ALK-positive diffuse large B-cell lymphoma of the duodenum: A case report and review of the literature

Xing,Xiaoming; Lin,Dongliang; Ran,Wenwen; Liu,Huamin

doi:10.3892/etm.2014.1786

August-2014 Volume 8 Issue 2

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August-2014 Volume 8 Issue 2

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Case Report

ALK-positive diffuse large B-cell lymphoma of the duodenum: A case report and review of the literature

Authors:
- Xiaoming Xing
- Dongliang Lin
- Wenwen Ran
- Huamin Liu
View Affiliations / Copyright

Affiliations: Department of Pathology, The Affiliated Hospital of Qingdao University Medical College, Qingdao, Shandong 266003, P.R. China, Department of Oncology, The Affiliated Hospital of Qingdao University Medical College, Qingdao, Shandong 266003, P.R. China
Pages: 409-412
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Published online on: June 16, 2014

https://doi.org/10.3892/etm.2014.1786
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Abstract

Anaplastic lymphoma kinase (ALK)‑positive diffuse large B‑cell lymphoma (ALK+ DLBCL) is characterized by the presence of immunoblastic or plasmablastic cells with a strong ALK protein expression that is frequently associated with t(2;17)(p23;q23). The present study reports a case of ALK+ DLBCL in a 26‑year‑old male with a duodenal mass. Histologically, the neoplastic cells demonstrated prominent plasmablastic differentiation with abundant amphophilic cytoplasma and central nucleoli. Paraffin immunohistochemistry revealed: an exclusively cytoplasmic granular expression of ALK; CD138, immunoglobulin A (IgA) and CD79α positivity; and focal expression of multiple myeloma oncogene 1 (Mum‑1), CD30 and epithelial membrane antigen (EMA). However, the immunohistochemical staining was negative for CD3, CD38 and CD20. Fluorescence in situ hybridization (FISH) analysis using an ALK break‑apart probe revealed the presence of ALK gene rearrangements in the patient. To the best of our knowledge, the current case represents the first example of primary extranodal ALK+ DLBCL presenting as a duodenal mass.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

ALK-positive diffuse large B-cell lymphoma of the duodenum: A case report and review of the literature

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