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Article

Atorvastatin increases lipopolysaccharide‑induced expression of tumour necrosis factor‑α‑induced protein 8‑like 2 in RAW264.7 cells

  • Authors:
    • Ming‑wei Liu
    • Mei‑xian Su
    • Wei Zhang
    • Li Wang
    • Chuan‑yun Qian
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China, Surgica Intensive Care Unit, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650106, P.R. China
  • Pages: 219-228
    |
    Published online on: May 19, 2014
       https://doi.org/10.3892/etm.2014.1722
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Abstract

RAW264.7 cells are one of the major sources of productive inflammatory biomediators, including tumour necrosis factor‑α (TNF‑α) and interleukin (IL)‑6. TNF‑α‑induced protein 8‑like 2 (TIPE2) is an essential negative regulator of Toll‑like and T‑cell receptors, and the selective expression in the immune system prevents hyper‑responsiveness and maintains immune homeostasis. The aim of the present study was to investigate whether atorvastatin upregulates the expression of TIPE2 and further regulates the inflammatory response and oxidation emergency response in RAW264.7 cells. RAW264.7 cells were incubated in Dulbecco's modified Eagle's medium containing lipopolysaccharide (LPS) in the presence or absence of atorvastatin. Following incubation, the medium was collected and the levels of TNF‑α and IL‑6 were measured using an enzyme‑linked immunosorbent assay. The cells were harvested, and the mRNA and protein expression levels of TIPE2, macrophage migration inhibitory factor (MIF), IκB and nuclear factor (NF‑κB)‑κB were analysed using quantitative polymerase chain reaction and western blotting analysis, respectively, the expression of NOS, COX-2 and HO-1 protein were essayed by western blotting analysis, NO and ROS activities were determined. The results revealed that LPS increased the mRNA and protein expression levels of TIPE2, MIF and NF‑κB, as well as the production of IL-6 and TNF‑α, in a dose and time dependent manner in RAW264.7 cells. Meanwhile, LPS enhanced the expression of NOS and COX-2 protein, blocked HO-1 protein expression, increased NO and PGE2 production and ROS activity in a dose dependent manner in RAW264.7 cells. Atorvastatin significantly increased LPS induced expression of TIPE2, downregulated the expression of NOS, COX-2, MIF and NF‑κB and the production of PGE2, NO, IL-6 and TNF‑α in a time and dose dependent manner, and increased HO-1 protein expression, reduced ROS production in a dose dependent manner. The observations indicated that atorvastatin upregulated LPS induced expression of TIPE2 and consequently inhibited MIF, NF‑κB, NOS and COX-2 expression and the production of NO, PGE2, TNF‑α and IL‑6, increased HO-1 expression, and inhibited ROS activity in cultured RAW264.7 cells.
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1 

Wynn J, Cornell TT, Wong HR, Shanley TP and Wheeler DS: The host response to sepsis and developmental impact. Pediatrics. 125:1031–1041. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Unuma K, Aki T, Funakoshi T, Yoshida K and Uemura K: Cobalt protoporphyrin accelerates TFEB activation and lysosome reformation during LPS-induced septic insults in the rat heart. PLoS One. 8:e565262013. View Article : Google Scholar : PubMed/NCBI

3 

Juskewitch JE, Prasad S, Salas CF and Huskins WC: Reliability of the identification of the systemic inflammatory response syndrome in critically ill infants and children. Pediatr Crit Care Med. 13:e55–e57. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Walley KR, Lukacs NW, Standiford TJ, Strieter RM and Kunkel SL: Balance of inflammatory cytokines related to severity and mortality of murine sepsis. Infect Immun. 64:4733–4738. 1996.PubMed/NCBI

5 

Cinel I and Opal SM: Molecular biology of inflammation and sepsis: a primer. Crit Care Med. 37:291–304. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Woodward MJ, de Boer J, Heidorn S, Hubank M, Kioussis D, Williams O and Brady HJ: TNFAIP8 is an essential gene for the regulation of glucocorticoid-mediated apoptosis of thymocytes. Cell Death Differ. 17:316–323. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Wang Z, Fayngerts S, Wang P, et al: TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection. Proc Natl Acad Sci USA. 109:15413–15418. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Freundt EC, Bidere N and Lenardo MJ: A different TIPE of immune homeostasis. Cell. 133:401–402. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Antonopoulos AS, Margaritis M, Lee R, Channon K and Antoniades C: Statins as anti-inflammatory agents in atherogenesis: molecular mechanisms and lessons from the recent clinical trials. Curr Pharm Des. 18:1519–1530. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Truwit JD: Statins: a role in infected critically ill patients? Crit Care. 15:1452011. View Article : Google Scholar : PubMed/NCBI

