bFGF-induced increase in collateral blood flow requires normal nitric oxide production. Am J Physiol Heart Circ Physiol. 280:H1097–H1104. 2001.PubMed/NCBI

8 

Sakamoto S, Kiura Y, Yamasaki F, et al: Expression of vascular endothelial growth factor in dura mater of patients with moyamoya disease. Neurosurg Rev. 31:77–81. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Rafat N, Beck GCh, Peña-Tapia PG, Schmiedek P and Vajkoczy P: Increased levels of circulating endothelial progenitor cells in patients with moyamoya disease. Stroke. 40:432–438. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Kang HS, Kim JH, Phi JH, et al: Plasma matrix metalloproteinases, cytokines and angiogenic factors in moyamoya disease. J Neurol Neurosurg Psychiatry. 81:673–678. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Park YS, Jeon YJ, Kim HS, et al: The role of VEGF and KDR polymorphisms in moyamoya disease and collateral revascularization. PLoS One. 7:e471582012. View Article : Google Scholar : PubMed/NCBI

12 

Suzuki J and Kodama N: Moyamoya disease - a review. Stroke. 14:104–109. 1983. View Article : Google Scholar

13 

Smith ER and Scott RM: Surgical management of moyamoya syndrome. Skull Base. 15:15–26. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Kuroda S and Houkin K: Bypass surgery for moyamoya disease: concept and essence of sugical techniques. Neurol Med Chir (Tokyo). 52:287–294. 2012.PubMed/NCBI

15 

Matsushima T, Fukui M, Kitamura K, et al: Encephalo-duro-arterio-synangiosis in children with moyamoya disease. Acta Neurochir (Wien). 104:96–102. 1990. View Article : Google Scholar : PubMed/NCBI

16 

Saito N and Imai H: Insights on the revascularization mechanism for treatment of moyamoya disease based on the histopathologic concept of angiogenesis and arteriogenesis. World Neurosurg. 75:204–205. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Yancopoulos GD, Davis S, Gale NW, et al: Vascular-specific growth factors and blood vessel formation. Nature. 407:242–248. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Carmeliet P: Mechanisms of angiogenesis and arteriogenesis. Nat Med. 6:389–395. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Ferrara N, Gerber HP and LeCouter J: The biology of VEGF and its receptors. Nat Med. 9:669–676. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Zeng H, Dvorak HF and Mukhopadhyay D: Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) receptor-1 downmodulates VPF/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through phosphatidylinositol 3-kinase-dependent pathways. J Biol Chem. 276:26969–26979. 2001. View Article : Google Scholar

21 

Roberts DM, Kearney JB, Johnson JH, et al: The vascular endothelial growth factor (VEGF) receptor Flt-1 (VEGFR-1) modulates Flk-1 (VEGFR-2) signaling during blood vessel formation. Am J Pathol. 164:1531–1535. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Yoshimoto T, Houkin K, Takahashi A and Abe H: Angiogenic factors in moyamoya disease. Stroke. 27:2160–2165. 1996. View Article : Google Scholar : PubMed/NCBI

23 

Olfert IM, Howlett RA, Wagner PD and Breen EC: Myocyte vascular endothelial growth factor is required for exercise-induced skeletal muscle angiogenesis. Am J Physiol Regul Integr Comp Physiol. 299:R1059–R1067. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Lloyd PG, Prior BM, Li H, Yang HT and Terjung RL: VEGF receptor antagonism blocks arteriogenesis, but only partially inhibits angiogenesis, in skeletal muscle of exercise-trained rats. Am J Physiol Heart Circ Physiol. 288:H759–H768. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Kendall RL and Thomas KA: Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proc Natl Acad Sci USA. 90:10705–10709. 1993. View Article : Google Scholar : PubMed/NCBI

26 

Jacobi J, Tam BY, Wu G, et al: Adenoviral gene transfer with soluble vascular endothelial growth factor receptors impairs angiogenesis and perfusion in a murine model of hindlimb ischemia. Circulation. 110:2424–2429. 2004. View Article : Google Scholar

27 

Ferrara N and Davis-Smyth T: The biology of vascular endothelial growth factor. Endocr Rev. 18:4–25. 1997. View Article : Google Scholar

28 

Ito TK, Ishii G, Saito S, et al: Degradation of soluble VEGF receptor-1 by MMP-7 allows VEGF access to endothelial cells. Blood. 113:2363–2369. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Ebos JM, Bocci G, Man S, et al: A naturally occurring soluble form of vascular endothelial growth factor receptor 2 detected in mouse and human plasma. Mol Cancer Res. 2:315–326. 2004.PubMed/NCBI

