BCL11A gene DNA methylation contributes to the risk of type 2 diabetes in males

  • Authors:
    • Linlin Tang
    • Lingyan Wang
    • Huadan Ye
    • Xuting Xu
    • Qingxiao  Hong
    • Hongwei Wang
    • Leiting Xu
    • Shizhong Bu
    • Lina Zhang
    • Jia Cheng
    • Panpan Liu
    • Meng Ye
    • Yifeng Mai
    • Shiwei Duan
  • View Affiliations

  • Published online on: June 12, 2014     https://doi.org/10.3892/etm.2014.1783
  • Pages: 459-463
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Abstract

BCL11A is a critical modulator involved in hemoglobin switching. Recent studies have established an association between BCL11A gene polymorphisms and a risk of type 2 diabetes (T2D). The aim of the present study was to assess the correlation between BCL11A DNA methylation and T2D. A total of 48 T2D cases and 48 age‑ and gender‑matched controls were recruited to evaluate BCL11A methylation using bisulfite pyrosequencing technology. Although no significant association was observed in BCL11A methylation between T2D patients and healthy controls (P=0.322), breakdown analysis by gender identified a significant association between BCL11A methylation and T2D in males (P=0.018). Notably, there was also a significant female‑specific association between the mean BCL11A DNA methylation and triglyceride (TG) concentration (r=‑0.34; P=0.019). The results indicated that BCL11A methylation contributed to the risk of T2D in males. In addition, BCL11A methylation may have an effect on the development of T2D by influencing TG metabolism. Thus, gender difference may provide new information to aid the understanding of T2D pathogenesis.
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August-2014
Volume 8 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Tang L, Wang L, Ye H, Xu X, Hong Q, Wang H, Xu L, Bu S, Zhang L, Cheng J, Cheng J, et al: BCL11A gene DNA methylation contributes to the risk of type 2 diabetes in males. Exp Ther Med 8: 459-463, 2014
APA
Tang, L., Wang, L., Ye, H., Xu, X., Hong, Q., Wang, H. ... Duan, S. (2014). BCL11A gene DNA methylation contributes to the risk of type 2 diabetes in males. Experimental and Therapeutic Medicine, 8, 459-463. https://doi.org/10.3892/etm.2014.1783
MLA
Tang, L., Wang, L., Ye, H., Xu, X., Hong, Q., Wang, H., Xu, L., Bu, S., Zhang, L., Cheng, J., Liu, P., Ye, M., Mai, Y., Duan, S."BCL11A gene DNA methylation contributes to the risk of type 2 diabetes in males". Experimental and Therapeutic Medicine 8.2 (2014): 459-463.
Chicago
Tang, L., Wang, L., Ye, H., Xu, X., Hong, Q., Wang, H., Xu, L., Bu, S., Zhang, L., Cheng, J., Liu, P., Ye, M., Mai, Y., Duan, S."BCL11A gene DNA methylation contributes to the risk of type 2 diabetes in males". Experimental and Therapeutic Medicine 8, no. 2 (2014): 459-463. https://doi.org/10.3892/etm.2014.1783