11 

Rubinson DA, Dillon CP, Kwiatkowski AV, et al: A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet. 33:401–406. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Wu L, Gokden N and Mayeux PR: Evidence for the role of reactive nitrogen species in polymicrobial sepsis-induced renal peritubular capillary dysfunction and tubular injury. J Am Soc Nephrol. 18:1807–1815. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Dombrovskiy VY, Martin AA, Sunderram J and Paz HL: Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med. 35:1244–1250. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Vigil KJ, Adachi JA and Chemaly RF: Viral pneumonias in immunocompromised adult hosts. J Intensive Care Med. 25:307–326. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Hlava N, Niemann CU, Gropper MA and Melcher ML: Postoperative infectious complications of abdominal solid organ transplantation. J Intensive Care Med. 24:3–17. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Zhao J, Yang X, Auh SL, Kim KD, Tang H and Fu YX: Do adaptive immune cells suppress or activate innate immunity? Trends Immunol. 30:8–12. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Kim KD, Zhao J, Auh S, Yang X, Du P, Tang H and Fu YX: Adaptive immune cells temper initial innate responses. Nat Med. 13:1248–1252. 2007. View Article : Google Scholar : PubMed/NCBI

18 

López-Rincón G, Pereira-Suárez AL, Del Toro-Arreola S, et al: Lipopolysaccharide induces the expression of an autocrine prolactin loop enhancing inflammatory response in monocytes. J Inflamm (Lond). 10:242013.PubMed/NCBI

19 

Jeong IK, Oh da H, Park SJ, et al: Inhibition of NF-κB prevents high glucose-induced proliferation and plasminogen activator inhibitor-1 expression in vascular smooth muscle cells. Exp Mol Med. 43:684–692. 2011.

20 

Lin CC, Shih CH, Yang YL, et al: Thrombin induces inducible nitric oxide synthase expression via the MAPK, MSK1, and NF-κB signaling pathways in alveolar macrophages. Eur J Pharmacol. 672:180–187. 2011.PubMed/NCBI

21 

Zhang LJ, Liu X, Gafken PR, Kioussi C and Leid M: A chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) complex represses expression of the gene encoding tumor necrosis factor alpha-induced protein 8 (TNFAIP8). J Biol Chem. 284:6156–6168. 2009. View Article : Google Scholar

22 

Sun H, Gong S, Carmody RJ, et al: TIPE2, a novel negative regulator of innate and adaptive immunity that maintains immune homeostasis. Cell. 133:415–426. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Laliberté B, Wilson AM, Nafisi H, et al: TNFAIP8: a new effector for Galpha(i) coupling to reduce cell death and induce cell transformation. J Cell Physiol. 225:865–874. 2010.PubMed/NCBI

24 

Antosz H and Choroszyńska D: Negative regulation of Toll-like receptor signalling. Postepy Hig Med Dosw (Online). 67:339–350. 2013.(In Polish).

25 

Zhang X, Wang J, Fan C, et al: Crystal structure of TIPE2 provides insights into immune homeostasis. Nat Struct Mol Biol. 16:89–90. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Li D, Song L, Fan Y, et al: Down-regulation of TIPE2 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus. Clin Immunol. 133:422–427. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Zhang Y, Zeng X, Chen S, et al: Characterization, epitope identification and mechanisms of the anti-septic capacity of monoclonal antibodies against macrophage migration inhibitory factor. Int Immunopharmacol. 11:1333–1340. 2011. View Article : Google Scholar

28 

Healy ZR, Liu H, Holtzclaw WD and Talalay P: Inactivation of tautomerase activity of macrophage migration inhibitory factor by sulforaphane: a potential biomarker for anti-inflammatory intervention. Cancer Epidemiol Biomarkers Prev. 20:1516–1523. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Donnelly LE and Rogers DF: Novel targets and drugs in inflammatory lung disease. Curr Opin Pharmacol. 8:219–221. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Tu YP, Chuang SJ, Chen SC, et al: Simvastatin induces the expression of hemeoxygenase-1 against ischemia-reperfusion injury on the testes in rats. Toxicol Lett. 207:242–250. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Park JS, Jung JS, Jeong YH, et al: Antioxidant mechanism of isoflavone metabolites in hydrogen peroxide-stimulated rat primary astrocytes: critical role of heme oxygenase-1 and NQO1 expression. J Neurochem. 119:909–919. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Nassar NN, Li G, Strat AL and Abdel-Rahman AA: Enhanced hemeoxygenase activity in the rostral ventrolateral medulla mediates exaggerated hemin-evoked hypotension in the spontaneously hypertensive rat. J Pharmacol Exp Ther. 339:267–274. 2011. View Article : Google Scholar