30 

Lorquet S, Berndt S, Blacher S, et al: Soluble forms of VEGF receptor-1 and -2 promote vascular maturation via mural cell recruitment. FASEB J. 24:3782–3795. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Liu X, Zhang D, Shuo W, et al: Long term outcome after conservative and surgical treatment of haemorrhagic moyamoya disease. J Neurol Neurosurg Psychiatry. 84:258–265. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Dixelius J, Cross MJ, Matsumoto T and Claesson-Welsh L: Endostatin action and intracellular signaling: beta-catenin as a potential target? Cancer Lett. 196:1–12. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Lawler PR and Lawler J: Molecular basis for the regulation of angiogenesis by thrombospondin-1 and -2. Cold Spring Harb Perspect Med. 2:a0066272012. View Article : Google Scholar : PubMed/NCBI

34 

Zacharek A, Chen J, Cui X, et al: Angiopoietin1/Tie2 and VEGF/Flk1 induced by MSC treatment amplifies angiogenesis and vascular stabilization after stroke. J Cereb Blood Flow Met. 27:1684–1691. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Hanahan D: Signaling vascular morphogenesis and maintenance. Science. 277:48–50. 1997. View Article : Google Scholar : PubMed/NCBI

36 

Holash J, Wiegand SJ and Yancopoulos GD: New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene. 18:5356–5362. 1999. View Article : Google Scholar : PubMed/NCBI

37 

Nakamura M, Imai H, Konno K, et al: Experimental investigation of encephalomyosynangiosis using gyrencephalic brain of the miniature pig: histopathological evaluation of dynamic reconstruction of vessels for functional anastomosis. J Neurosurg Pediatr. 3:488–495. 2009. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
He J, Wang R, Zhang D, Zhang Y, Zhang Q and Zhao J: Expression of circulating vascular endothelial growth factor‑antagonizing cytokines and vascular stabilizing factors prior to and following bypass surgery in patients with moyamoya disease. Exp Ther Med 8: 302-308, 2014.
APA
He, J., Wang, R., Zhang, D., Zhang, Y., Zhang, Q., & Zhao, J. (2014). Expression of circulating vascular endothelial growth factor‑antagonizing cytokines and vascular stabilizing factors prior to and following bypass surgery in patients with moyamoya disease. Experimental and Therapeutic Medicine, 8, 302-308. https://doi.org/10.3892/etm.2014.1713
MLA
He, J., Wang, R., Zhang, D., Zhang, Y., Zhang, Q., Zhao, J."Expression of circulating vascular endothelial growth factor‑antagonizing cytokines and vascular stabilizing factors prior to and following bypass surgery in patients with moyamoya disease". Experimental and Therapeutic Medicine 8.1 (2014): 302-308.
Chicago
He, J., Wang, R., Zhang, D., Zhang, Y., Zhang, Q., Zhao, J."Expression of circulating vascular endothelial growth factor‑antagonizing cytokines and vascular stabilizing factors prior to and following bypass surgery in patients with moyamoya disease". Experimental and Therapeutic Medicine 8, no. 1 (2014): 302-308. https://doi.org/10.3892/etm.2014.1713
Copy and paste a formatted citation
x
Spandidos Publications style
He J, Wang R, Zhang D, Zhang Y, Zhang Q and Zhao J: Expression of circulating vascular endothelial growth factor‑antagonizing cytokines and vascular stabilizing factors prior to and following bypass surgery in patients with moyamoya disease. Exp Ther Med 8: 302-308, 2014.
APA
He, J., Wang, R., Zhang, D., Zhang, Y., Zhang, Q., & Zhao, J. (2014). Expression of circulating vascular endothelial growth factor‑antagonizing cytokines and vascular stabilizing factors prior to and following bypass surgery in patients with moyamoya disease. Experimental and Therapeutic Medicine, 8, 302-308. https://doi.org/10.3892/etm.2014.1713
MLA
He, J., Wang, R., Zhang, D., Zhang, Y., Zhang, Q., Zhao, J."Expression of circulating vascular endothelial growth factor‑antagonizing cytokines and vascular stabilizing factors prior to and following bypass surgery in patients with moyamoya disease". Experimental and Therapeutic Medicine 8.1 (2014): 302-308.
Chicago
He, J., Wang, R., Zhang, D., Zhang, Y., Zhang, Q., Zhao, J."Expression of circulating vascular endothelial growth factor‑antagonizing cytokines and vascular stabilizing factors prior to and following bypass surgery in patients with moyamoya disease". Experimental and Therapeutic Medicine 8, no. 1 (2014): 302-308. https://doi.org/10.3892/etm.2014.1713
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