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Article

Regulatory effect of microRNA‑135a on the Th1/Th2 imbalance in a murine model of allergic rhinitis

  • Authors:
    • Yanyun Luo
    • Yuqin Deng
    • Zezhang Tao
    • Shiming Chen
    • Bokui Xiao
    • Jie Ren
    • Zhe Chen
    • Jibo Han
    • Yonggang Kong
    • Yu Xu
    • Minjie Deng
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology ‑ Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
  • Pages: 1105-1110
    |
    Published online on: July 21, 2014
       https://doi.org/10.3892/etm.2014.1855
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Abstract

Allergic rhinitis (AR) is primarily caused by a T helper cell (Th)1/Th2 imbalance. In a murine AR model of a previous study, the serum ovalbumin (OVA)‑sIgE concentration was high, whereas microRNA (miR)‑135a was lowly expressed in the nasal mucosa. The abnormal expression pattern of miR‑135a coincided with highly expressed endogenous factors, including GATA binding protein (GATA)‑3 and interleukin (IL)‑4, and lowly expressed factors, including T‑box expressed in T cells (T‑bet) and interferon (IFN)‑γ. We hypothesized that miR‑135a may play an important role in immune regulation in AR mice. In the present study, AR was induced by OVA in the mice. Two groups of the AR mice were treated with a miR‑135a mimic and a mimic control, respectively. The serum and nasal mucosa were collected for analysis. Following miR‑135a application, the serum OVA‑sIgE concentration was significantly reduced. In the nasal mucosa, the expression levels of miR‑135a were higher, the mRNA and protein expression levels of GATA‑3 and IL‑4 were lower, and the expression levels of T‑bet and IFN‑γ were higher. The miR‑135a corrected the Th1/Th2 imbalance in the AR mice. Findings of this study may provide a basis for novel genetic treatments in addressing allergic diseases.
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1 

Tournoy KG, Hove C, Grooten J, Moerloose K, Brusselle GG and Joos GF: Animal models of allergen-induced tolerance in asthma: are T-regulatory-1 cells (Tr-1) the solution for T-helper-2 cells (Th-2) in asthma? Clin Exp Allergy. 36:8–20. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Yamamoto K, Kawamura I, Tominaga T, et al: Listeriolysin O, a cytolysin derived from Listeria monocytogenes, inhibits generation of ovalbumin-specific Th2 immune response by skewing maturation of antigen-specific T cells into Th1 cells. Clin Exp Immunol. 142:268–274. 2005. View Article : Google Scholar

3 

Obihara CC, Kimpen JL and Beyers N: The potential of Mycobacterium to protect against allergy and asthma. Curr Allergy Asthma Rep. 7:223–230. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Yong J, Chen GQ, Huang B and Wu S: Correlation between the ratio of T-bet/GATA-3 and the levels of IL-4 and IFN-γ in patients with allergic asthma. Mol Med Rep. 4:663–666. 2011.

5 

Park HJ, Lee CM, Jung ID, et al: Quercetin regulates Th1/Th2 balance in a murine model of asthma. Int Immunopharmacol. 9:261–267. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Kim HY, Pichavant M, Matangkasombut P, et al: The development of airway hyperreactivity in T-bet-deficient mice requires CD1d-restricted NKT cells. J Immunol. 182:3252–3261. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Barnes PJ: Role of GATA-3 in allergic diseases. Curr Mol Med. 8:330–334. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Yagi R, Zhu J and Paul WE: An updated view on transcription factor GATA3-mediated regulation of Th1 and Th2 cell differentiation. Int Immunol. 23:415–420. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Naito T, Tanaka H, Naoe Y and Taniuchi I: Transcriptional control of T-cell development. Int Immunol. 23:661–668. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Paul WE: What determines Th2 differentiation, in vitro and in vivo? Immunol Cell Biol. 88:236–239. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Zhu J: Transcriptional regulation of Th2 cell differentiation. Immunol Cell Biol. 88:244–249. 2010. View Article : Google Scholar

