Therapeutic efficacy and mechanism of water‑soluble extracts of Banxiaxiexin decoction on BALB/c mice with oxazolone‑induced colitis

Wang,Xuewei; Yang,Jinghui; Cao,Qin; Tang,Jianmin

doi:10.3892/etm.2014.1890

October 2014 Volume 8 Issue 4

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October 2014 Volume 8 Issue 4

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Article

Therapeutic efficacy and mechanism of water‑soluble extracts of Banxiaxiexin decoction on BALB/c mice with oxazolone‑induced colitis

Authors:
- Xuewei Wang
- Jinghui Yang
- Qin Cao
- Jianmin Tang
View Affiliations / Copyright

Affiliations: Department of Gastroenterology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, P.R. China, Department of Pathology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, P.R. China
Pages: 1201-1204
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Published online on: August 8, 2014

https://doi.org/10.3892/etm.2014.1890
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Abstract

The aim of the present study was to investigate the therapeutic effects of water‑soluble extracts of Banxiaxiexin decoction, a classical traditional Chinese medicine formulation, on BALB/c mice with experimentally induced ulcerative colitis (UC). Water‑soluble extracts of Banxiaxiexin decoction were intragastrically administered to BALB/c mice with oxazolone (OXA)‑induced colitis. Sulfasalazine (SASP) was administered intragastrically to OXA‑treated mice to establish the SASP group (positive control). Following drug administration, the disease activity index (DAI) and the histopathological inflammation score were recorded. In addition, the expression levels of interleukin (IL)‑5 and IL‑13 mRNA in the colonic tissue were determined by fluorescent quantitative polymerase chain reaction. The DAI and histopathological inflammation score of the model group were significantly greater compared with those of the control group, and the mRNA expression levels of IL‑5 and IL‑13 in the colonic tissue were also significantly higher in the model group compared with those in the control group. The intragastric administration of water‑soluble extracts of Banxiaxiexin decoction significantly lowered the DAI and histopathological inflammation score. The mRNA expression levels of IL‑5 and IL‑13 in the colonic tissue were also significantly lowered. The therapeutic effect of Banxiaxiexin decoction was found to be comparable to that of SASP. In conclusion, the results from the present study demonstrate that water‑soluble extracts of the traditional Chinese medicine formulation Banxiaxiexin decoction have a therapeutic effect on BALB/c mice with OXA‑induced colitis.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Therapeutic efficacy and mechanism of water‑soluble extracts of Banxiaxiexin decoction on BALB/c mice with oxazolone‑induced colitis

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