Role of basophils in the pathogenesis of minimal change nephrotic syndrome: A literature review

  • Authors:
    • Qingjun Pan
    • Jing Wu
    • Jingli Tao
    • Yanwen Chen
    • Lu  Li
    • Zhenzhen  Deng
    • Weijing Liu
    • Huafeng Liu
  • View Affiliations

  • Published online on: August 12, 2014     https://doi.org/10.3892/etm.2014.1901
  • Pages: 1027-1031
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Abstract

A number of studies have verified that minimal change nephrotic syndrome (MCNS) may result from the dysfunction of T cells and B cells, although the precise mechanisms are yet to be elucidated. It is widely recognized that MCNS is a T helper (Th)2‑dominant glomerular disease caused by an imbalanced Th1/Th2 immune response. Increased levels of the Th2 cytokines, interleukin (IL)‑4 and IL‑13, have been demonstrated to be closely associated with disease activity. In addition, basophils can affect the Th1/Th2 balance by enhancing the Th2 response and impairing the Th1 response, which are then involved in the development of numerous diseases. However, whether basophils are vital in the pathogenesis of MCNS remains unknown. Frequent positivity of the human basophil degranulation test in patients with MCNS has been observed. Thus, basophils should be analyzed in order to determine their role in the pathogenesis of MCNS.
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October 2014
Volume 8 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Pan Q, Wu J, Tao J, Chen Y, Li L, Deng Z, Liu W and Liu H: Role of basophils in the pathogenesis of minimal change nephrotic syndrome: A literature review. Exp Ther Med 8: 1027-1031, 2014
APA
Pan, Q., Wu, J., Tao, J., Chen, Y., Li, L., Deng, Z. ... Liu, H. (2014). Role of basophils in the pathogenesis of minimal change nephrotic syndrome: A literature review. Experimental and Therapeutic Medicine, 8, 1027-1031. https://doi.org/10.3892/etm.2014.1901
MLA
Pan, Q., Wu, J., Tao, J., Chen, Y., Li, L., Deng, Z., Liu, W., Liu, H."Role of basophils in the pathogenesis of minimal change nephrotic syndrome: A literature review". Experimental and Therapeutic Medicine 8.4 (2014): 1027-1031.
Chicago
Pan, Q., Wu, J., Tao, J., Chen, Y., Li, L., Deng, Z., Liu, W., Liu, H."Role of basophils in the pathogenesis of minimal change nephrotic syndrome: A literature review". Experimental and Therapeutic Medicine 8, no. 4 (2014): 1027-1031. https://doi.org/10.3892/etm.2014.1901