Graft versus host disease following liver transplantation: A case report

  • Authors:
    • Changsong Zhang
    • Guangshun Yang
    • Yang Ling
    • Guihua Chen
    • Tianbao Zhou
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  • Published online on: July 17, 2014     https://doi.org/10.3892/etm.2014.1850
  • Pages: 1164-1166
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Abstract

Graft versus host disease (GVHD) is an uncommon complication following liver transplantation. In the present case report, a 53‑year‑old male hepatitis B virus carrier was diagnosed with primary liver cancer with post‑hepatitis cirrhosis. Preoperative cytomegalovirus (CMV), Epstein‑Barr virus, coxsackievirus, herpes simplex virus and autoimmune antibody series were negative. Preoperative human leukocyte antigen type was also negative. Following classic orthotropic liver transplantation, postoperative treatment included immunosuppression therapy, infection protection, anti‑human immunodeficiency virus therapy and CMV infection protection therapy. Chemotherapy was initiated at day 16 following surgery. At day 26 following the transplantation, the patient developed a fever of unknown cause, and a scattered red rash was observed behind the left ear and on the neck. The patient presented with a fever of unknown cause, rash, symptoms of the digestive tract, leukocytopenia and pancytopenia. A diagnosis of GVHD was confirmed following a skin biopsy. Symptomatic therapies, including antivirals, anti‑anaphylaxis drugs and steroids were administered. However, the patient succumbed to infection, acute respiratory distress syndrome and multiple organ failure at day 46 following surgery. Therefore, an effective therapeutic strategy for the treatment of GVHD following liver transplantation is yet to be established, and further research is required prior to such a regimen being developed.
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October 2014
Volume 8 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhang C, Yang G, Ling Y, Chen G and Zhou T: Graft versus host disease following liver transplantation: A case report. Exp Ther Med 8: 1164-1166, 2014
APA
Zhang, C., Yang, G., Ling, Y., Chen, G., & Zhou, T. (2014). Graft versus host disease following liver transplantation: A case report. Experimental and Therapeutic Medicine, 8, 1164-1166. https://doi.org/10.3892/etm.2014.1850
MLA
Zhang, C., Yang, G., Ling, Y., Chen, G., Zhou, T."Graft versus host disease following liver transplantation: A case report". Experimental and Therapeutic Medicine 8.4 (2014): 1164-1166.
Chicago
Zhang, C., Yang, G., Ling, Y., Chen, G., Zhou, T."Graft versus host disease following liver transplantation: A case report". Experimental and Therapeutic Medicine 8, no. 4 (2014): 1164-1166. https://doi.org/10.3892/etm.2014.1850