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Article

Pre‑ischemic exercise alleviates oxidative damage following ischemic stroke in rats

  • Authors:
    • Rui Feng
    • Min Zhang
    • Xiao Wang
    • Wen‑Bin Li
    • Shi‑Qing Ren
    • Feng Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China, Department of Pathophysiology, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China, Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China
  • Pages: 1325-1329
    |
    Published online on: July 31, 2014
       https://doi.org/10.3892/etm.2014.1874
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Abstract

Physical exercise has been proved to be neuroprotective in clinical trials and animal experiments. However, the exact mechanism underlying this neuroprotective effect remains unclear. The aim of the present study was to explore whether pre‑ischemic treadmill training could act as a form of ischemic preconditioning in a rat following ischemic stroke by reducing oxidative damage. Fifty‑four rats were randomly divided into three groups (n=18 per group): Sham surgery, middle cerebral artery occlusion (MCAO) without exercise and MCAO with exercise. Subsequent to treadmill training, ischemic stroke was induced by occluding the MCA for 1.5 h, followed by reperfusion. Six rats in each group were evaluated for neurological deficits and then sacrificed by decapitation to calculate the infarct volume. The remaining rats in each group were sacrificed to detect the level of superoxide dismutase (SOD) activity (n=6) and malondialdehyde (MDA) concentration (n=6). The results indicated that pre‑ischemic exercise training reduced brain infarct volume and neurological deficits, increased SOD activity and decreased the concentration of MDA following ischemic stroke. In conclusion, treadmill exercise training prior to MCAO/reperfusion increased the antioxidant ability and decreased the oxidative damage in the brain subsequent to ischemic stroke.
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1 

Stummer W, Baethmann A, Murr R, et al: Cerebral protection against ischemia by locomotor activity in gerbils. Underlying mechanisms. Stroke. 26:1423–1430. 1995. View Article : Google Scholar : PubMed/NCBI

2 

Ang ET, Wong PT, Moochhala S and Ng YK: Neuroprotection associated with running: is it a result of increased endogenous neurotrophic factors? Neuroscience. 118:335–345. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Endres M, Gertz K, Lindauer U, et al: Mechanisms of stroke protection by physical activity. Ann Neurol. 54:582–590. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Li J, Luan X, Clark JC, et al: Neuroprotection against transient cerebral ischemia by exercise pre-conditioning in rats. Neurol Res. 26:404–408. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Ding YH, Ding Y, Li J, et al: Exercise pre-conditioning strengthens brain microvascular integrity in a rat stroke model. Neurol Res. 28:184–189. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Zhang F, Wu Y and Jia J: Exercise preconditioning and brain ischemic tolerance. Neuroscience. 17:170–176. 2011. View Article : Google Scholar

7 

Radak Z, Toldy A, Szabo Z, et al: The effects of training and detraining on memory, neurotrophins and oxidative stress markers in rat brain. Neurochem Int. 49:387–392. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Radák Z, Kaneko T, Tahara S, et al: Regular exercise improves cognitive function and decreases oxidative damage in rat brain. Neurochem Int. 38:17–23. 2001.PubMed/NCBI

9 

Somani SM, Ravi R and Rybak LP: Effect of exercise training on antioxidant system in brain regions of rat. Pharmacol Biochem Behav. 50:635–639. 1995. View Article : Google Scholar : PubMed/NCBI

10 

Somani SM and Husain K: Interaction of exercise training and chronic ethanol ingestion on antioxidant system of rat brain regions. J Appl Toxicol. 17:329–336. 1997. View Article : Google Scholar : PubMed/NCBI

11 

Lappalainen Z, Lappalainen J, Oksala NK, et al: Diabetes impairs exercise training-associated thioredoxin response and glutathione status in rat brain. J Appl Physiol (1985). 106:461–467. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Bromont C, Marie C and Bralet J: Increased lipid peroxidation in vulnerable brain regions after transient forebrain ischemia in rats. Stroke. 20:918–924. 1989. View Article : Google Scholar : PubMed/NCBI

13 

Kondo Y, Asanuma M, Nishibayashi S, et al: Late-onset lipid peroxidation and neuronal cell death following transient forebrain ischemia in rat brain. Brain Res. 772:37–44. 1997. View Article : Google Scholar : PubMed/NCBI

14 

Re G, Azzimondi G, Lanzarini C, et al: Plasma lipoperoxidative markers in ischaemic stroke suggest brain embolism. Eur J Emerg Med. 4:5–9. 1997.PubMed/NCBI

15 

Hamakawa M, Ishida A, Tamakoshi K, et al: Repeated short-term daily exercise ameliorates oxidative cerebral damage and the resultant motor dysfunction after transient ischemia in rats. J Clin Biochem Nutr. 53:8–14. 2013. View Article : Google Scholar

16 

Longa EZ, Weinstein PR, Carlson S and Cummins R: Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 20:84–91. 1989. View Article : Google Scholar : PubMed/NCBI

17 

Oyanagui Y: Reevaluation of assay methods and establishment of kit for superoxide dismutase activity. Anal Biochem. 142:290–296. 1984. View Article : Google Scholar : PubMed/NCBI

18 

Giannopolitis CN and Ries SK: Superoxide dismutases: I. Occurrence in higher plants. Plant Physiol. 59:309–314. 1977. View Article : Google Scholar : PubMed/NCBI