33 

Kagami S, Kanari H, Suto A, et al: HMG-CoA reductase inhibitor simvastatin inhibits proinflammatory cytokine production from murine mast cells. Int Arch Allergy Immunol. 146(Suppl 1): 61–66. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Trezzi M, Blackstone EH, Sun ZY, et al: Statin therapy is associated with fewer infections after cardiac operations. Ann Thorac Surg. 95:892–900. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Chello M, Anselmi A, Spadaccio C, et al: Simvastatin increases neutrophil apoptosis and reduces inflammatory reaction after coronary surgery. Ann Thorac Surg. 83:1374–1380. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Chello M, Mastroroberto P, Patti G, D’Ambrosio A, Morichetti MC, Di Sciascio G and Covino E: Simvastatin attenuates leucocyte-endothelial interactions after coronary revascularisation with cardiopulmonary bypass. Heart. 89:538–543. 2003. View Article : Google Scholar

37 

Chaudhry MZ, Wang JH, Blankson S and Redmond HP: Statin (cerivastatin) protects mice against sepsis related death via reduced proinflammatory cytokines and enhanced bacterial clearance. Surg Infect (Larchmt). 9:183–194. 2008. View Article : Google Scholar

38 

Fraunberger P, Gröne E, Gröne HJ and Walli AK: Simvastatin reduces endotoxin induced nuclear factor kappaB activation and mortality in guinea pigs despite lowering circulating low density lipoprotein cholesterol. Shock. 32:159–163. 2009. View Article : Google Scholar

39 

Lin H, Xiao Y, Chen G, et al: HMG CoA reductase inhibitor simvastatin suppresses Toll like receptor 2 ligand induced activation of nuclear factor kappa B by preventing RhoA activation in monocytes from rheumatoid arthritis patients. Rheumatol Int. 31:1451–1458. 2011. View Article : Google Scholar

40 

Meijvis SC, van de Garde EM, Rijkers GT and Bos WJ: Treatment with anti inflammatory drugs in community acquired pneumonia. J Intern Med. 272:25–35. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Fogerty MD, Efron D, Morandi A, Guy JS, Abumrad NN and Barbul A: Effect of preinjury statin use on mortality and septic shock in elderly burn patients. J Trauma. 69:99–103. 2010. View Article : Google Scholar : PubMed/NCBI

42 

González CM, Luna AH, Morales MP, Sanchez JA, Guzman CO and Granillo GF: Statin anti-inflammatory therapy in septic patients. Critical Care. 12(Suppl5): P26–P35. 2008.

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Copy and paste a formatted citation
Spandidos Publications style
Liu Mw, Su Mx, Zhang W, Wang L and Qian Cy: Atorvastatin increases lipopolysaccharide‑induced expression of tumour necrosis factor‑α‑induced protein 8‑like 2 in RAW264.7 cells. Exp Ther Med 8: 219-228, 2014.
APA
Liu, M., Su, M., Zhang, W., Wang, L., & Qian, C. (2014). Atorvastatin increases lipopolysaccharide‑induced expression of tumour necrosis factor‑α‑induced protein 8‑like 2 in RAW264.7 cells. Experimental and Therapeutic Medicine, 8, 219-228. https://doi.org/10.3892/etm.2014.1722
MLA
Liu, M., Su, M., Zhang, W., Wang, L., Qian, C."Atorvastatin increases lipopolysaccharide‑induced expression of tumour necrosis factor‑α‑induced protein 8‑like 2 in RAW264.7 cells". Experimental and Therapeutic Medicine 8.1 (2014): 219-228.
Chicago
Liu, M., Su, M., Zhang, W., Wang, L., Qian, C."Atorvastatin increases lipopolysaccharide‑induced expression of tumour necrosis factor‑α‑induced protein 8‑like 2 in RAW264.7 cells". Experimental and Therapeutic Medicine 8, no. 1 (2014): 219-228. https://doi.org/10.3892/etm.2014.1722
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Mw, Su Mx, Zhang W, Wang L and Qian Cy: Atorvastatin increases lipopolysaccharide‑induced expression of tumour necrosis factor‑α‑induced protein 8‑like 2 in RAW264.7 cells. Exp Ther Med 8: 219-228, 2014.
APA
Liu, M., Su, M., Zhang, W., Wang, L., & Qian, C. (2014). Atorvastatin increases lipopolysaccharide‑induced expression of tumour necrosis factor‑α‑induced protein 8‑like 2 in RAW264.7 cells. Experimental and Therapeutic Medicine, 8, 219-228. https://doi.org/10.3892/etm.2014.1722
MLA
Liu, M., Su, M., Zhang, W., Wang, L., Qian, C."Atorvastatin increases lipopolysaccharide‑induced expression of tumour necrosis factor‑α‑induced protein 8‑like 2 in RAW264.7 cells". Experimental and Therapeutic Medicine 8.1 (2014): 219-228.
Chicago
Liu, M., Su, M., Zhang, W., Wang, L., Qian, C."Atorvastatin increases lipopolysaccharide‑induced expression of tumour necrosis factor‑α‑induced protein 8‑like 2 in RAW264.7 cells". Experimental and Therapeutic Medicine 8, no. 1 (2014): 219-228. https://doi.org/10.3892/etm.2014.1722
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