12 

Ho IC, Tai TS and Pai SY: GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9:125–135. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Wang SY, Yang M, Xu XP, et al: Intranasal delivery of T-bet modulates the profile of helper T cell immune responses in experimental asthma. J Investig Allergol Clin Immunol. 18:357–365. 2008.PubMed/NCBI

14 

Choi JR, Lee CM, Jung ID, et al: Apigenin protects ovalbumin-induced asthma through the regulation of GATA-3 gene. Int Immunopharmacol. 9:918–924. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Maneechotesuwan K, Yao X, Ito K, et al: Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic disease. PLoS Med. 6:e10000762009. View Article : Google Scholar : PubMed/NCBI

16 

Asirvatham AJ, Gregorie CJ, Hu Z, Magner WJ and Tomasi TB: MicroRNA targets in immune genes and the Dicer/Argonaute and ARE machinery components. Mol Immunol. 45:1995–2006. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Bartel DP: MicroRNAs: target recognition and regulatory functions. Cell. 136:215–233. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Xiao C and Rajewsky K: MicroRNA control in the immune system: basic principles. Cell. 136:26–36. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Lu LF and Liston A: MicroRNA in the immune system, microRNA as an immune system. Immunology. 127:291–298. 2009. View Article : Google Scholar : PubMed/NCBI

20 

O’Connell RM, Rao DS, Chaudhuri AA and Baltimore D: Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol. 10:111–122. 2010.PubMed/NCBI

21 

Lu TX, Hartner J, Lim EJ, et al: MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity. J Immunol. 187:3362–3373. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Chen RF, Huang HC, Ou CY, et al: MicroRNA-21 expression in neonatal blood associated with antenatal immunoglobulin E production and development of allergic rhinitis. Clin Exp Allergy. 40:1482–1490. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Mattes J, Collison A, Plank M, Phipps S and Foster PS: Antagonism of microRNA-126 suppresses the effector function of TH2 cells and the development of allergic airways disease. Proc Natl Acad Sci USA. 106:18704–18709. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Chiba Y, Tanabe M, Goto K, Sakai H and Misawa M: Down-regulation of miR-133a contributes to up-regulation of Rhoa in bronchial smooth muscle cells. Am J Respir Crit Care Med. 180:713–719. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Chiba Y and Misawa M: MicroRNAs and their therapeutic potential for human diseases: miR-133a and bronchial smooth muscle hyperresponsiveness in asthma. J Pharmacol Sci. 114:264–268. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Collison A, Mattes J, Plank M and Foster PS: Inhibition of house dust mite-induced allergic airways disease by antagonism of microRNA-145 is comparable to glucocorticoid treatment. J Allergy Clin Immunol. 128:160–167. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Taganov KD, Boldin MP, Chang KJ and Baltimore D: NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA. 103:12481–12486. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Xiao C, Calado DP, Galler G, et al: MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell. 131:146–159. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Faraoni I, Antonetti FR, Cardone J and Bonmassar E: miR-155 gene: a typical multifunctional microRNA. Biochim Biophys Acta. 1792:497–505. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Costinean S, Zanesi N, Pekarsky Y, et al: Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice. Proc Natl Acad Sci USA. 103:7024–7029. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Wang P, Hou J, Lin L, et al: Inducible microRNA-155 feedback promotes type I IFN signaling in antiviral innate immunity by targeting suppressor of cytokine signaling 1. J Immunol. 185:6226–6233. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Lu LF, Thai TH, Calado DP, et al: Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity. 30:80–91. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Evel-Kabler K, Song XT, Aldrich M, Huang XF and Chen SY: SOCS1 restricts dendritic cells’ ability to break self tolerance and induce antitumor immunity by regulating IL-12 production and signaling. J Clin Invest. 116:90–100. 2006.

