Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
August-2014 Volume 8 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2014 Volume 8 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Analysis of growth factors in serum and induced sputum from patients with asthma

  • Authors:
    • Hui Zou
    • Qiu‑Hong Fang
    • Ying‑Min Ma
    • Xue‑Yan Wang
  • View Affiliations / Copyright

    Affiliations: Department of Allergy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China, Department of Pulmonary and Intensive Care Unit, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China
  • Pages: 573-578
    |
    Published online on: June 4, 2014
       https://doi.org/10.3892/etm.2014.1759
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), the AA and BB isoforms of platelet‑derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) are involved in the pathogenesis of airway inflammation in asthma. In the present study, the associations between asthmatic phenotypes and the expression levels of these mediators in induced sputum and serum were investigated. A total of 62 asthmatic patients were divided into eosinophilic or neutrophilic phenotypes by cytological classification of the induced sputum. In addition, patients were classified according to lung function (FEV1/FVC >70% or FEV1/FVC <70%) and asthma severity (mild, moderate or severe). The concentrations of EGF, bFGF, PDGF‑AA, PDGF‑BB and VEGF in the serum and induced sputum were measured using sandwich enzyme immunoassays. VEGF levels in the serum and induced sputum were higher in patients with an eosinophilic phenotype compared with those with a neutrophilic phenotype. In addition, VEGF expression was higher in patients with an FEV1/FVC value of <70% as compared with patients with an FEV1/FVC value of >70%. Furthermore, the levels of VEGF were higher in patients with severe asthma compared with the patients with mild and moderate asthma. There were no statistically significant differences observed with regard to EGF, bFGF, PDGF‑AA and PDGF‑BB levels among the various phenotypes. Therefore, the observations of the present study indicated that increased VEGF expression in the serum and induced sputum of patients may be associated with eosinophilic airway inflammation, severe airflow limitation and the severity of asthma.
View Figures
View References

1 

Wenzel SE: Asthma: defining of the persistent adult phenotypes. Lancet. 368:804–813. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Green RH, Brightling CE and Bradding P: The reclassification of asthma based on subphenotypes. Curr Opin Allergy Clin Immunol. 7:43–50. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Fahy JV: Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies. Proc Am Thorac Soc. 6:256–259. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Puddicombe SM, Polosa R, Richter A, et al: The involvement of the epidermal growth factor receptor in epithelial repair in asthma. FASEB J. 14:1362–1374. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Polosa R, Puddicombe SM, Krishna MT, et al: Expression of c-erbB receptors and ligands in the bronchial epithelium of asthmatic subjects. J Allergy Clin Immunol. 109:75–81. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Munakata M, Nasuhara Y, Sato A, et al: Expression of epidermal growth factor and epidermal growth factor receptor immunoreactivity in the asthmatic human airway. Am J Respir Crit Care Med. 157:1907–1912. 1998. View Article : Google Scholar : PubMed/NCBI

7 

Nasuhara Y, Munakata M, Sato A, et al: Mechanisms of epidermal growth factor-induces contraction of guinea pig airways. Eur J Pharmacol. 296:161–168. 1996. View Article : Google Scholar : PubMed/NCBI

8 

Patel P, Itoh H, Lederis K, et al: Contraction of guinea pig trachea by epidermal growth factor-urogastrone. Can J Physiol Pharmacol. 66:1308–1312. 1988. View Article : Google Scholar : PubMed/NCBI

9 

Ingram JL and Bonner JC: EGF and PDGF receptor tyrosine kinases as therapeutic targets for chronic lung diseases. Curr Mol Med. 6:409–421. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Redington AE, Roche WR, Madden J, et al: Basic fibroblast growth factor in asthma: measurement in bronchoalveolar lavage fluid basally and following allergen challenge. J Allergy Clin Immunol. 107:384–387. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Gomułka K and Liebhart J: Vascular endothelial growth factor - structure, function and role in airways inflammation and the clinical course of asthma. Pneumonol Alergol Pol. 77:549–553. 2009.(In Polish).

12 

Respiratory diseases branch of Chinese Medical Association. Guidelines for the prevention and treatment of bronchial asthma. Zhonghua Jie He He Hu Xi Za Zhi. 31:177–185. 2008.(In Chinese).

13 

Respiratory diseases branch of Chinese Medical Association. Guidelines on the diagnosis and treatment of cough. Chinese Zhonghua Jie He He Hu Xi Za Zhi. 32:407–413. 2009.(In Chinese).

