Interdependency of selected metabolic variables in an animal model of metabolic syndrome

Mellouk,Zoheir; Sener,Abdullah; Ait Yahia,Dalila; Malaisse,Willy  J.

doi:10.3892/etm.2014.1886

Interdependency of selected metabolic variables in an animal model of metabolic syndrome

Authors:
- Zoheir Mellouk
- Abdullah Sener
- Dalila Ait Yahia
- Willy J. Malaisse
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Affiliations: Department of Biology, Es‑Sénia University, Oran, Algeria, Laboratory of Experimental Hormonology, Université Libre de Bruxelles, Brussels, Belgium
Published online on: August 6, 2014 https://doi.org/10.3892/etm.2014.1886
Pages: 1275-1278

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Abstract

In the present study, the correlation between the percentage of glycated hemoglobin, taken as representative of changes in glucose homeostasis, and selected variables was investigated. Rats were treated for 8 weeks with diets containing 64% starch and 5% sunflower oil or containing 64% D‑fructose mixed with: 5% sunflower oil; 3.4% sunflower oil and 1.6% salmon oil; or 3.4% sunflower oil and 1.6% safflower oil. Positive correlations were found between glycated hemoglobin and plasma albumin, urea, creatinine, phospholipids, triglycerides and total cholesterol, liver cholesterol, triglyceride and phospholipid content, and the plasma, liver, heart, kidney, soleus muscle and visceral adipose tissue content of thiobarbituric acid reactive substances, carbonyl derivatives and hydroperoxides. Inversely, negative correlations were observed between glycated hemoglobin and plasma calcium, iron and HDL‑cholesterol concentrations, liver, heart, kidney, soleus muscle and visceral adipose tissue superoxide dismutase and catalase activity; as well as plasma, liver, heart, kidney, soleus muscle and visceral adipose tissue nitric oxide content. Only the liver glucokinase activity and liver, heart, kidney, soleus muscle and visceral adipose tissue glutathione reductase activity failed to display a significant correlation with glycated hemoglobin. These findings confirm the hypothesis that there is a close association between glucose homeostasis and other variables when considering the effects of long‑chain polyunsaturated ω3 and ω6 fatty acids in rats with fructose‑induced metabolic syndrome.

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1	Boukortt FO, Madani Z, Mellouk Z, Louchami K, Sener A and Ait Yahia D: Nutritional factors and fructose-induced metabolic syndrome. Metab Funct Res Diab. 4:18–34. 2011.
2	Cancelas J, Prieto PG, Villanueva-Peñacarrillo ML, Zhang Y, Portois L, Sener A, Carpentier YA, Valverde I and Malaisse WJ: Glucose intolerance associated to insulin resistance and increased insulin secretion in rats depleted in long-chain polyunsaturated ω3 fatty acids. Horm Metab Res. 39:823–825. 2007.PubMed/NCBI
3	Prieto PG, Cancelas J, Moreno P, Villanueva-Peñacarrillo ML, Malaisse WJ and Valverde I: Effect of diet supplementation with olive oil and guar upon fructose-induced insulin resistance in normal rats. Endocrine. 31:294–299. 2007. View Article : Google Scholar : PubMed/NCBI
4	Mellouk Z, Hachimi Idrissi T, Louchami K, Hupkens E, Malaisse WJ, Ait Yahia D and Sener A: The metabolic syndrome of fructose-fed rats: Effects of long-chain polyunsaturated ω3 and ω6 fatty acids. I Intraperitoneal glucose tolerance test. Int J Mol Med. 28:1087–1092. 2011.
5	Mellouk Z, Hachimi Idrissi T, Louchami K, Hupkens E, Sener A, Ait Yahia D and Malaisse WJ: The metabolic syndrome of fructose-fed rats: Effects of long-chain polyunsaturated ω3 and ω6 fatty acids. II Time course of changes in food intake, body weight, plasma glucose and insulin concentrations and insulin resistance. Int J Mol Med. 29:113–118. 2012.
6	Mellouk Z, Zhang Y, Bulur N, Louchami K, Malaisse WJ, Ait Yahia D and Sener A: The metabolic syndrome of fructose-fed rats: Effects of long-chain polyunsaturated ω3 and ω6 fatty acids. III Secretory behaviour of isolated pancreatic islets. Int J Mol Med. 29:285–290. 2012.
7	Mellouk Z, Zhang Y, Bulur N, Louchami K, Malaisse WJ, Ait Yahia D and Sener A: The metabolic syndrome of fructose-fed rats: Effects of long-chain polyunsaturated ω3 and ω6 fatty acids. III Secretory behaviour of isolated pancreatic islets. Int J Mol Med. 29:285–290. 2012.
8	Mellouk Z, Louchami K, Hupkens E, Sener A, Ait Yahia D and Malaisse WJ: The metabolic syndrome of fructose-fed rats: effects of long-chain polyunsaturated ω3 and ω6 fatty acids. V Post-mortem findings. Mol Med Reports. 6:1399–1403. 2012.
9	Mellouk Z, Hupkens E, Antoine M-H, Sener A, Ait Yahia D and Malaisse WJ: The metabolic syndrome of fructose-fed rats: Effects of long-chain polyunsaturated ω3 and ω6 fatty acids. VI Further post-mortem investigations. Mol Med Reports. 6:1404–1408. 2012.
10	Mellouk Z, Sener A, Ait Yahia D and Malaisse WJ: The metabolic syndrome of fructose-fed rats: Effects of long-chain polyunsaturated ω3 and ω6 fatty acids. VII Oxidative stress. Mol Med Reports. 6:1409–1412. 2012.