34 

Rodriguez A, Vigorito E, Clare S, et al: Requirement of bic/microRNA-155 for normal immune function. Science. 316:608–611. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Harada M, Nakashima K, Hirota T, et al: Functional polymorphism in the suppressor of cytokine signaling 1 gene associated with adult asthma. Am J Respir Cell Mol Biol. 36:491–496. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Yoshimura A, Naka T and Kubo M: SOCS proteins, cytokine signaling and immune regulation. Nat Rev Immunol. 7:454–465. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Banerjee A, Schambach F, DeJong CS, Hammond SM and Reiner SL: Micro-RNA-155 inhibits IFN-gamma signaling in CD4+ T cells. Eur J Immunol. 40:225–231. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Li QJ, Chau J, Ebert PJ, et al: MiR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell. 129:147–161. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Maes T, Tournoy KG and Joos GF: Gene therapy for allergic airway diseases. Curr Allergy Asthma Rep. 11:163–172. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Luo YY, Deng YQ and Tao ZZ: Expression of specific microRNA-135a in nasal mucosa of allergic rhinitis mice. Mil Med J S Chin. 26:102–105. 2012.(In Chinese).

41 

Chakir H, Wang H, Lefebvre DE, Webb J and Scott FW: T-bet/GATA-3 ratio as a measure of the Th1/Th2 cytokine profile in mixed cell populations: predominant role of GATA-3. J Immunol Methods. 278:157–169. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Luo Y, Deng Y, Tao Z, Chen S, Xiao B, Ren J, Chen Z, Han J, Kong Y, Xu Y, Xu Y, et al: Regulatory effect of microRNA‑135a on the Th1/Th2 imbalance in a murine model of allergic rhinitis. Exp Ther Med 8: 1105-1110, 2014.
APA
Luo, Y., Deng, Y., Tao, Z., Chen, S., Xiao, B., Ren, J. ... Deng, M. (2014). Regulatory effect of microRNA‑135a on the Th1/Th2 imbalance in a murine model of allergic rhinitis. Experimental and Therapeutic Medicine, 8, 1105-1110. https://doi.org/10.3892/etm.2014.1855
MLA
Luo, Y., Deng, Y., Tao, Z., Chen, S., Xiao, B., Ren, J., Chen, Z., Han, J., Kong, Y., Xu, Y., Deng, M."Regulatory effect of microRNA‑135a on the Th1/Th2 imbalance in a murine model of allergic rhinitis". Experimental and Therapeutic Medicine 8.4 (2014): 1105-1110.
Chicago
Luo, Y., Deng, Y., Tao, Z., Chen, S., Xiao, B., Ren, J., Chen, Z., Han, J., Kong, Y., Xu, Y., Deng, M."Regulatory effect of microRNA‑135a on the Th1/Th2 imbalance in a murine model of allergic rhinitis". Experimental and Therapeutic Medicine 8, no. 4 (2014): 1105-1110. https://doi.org/10.3892/etm.2014.1855
Copy and paste a formatted citation
x
Spandidos Publications style
Luo Y, Deng Y, Tao Z, Chen S, Xiao B, Ren J, Chen Z, Han J, Kong Y, Xu Y, Xu Y, et al: Regulatory effect of microRNA‑135a on the Th1/Th2 imbalance in a murine model of allergic rhinitis. Exp Ther Med 8: 1105-1110, 2014.
APA
Luo, Y., Deng, Y., Tao, Z., Chen, S., Xiao, B., Ren, J. ... Deng, M. (2014). Regulatory effect of microRNA‑135a on the Th1/Th2 imbalance in a murine model of allergic rhinitis. Experimental and Therapeutic Medicine, 8, 1105-1110. https://doi.org/10.3892/etm.2014.1855
MLA
Luo, Y., Deng, Y., Tao, Z., Chen, S., Xiao, B., Ren, J., Chen, Z., Han, J., Kong, Y., Xu, Y., Deng, M."Regulatory effect of microRNA‑135a on the Th1/Th2 imbalance in a murine model of allergic rhinitis". Experimental and Therapeutic Medicine 8.4 (2014): 1105-1110.
Chicago
Luo, Y., Deng, Y., Tao, Z., Chen, S., Xiao, B., Ren, J., Chen, Z., Han, J., Kong, Y., Xu, Y., Deng, M."Regulatory effect of microRNA‑135a on the Th1/Th2 imbalance in a murine model of allergic rhinitis". Experimental and Therapeutic Medicine 8, no. 4 (2014): 1105-1110. https://doi.org/10.3892/etm.2014.1855
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