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Article

Pollen extract in association with vitamins provides early pain relief in patients affected by chronic prostatitis/chronic pelvic pain syndrome

  • Authors:
    • Tommaso Cai
    • Florian M.E. Wagenlehner
    • Lorenzo Giuseppe Luciani
    • Daniele Tiscione
    • Gianni Malossini
    • Paolo Verze
    • Vincenzo Mirone
    • Riccardo Bartoletti
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Santa Chiara Regional Hospital, Trento, Italy, Clinic and Polyclinic for Urology, Child Urology and Andrology, University Hospital of Giessen und Marburg, Justus‑Liebig University, Giessen, Germany, Department of Urology, University Federico II, Naples, Italy, Department of Urology, University of Florence, Florence, Italy
  • Pages: 1032-1038
    |
    Published online on: July 24, 2014
       https://doi.org/10.3892/etm.2014.1861
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Abstract

The therapeutic efficacy for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is currently unsatisfactory. The aim of the present study was to assess the safety and efficacy of pollen extract in association with vitamins (DEPROX 500®) in males with CP/CPPS. All patients with a diagnosis of CP/CPPS attending the same urologic centre between March and October 2012 were enrolled in this randomised controlled phase III study. Participants were randomised to receive oral capsules of DEPROX 500® (two capsules every 24 h) or ibuprofen (600 mg, one tablet three times a day) for four weeks. The National Institutes of Health Chronic Prostatitis Symptom Index (NIH‑CPSI), International Prostate Symptom Score and Quality of Well‑Being (QoL) questionnaires were used. In the intention‑to‑treat analysis, 87 males (25 class IIIa and 62 class IIIb) with a mean age of 33.6±5.9 years were randomly allocated to the DEPROX 500® (n=41) or ibuprofen (n=46) treatment groups. At the follow‑up examination (following one month of treatment), in the DEPROX 500® group, 31/41 patients (75.6%) reported an improvement in quality of life, defined as a reduction of the NIH‑CPSI total score by ≥25%, compared with 19/46 (41.3%) in the control group (P=0.002). The greater improvement in the DEPROX 500® group compared with the ibuprofen group was statistically significant (treatment difference in the NIH‑CPSI pain domain, ‑2.14±0.51, P<0.001; QoL scores, P=0.002). All patients were negative at the Meares‑Stamey test evaluation. Adverse events were less frequent in the DEPROX 500® group than in the ibuprofen group. The DEPROX 500® treatment significantly improved total symptoms, pain and quality of life compared with ibuprofen in patients with CP/CPPS, without severe side‑effects.
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Copy and paste a formatted citation
Spandidos Publications style
Cai T, Wagenlehner FM, Luciani LG, Tiscione D, Malossini G, Verze P, Mirone V and Bartoletti R: Pollen extract in association with vitamins provides early pain relief in patients affected by chronic prostatitis/chronic pelvic pain syndrome. Exp Ther Med 8: 1032-1038, 2014.
APA
Cai, T., Wagenlehner, F.M., Luciani, L.G., Tiscione, D., Malossini, G., Verze, P. ... Bartoletti, R. (2014). Pollen extract in association with vitamins provides early pain relief in patients affected by chronic prostatitis/chronic pelvic pain syndrome. Experimental and Therapeutic Medicine, 8, 1032-1038. https://doi.org/10.3892/etm.2014.1861
MLA
Cai, T., Wagenlehner, F. M., Luciani, L. G., Tiscione, D., Malossini, G., Verze, P., Mirone, V., Bartoletti, R."Pollen extract in association with vitamins provides early pain relief in patients affected by chronic prostatitis/chronic pelvic pain syndrome". Experimental and Therapeutic Medicine 8.4 (2014): 1032-1038.
Chicago
Cai, T., Wagenlehner, F. M., Luciani, L. G., Tiscione, D., Malossini, G., Verze, P., Mirone, V., Bartoletti, R."Pollen extract in association with vitamins provides early pain relief in patients affected by chronic prostatitis/chronic pelvic pain syndrome". Experimental and Therapeutic Medicine 8, no. 4 (2014): 1032-1038. https://doi.org/10.3892/etm.2014.1861
Copy and paste a formatted citation
x
Spandidos Publications style
Cai T, Wagenlehner FM, Luciani LG, Tiscione D, Malossini G, Verze P, Mirone V and Bartoletti R: Pollen extract in association with vitamins provides early pain relief in patients affected by chronic prostatitis/chronic pelvic pain syndrome. Exp Ther Med 8: 1032-1038, 2014.
APA
Cai, T., Wagenlehner, F.M., Luciani, L.G., Tiscione, D., Malossini, G., Verze, P. ... Bartoletti, R. (2014). Pollen extract in association with vitamins provides early pain relief in patients affected by chronic prostatitis/chronic pelvic pain syndrome. Experimental and Therapeutic Medicine, 8, 1032-1038. https://doi.org/10.3892/etm.2014.1861
MLA
Cai, T., Wagenlehner, F. M., Luciani, L. G., Tiscione, D., Malossini, G., Verze, P., Mirone, V., Bartoletti, R."Pollen extract in association with vitamins provides early pain relief in patients affected by chronic prostatitis/chronic pelvic pain syndrome". Experimental and Therapeutic Medicine 8.4 (2014): 1032-1038.
Chicago
Cai, T., Wagenlehner, F. M., Luciani, L. G., Tiscione, D., Malossini, G., Verze, P., Mirone, V., Bartoletti, R."Pollen extract in association with vitamins provides early pain relief in patients affected by chronic prostatitis/chronic pelvic pain syndrome". Experimental and Therapeutic Medicine 8, no. 4 (2014): 1032-1038. https://doi.org/10.3892/etm.2014.1861
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