Evaluation of fatty liver fibrosis in rabbits using real-time shear wave elastography

Lu,Yongping; Wei,Jia; Tang,Yueyue; Yuan,Yuan; Huang,Yanling; Zhang,Yong; Li,Yunyan

doi:10.3892/etm.2014.1749

Evaluation of fatty liver fibrosis in rabbits using real-time shear wave elastography

Authors:
- Yongping Lu
- Jia Wei
- Yueyue Tang
- Yuan Yuan
- Yanling Huang
- Yong Zhang
- Yunyan Li
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Affiliations: Department of Ultrasound, The Fourth Affiliated Hospital of Kunming Medical University, The Second People's Hospital of Yunnan Province, Kunming, Yunnan 650021, P.R. China, The Liver Disease Center, The Fourth Affiliated Hospital of Kunming Medical University, The Second People's Hospital of Yunnan Province, Kunming, Yunnan 650021, P.R. China
Published online on: May 29, 2014 https://doi.org/10.3892/etm.2014.1749
Pages: 355-362

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Abstract

The aim of the present study was to detect the elastic modulus (stiffness) of the livers of rabbits with non‑alcoholic and alcoholic fatty liver disease using real‑time shear wave elastography (SWE), and to investigate the fibrosis development process in the formation of fatty liver. The stiffness of the fatty livers in rabbit models prepared via feeding with alcohol or a high‑fat diet were measured using a real‑time SWE ultrasound system and a 4-15-MHz linear array probe, and the liver stiffness was compared with the pathological staging of the disease. The stiffness of the liver was positively correlated with the degree of pathological change in fatty liver disease (P<0.01). The stiffness of the liver in the alcoholic fatty liver group was higher compared with that in the non‑alcoholic fatty liver and control groups, and the stiffness in the non‑alcoholic fatty liver group was higher than that in the control group (P<0.01). Real‑time SWE objectively identified the trend in the changing stiffness of the liver and noninvasively detected the development of fibrosis in the progression of non‑alcoholic and alcoholic fatty liver disease.

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