Marked improvement of anti‑N‑methyl‑D‑aspartate receptor encephalitis by large‑dose methylprednisolone and plasmapheresis therapy combined with 18F‑fluorodeoxyglucose positron emission tomography imaging: A case report

Chen,Bo; Wang,Yiqi; Geng,Yu; Huang,Yuehong; Guo,Shunyuan; Mao,Xiawa

doi:10.3892/etm.2014.1849

October 2014 Volume 8 Issue 4

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October 2014 Volume 8 Issue 4

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Case Report

Marked improvement of anti‑N‑methyl‑D‑aspartate receptor encephalitis by large‑dose methylprednisolone and plasmapheresis therapy combined with 18F‑fluorodeoxyglucose positron emission tomography imaging: A case report

Authors:
- Bo Chen
- Yiqi Wang
- Yu Geng
- Yuehong Huang
- Shunyuan Guo
- Xiawa Mao
View Affiliations / Copyright

Affiliations: Department of Neurology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, P.R. China, Department of Urology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, P.R. China
Pages: 1167-1169
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Published online on: July 16, 2014

https://doi.org/10.3892/etm.2014.1849
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Abstract

Anti‑N‑methyl‑D‑aspartate receptor (anti‑NMDAR) encephalitis, a recently defined and frequently misdiagnosed disease characterized by psychiatric symptoms, seizures, movement disorders and autonomic dysfunction, has been observed predominantly in young females with ovarian teratoma. Conventional imaging techniques, including computed tomography (CT) and magnetic resonance imaging (MRI), are often ineffective for diagnosis of the disease. If diagnosed early, the initiation of immunotherapy and removal of the tumor (if present) may result in recovery. The current study presents the case of a 38‑year‑old female with classic clinical symptoms of anti‑NMDAR encephalitis. The MRI brain scan results were unremarkable, cerebral spinal fluid (CSF) biochemistry indicated non‑specific lymphocytic pleocytosis and the CSF microbiology studies were negative. 18F‑fluorodeoxyglucose positron emission tomography (18F‑FDG PET) imaging revealed significant generalized asymmetric hypometabolism. The patient demonstrated marked recovery following treatment with a high dose of corticosteroids and plasmapheresis. Accordingly, the follow‑up 18F‑FDG PET imaging revealed significant improvement.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Marked improvement of anti‑N‑methyl‑D‑aspartate receptor encephalitis by large‑dose methylprednisolone and plasmapheresis therapy combined with 18F‑fluorodeoxyglucose positron emission tomography imaging: A case report

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Abstract

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