14 

Horiuchi T and Weller PF: Expression of vascular endothelial growth factor by human eosinophils: upregulation by granulocyte macrophage colony-stimulating factor and interleukin-5. Am J Respir Cell Mol Biol. 17:70–77. 1997. View Article : Google Scholar

15 

Mitsuyama H, Matsuyama W, Iwakawa J, et al: Increased serum vascular endothelial growth factor level in Churg-Strauss syndrome. Chest. 129:407–411. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Lee SY, Kwon S, Kim KH, et al: Expression of vascular endothelial growth factor and hypoxia-inducible factor in the airway of asthmatic patients. Ann Allergy Asthma Immunol. 97:794–799. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Asai K, Kanazawa H, Kamoi H, et al: Increased levels of vascular endothelial growth factor in induced sputum in asthmatic patients. Clin Exp Allergy. 33:595–599. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Yoo Y, Choi IS, Byeon JH, et al: Relationships of methacholine and adenosine monophosphate responsiveness with serum vascular endothelial growth factor in children with asthma. Ann Allergy Asthma Immunol. 104:36–41. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Abdel-Rahman AM, el-Sahrigy SA and Bakr SI: A comparative study of two angiogenic factors: vascular endothelial growth factor and angiogenin in induced sputum from asthmatic children in acute attack. Chest. 129:266–271. 2006. View Article : Google Scholar

20 

Busse W, Banks-Schlegel S, Noel P, et al; NHLBI Working Group. Future research directions in asthma: an NHLBI Working Group report. Am J Respir Crit Care Med. 170:683–690. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Lee CG, Link H, Baluk P, et al: Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat Med. 10:1095–1103. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Kanazawa H, Hirata K and Yoshikawa J: Role of endogenous nitric oxide in exercise-induced airway narrowing in patients with bronchial asthma. J Allergy Clin Immunol. 106:1081–1087. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Salvato G: Quantitative and morphological analysis of the vascular bed in bronchial biopsy specimens from asthmatic and non-asthmatic subjects. Thorax. 56:902–906. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Vrugt B, Wilson S, Bron A, et al: Bronchial angiogenesis in severe glucocorticoid-dependent asthma. Eur Respir J. 15:1014–1021. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Kanazawa H and Yoshikawa J: Effect of beclomethasone dipropionate on basic fibroblast growth factor levels in induced sputum samples from asthmatic patients. Ann Allergy Asthma Immunol. 95:546–550. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zou H, Fang QH, Ma YM and Wang XY: Analysis of growth factors in serum and induced sputum from patients with asthma. Exp Ther Med 8: 573-578, 2014.
APA
Zou, H., Fang, Q., Ma, Y., & Wang, X. (2014). Analysis of growth factors in serum and induced sputum from patients with asthma. Experimental and Therapeutic Medicine, 8, 573-578. https://doi.org/10.3892/etm.2014.1759
MLA
Zou, H., Fang, Q., Ma, Y., Wang, X."Analysis of growth factors in serum and induced sputum from patients with asthma". Experimental and Therapeutic Medicine 8.2 (2014): 573-578.
Chicago
Zou, H., Fang, Q., Ma, Y., Wang, X."Analysis of growth factors in serum and induced sputum from patients with asthma". Experimental and Therapeutic Medicine 8, no. 2 (2014): 573-578. https://doi.org/10.3892/etm.2014.1759
Copy and paste a formatted citation
x
Spandidos Publications style
Zou H, Fang QH, Ma YM and Wang XY: Analysis of growth factors in serum and induced sputum from patients with asthma. Exp Ther Med 8: 573-578, 2014.
APA
Zou, H., Fang, Q., Ma, Y., & Wang, X. (2014). Analysis of growth factors in serum and induced sputum from patients with asthma. Experimental and Therapeutic Medicine, 8, 573-578. https://doi.org/10.3892/etm.2014.1759
MLA
Zou, H., Fang, Q., Ma, Y., Wang, X."Analysis of growth factors in serum and induced sputum from patients with asthma". Experimental and Therapeutic Medicine 8.2 (2014): 573-578.
Chicago
Zou, H., Fang, Q., Ma, Y., Wang, X."Analysis of growth factors in serum and induced sputum from patients with asthma". Experimental and Therapeutic Medicine 8, no. 2 (2014): 573-578. https://doi.org/10.3892/etm.2014.1759
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team