19 

Ohkawa H, Ohishi N and Yagi K: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 95:351–358. 1979. View Article : Google Scholar : PubMed/NCBI

20 

National Center for Health Statistics (US). Health, United States, 2010: With Special Feature on Death and Dying. Public Health Service. Report no. 2011–1232. US Department of Health and Human Services; Hyattsville, MD: 2011

21 

Krarup LH, Truelsen T, Gluud C, et al: Prestroke physical activity is associated with severity and long-term outcome from first-ever stroke. Neurology. 71:1313–1318. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Deplanque D, Masse I, Lefebvre C, et al: Prior TIA, lipid-lowering drug use, and physical activity decrease ischemic stroke severity. Neurology. 67:1403–1410. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Sacco RL, Gan R, Boden-Albala B, et al: Leisure-time physical activity and ischemic stroke risk: the Northern Manhattan Stroke Study. Stroke. 29:380–387. 1998. View Article : Google Scholar : PubMed/NCBI

24 

Stroud N, Mazwi TM, Case LD, et al; Ischemic Stroke Genetics Study Investigators. Prestroke physical activity and early functional status after stroke. J Neurol Neurosurg Psychiatry. 80:1019–1022. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Rist PM, Lee IM, Kase CS, et al: Physical activity and functional outcomes from cerebral vascular events in men. Stroke. 42:3352–3356. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Guo M, Cox B, Mahale S, et al: Pre-ischemic exercise reduces matrix metalloproteinase-9 expression and ameliorates blood-brain barrier dysfunction in stroke. Neuroscience. 151:340–351. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Ding Y, Li J, Luan X, et al: Exercise pre-conditioning reduces brain damage in ischemic rats that may be associated with regional angiogenesis and cellular overexpression of neurotrophin. Neuroscience. 124:583–591. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Ding YH, Li J, Yao WX, et al: Exercise preconditioning upregulates cerebral integrins and enhances cerebrovascular integrity in ischemic rats. Acta Neuropathol. 112:74–84. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Zhang F, Jia J, Wu Y, et al: The effect of treadmill training pre-exercise on glutamate receptor expression in rats after cerebral ischemia. Int J Mol Sci. 11:2658–2669. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Zhang F, Wu Y, Jia J and Hu YS: Pre-ischemic treadmill training induces tolerance to brain ischemia: involvement of glutamate and ERK1/2. Molecules. 15:5246–5257. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Cheeseman KH and Slater TF: An introduction to free radical biochemistry. Br Med Bull. 49:481–493. 1993.PubMed/NCBI

32 

Esterbauer H: Estimation of peroxidative damage. A critical review. Pathol Biol (Paris). 44:25–28. 1996.PubMed/NCBI

33 

Romero FJ, Bosch-Morell F, Romero MJ, et al: Lipid peroxidation products and antioxidants in human disease. Environ Health Perspect. 106(Suppl 5): 1229–1234. 1998. View Article : Google Scholar : PubMed/NCBI

34 

Radak Z, Kumagai S, Taylor AW, et al: Effects of exercise on brain function: role of free radicals. Appl Physiol Nutr Metab. 32:942–946. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Feng R, Zhang M, Wang X, Li WB, Ren SQ and Zhang F: Pre‑ischemic exercise alleviates oxidative damage following ischemic stroke in rats. Exp Ther Med 8: 1325-1329, 2014.
APA
Feng, R., Zhang, M., Wang, X., Li, W., Ren, S., & Zhang, F. (2014). Pre‑ischemic exercise alleviates oxidative damage following ischemic stroke in rats. Experimental and Therapeutic Medicine, 8, 1325-1329. https://doi.org/10.3892/etm.2014.1874
MLA
Feng, R., Zhang, M., Wang, X., Li, W., Ren, S., Zhang, F."Pre‑ischemic exercise alleviates oxidative damage following ischemic stroke in rats". Experimental and Therapeutic Medicine 8.4 (2014): 1325-1329.
Chicago
Feng, R., Zhang, M., Wang, X., Li, W., Ren, S., Zhang, F."Pre‑ischemic exercise alleviates oxidative damage following ischemic stroke in rats". Experimental and Therapeutic Medicine 8, no. 4 (2014): 1325-1329. https://doi.org/10.3892/etm.2014.1874
Copy and paste a formatted citation
x
Spandidos Publications style
Feng R, Zhang M, Wang X, Li WB, Ren SQ and Zhang F: Pre‑ischemic exercise alleviates oxidative damage following ischemic stroke in rats. Exp Ther Med 8: 1325-1329, 2014.
APA
Feng, R., Zhang, M., Wang, X., Li, W., Ren, S., & Zhang, F. (2014). Pre‑ischemic exercise alleviates oxidative damage following ischemic stroke in rats. Experimental and Therapeutic Medicine, 8, 1325-1329. https://doi.org/10.3892/etm.2014.1874
MLA
Feng, R., Zhang, M., Wang, X., Li, W., Ren, S., Zhang, F."Pre‑ischemic exercise alleviates oxidative damage following ischemic stroke in rats". Experimental and Therapeutic Medicine 8.4 (2014): 1325-1329.
Chicago
Feng, R., Zhang, M., Wang, X., Li, W., Ren, S., Zhang, F."Pre‑ischemic exercise alleviates oxidative damage following ischemic stroke in rats". Experimental and Therapeutic Medicine 8, no. 4 (2014): 1325-1329. https://doi.org/10.3892/etm.2014.1874
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