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Article

Farnesoid X receptor inhibits LNcaP cell proliferation via the upregulation of PTEN

  • Authors:
    • Jun Liu
    • Shi‑Jun Tong
    • Xiang Wang
    • Lian‑Xi Qu
  • View Affiliations / Copyright

    Affiliations: Department of Urology Surgery, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, P.R. China
  • Pages: 1209-1212
    |
    Published online on: August 11, 2014
       https://doi.org/10.3892/etm.2014.1894
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Abstract

Prostate cancer is a form of cancer that develops in the prostate, a gland in the male reproductive system. In the present study, the activation of the farnesoid X receptor (FXR), a member of the nuclear receptor superfamily, was demonstrated to inhibit cell proliferation in LNcaP cells. Using clinical samples, mRNA and protein levels of FXR were found to be significantly decreased by quantitative PCR and western blot analysis in prostate cancer tissues. In vitro studies identified further that activation or overexpression of FXR suppressed prostate cancer cell proliferation as measured by BrdU incorporation assays. At the molecular level, the results further revealed that the expression of the tumor suppressor gene, PTEN, was upregulated by FXR activation. Therefore, the observations indicated that FXR functions as a tumor suppressor in prostate cancer, which may provide a novel method for molecular targeting cancer treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Liu J, Tong SJ, Wang X and Qu LX: Farnesoid X receptor inhibits LNcaP cell proliferation via the upregulation of PTEN. Exp Ther Med 8: 1209-1212, 2014.
APA
Liu, J., Tong, S., Wang, X., & Qu, L. (2014). Farnesoid X receptor inhibits LNcaP cell proliferation via the upregulation of PTEN. Experimental and Therapeutic Medicine, 8, 1209-1212. https://doi.org/10.3892/etm.2014.1894
MLA
Liu, J., Tong, S., Wang, X., Qu, L."Farnesoid X receptor inhibits LNcaP cell proliferation via the upregulation of PTEN". Experimental and Therapeutic Medicine 8.4 (2014): 1209-1212.
Chicago
Liu, J., Tong, S., Wang, X., Qu, L."Farnesoid X receptor inhibits LNcaP cell proliferation via the upregulation of PTEN". Experimental and Therapeutic Medicine 8, no. 4 (2014): 1209-1212. https://doi.org/10.3892/etm.2014.1894
Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Tong SJ, Wang X and Qu LX: Farnesoid X receptor inhibits LNcaP cell proliferation via the upregulation of PTEN. Exp Ther Med 8: 1209-1212, 2014.
APA
Liu, J., Tong, S., Wang, X., & Qu, L. (2014). Farnesoid X receptor inhibits LNcaP cell proliferation via the upregulation of PTEN. Experimental and Therapeutic Medicine, 8, 1209-1212. https://doi.org/10.3892/etm.2014.1894
MLA
Liu, J., Tong, S., Wang, X., Qu, L."Farnesoid X receptor inhibits LNcaP cell proliferation via the upregulation of PTEN". Experimental and Therapeutic Medicine 8.4 (2014): 1209-1212.
Chicago
Liu, J., Tong, S., Wang, X., Qu, L."Farnesoid X receptor inhibits LNcaP cell proliferation via the upregulation of PTEN". Experimental and Therapeutic Medicine 8, no. 4 (2014): 1209-1212. https://doi.org/10.3892/etm.2014.1894
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