Ossification and increased bone mineral density with zoledronic acid in a patient with lung adenocarcinoma: A case report

Kurishima,Koichi; Ohara,Gen; Kagohashi,Katsunori; Takayashiki,Norio; Tamura,Tomohiro; Shiozawa,Toshihiro; Miyazaki,Kunihiko; Kawaguchi,Mio; Satoh,Hiroaki; Hizawa,Nobuyuki

doi:10.3892/etm.2014.1914

October 2014 Volume 8 Issue 4

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

October 2014 Volume 8 Issue 4

Full Size Image

Case Report

Ossification and increased bone mineral density with zoledronic acid in a patient with lung adenocarcinoma: A case report

Authors:
- Koichi Kurishima
- Gen Ohara
- Katsunori Kagohashi
- Norio Takayashiki
- Tomohiro Tamura
- Toshihiro Shiozawa
- Kunihiko Miyazaki
- Mio Kawaguchi
- Hiroaki Satoh
- Nobuyuki Hizawa
View Affiliations / Copyright

Affiliations: Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 310‑0015, Japan, Division of Pathology, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 310‑0015, Japan, Division of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305‑8575, Japan
Pages: 1267-1270
|
Published online on: August 18, 2014

https://doi.org/10.3892/etm.2014.1914
Expand metrics +

Abstract

Cases of ossification and increased bone mineral density (BMD) at sites of bone metastasis following zoledronic acid (ZA) treatment have not been reported. The current study presents the case of a 65‑year‑old patient with lung adenocarcinoma and bone metastases in the lumbar vertebrae and femurs. Ossification and an increase in BMD at the metastatic sites was achieved following treatment with ZA and irradiation of the bone metastatic sites. The patient was able to maintain a normal lifestyle for over two years, despite the bone metastases. Therefore, as treatment with ZA was demonstrated to improve patient quality of life, physicians should consider this treatment strategy, particularly for the treatment of metastasis in weight‑bearing bones.

View Figures

View References

1	Lote K, Walløe A and Bjersand A: Bone metastasis. Prognosis, diagnosis and treatment. Acta Radiol Oncol. 25:227–232. 1986. View Article : Google Scholar : PubMed/NCBI
2	Aydinli U, Ozturk C, Bayram S, Sarihan S, Evrensel T and Yilmaz HS: Evaluation of lung cancer metastases to the spine. Acta Orthop Belg. 72:592–597. 2006.PubMed/NCBI
3	Gnant M: Bisphosphonates in the prevention of disease recurrence: current results and ongoing trials. Curr Cancer Drug Targets. 9:824–833. 2009. View Article : Google Scholar : PubMed/NCBI
4	Chang CC, Chi KH, Kao SJ, et al: Upfront gefitinib/erlotinib treatment followed by concomitant radiotherapy for advanced lung cancer: a mono-institutional experience. Lung Cancer. 73:189–194. 2011. View Article : Google Scholar : PubMed/NCBI
5	Inomata M, Shukuya T, Takahashi T, et al: Continuous administration of EGFR-TKIs following radiotherapy after disease progression in bone lesions for non-small cell lung cancer. Anticancer Res. 31:4519–4523. 2011.PubMed/NCBI
6	Takagi M, Arizumi T, Tanio Y, et al: Multidisciplinary strategy for lung cancer patients with bone metastasis. Gan To Kagaku Ryoho. 35:1783–1786. 2008.(In Japanese).
7	McKeage K and Plosker GL: Zoledronic acid: a pharmacoeconomic review of its use in the management of bone metastases. Pharmacoeconomics. 26:251–268. 2008. View Article : Google Scholar : PubMed/NCBI
8	Papapetrou PD: Bisphosphonate-associated adverse events. Hormones (Athens). 8:96–110. 2009. View Article : Google Scholar : PubMed/NCBI
9	Nakazawa K, Kurishima K, Tamura T, et al: Specific organ metastases and survival in small cell lung cancer. Oncol Lett. 4:617–620. 2012.PubMed/NCBI
10	Hirano Y, Oda M, Tsunezuka Y, Ishikawa N and Watanabe G: Long-term survival cases of lung cancer presented as solitary bone metastasis. Ann Thorac Cardiovasc Surg. 11:401–404. 2005.PubMed/NCBI
11	Taniwaki M, Kakusui M, Imoto M, Takashima T, Misawa S and Kashima K: Disease-free survival in a patient with squamous cell lung carcinoma following complete response with the combination chemotherapy of cisplatin and etoposide. Gan To Kagaku Ryoho. 20:949–952. 1993.(In Japanese).
12	Kawai S, Yamaura G, Yasuda K and Suzuki T: Remarkable regression of an osteolytic lesion of large cell lung cancer treated with zoledronic acid: a case report. Case Rep Oncol. 5:233–237. 2012. View Article : Google Scholar : PubMed/NCBI
13	Ikeda T, Nakanishi H and Hayata A: Use of zoledronic acid for lung cancer with bone metastases - a study on reossification of osteolytic bone metastases. Gan To Kagaku Ryoho. 40:871–875. 2013.(In Japanese).
14	Reid IR, Brown JP, Burckhardt P, et al: Intravenous zoledronic acid in postmenopausal women with low bone mineral density. N Engl J Med. 346:653–661. 2002. View Article : Google Scholar : PubMed/NCBI
15	Ooi HL, Briody J, McQuade M and Munns CF: Zoledronic acid improves bone mineral density in pediatric spinal cord injury. J Bone Miner Res. 27:1536–1540. 2012. View Article : Google Scholar : PubMed/NCBI
16	Panigrahi I, Das RR, Sharda S, Marwaha RK and Khandelwal N: Response to zolendronic acid in children with type III osteogenesis imperfecta. J Bone Miner Metab. 28:451–455. 2010. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Ossification and increased bone mineral density with zoledronic acid in a patient with lung adenocarcinoma: A case report

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Related Articles