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Effect of Hyssopus officinalis L. on inhibiting airway inflammation and immune regulation in a chronic asthmatic mouse model

  • Authors:
    • Xiaojuan Ma
    • Xiumin Ma
    • Zhixing Ma
    • Jing Wang
    • Zhan Sun
    • Wenyan Yu
    • Fengsen Li
    • Jianbing Ding
  • View Affiliations / Copyright

    Affiliations: Xinjiang National Clinical Research Base of Traditional Chinese Medicine, Xinjiang Medical University, Ürümqi, Xinjiang 830011, P.R. China, Department of Clinical Laboratory, First Affiliated Hospital of Xinjiang Medical University, Ürümqi, Xinjiang 830054, P.R. China, Ürümqi General Hospital of Lanzhou Military Area Command, Ürümqi, Xinjiang 830000, P.R. China, Department of Immunology, College of Basic Medicine, Ürümqi, Xinjiang 830011, P.R. China
  • Pages: 1371-1374
    |
    Published online on: September 18, 2014
       https://doi.org/10.3892/etm.2014.1978
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Abstract

The Uygur herb, Hyssopus officinalis L., has been demonstrated to affect the levels of a number of cytokines in asthmatic mice, including interleukin‑4, ‑6 and ‑17 and interferon‑γ. In the present study, the effect of Hyssopus officinalis L. on airway immune regulation and airway inflammation was investigated in a mouse model of chronic asthma. A total of 32 BALB/c mice were randomly divided into four groups, which included the normal, chronic asthmatic, dexamethasone treatment and Hyssopus officinalis L. treatment groups. Mice were sensitized and challenged with ovalbumin to establish an asthma model and the ratio of eosinophils (EOS) in the bronchoalveolar lavage fluid (BALF) was determined. In addition, the levels of immunoglobulin (Ig)E and IgG were detected using an enzyme‑linked immunosorbent assay. The degree of airway mucus secretion was observed using the periodic acid‑Schiff stain method. The results demonstrated that the ratio of EOS in the BALF and the level of serum IgE in the chronic asthmatic and dexamethasone treatment groups increased, while the level of serum IgG decreased, when compared with the normal group. In addition, excessive secretion of airway mucus was observed in these two groups. However, the EOS ratio in the BALF and the levels of serum IgE and IgG in the Hyssopus officinalis L. treatment group were similar to the results observed in the normal group. In conclusion, Hyssopus officinalis L. not only plays an anti‑inflammatory role by inhibiting the invasion of EOS and decreasing the levels of IgE, but also affects immune regulation.
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Copy and paste a formatted citation
Spandidos Publications style
Ma X, Ma X, Ma Z, Wang J, Sun Z, Yu W, Li F and Ding J: Effect of Hyssopus officinalis L. on inhibiting airway inflammation and immune regulation in a chronic asthmatic mouse model. Exp Ther Med 8: 1371-1374, 2014.
APA
Ma, X., Ma, X., Ma, Z., Wang, J., Sun, Z., Yu, W. ... Ding, J. (2014). Effect of Hyssopus officinalis L. on inhibiting airway inflammation and immune regulation in a chronic asthmatic mouse model. Experimental and Therapeutic Medicine, 8, 1371-1374. https://doi.org/10.3892/etm.2014.1978
MLA
Ma, X., Ma, X., Ma, Z., Wang, J., Sun, Z., Yu, W., Li, F., Ding, J."Effect of Hyssopus officinalis L. on inhibiting airway inflammation and immune regulation in a chronic asthmatic mouse model". Experimental and Therapeutic Medicine 8.5 (2014): 1371-1374.
Chicago
Ma, X., Ma, X., Ma, Z., Wang, J., Sun, Z., Yu, W., Li, F., Ding, J."Effect of Hyssopus officinalis L. on inhibiting airway inflammation and immune regulation in a chronic asthmatic mouse model". Experimental and Therapeutic Medicine 8, no. 5 (2014): 1371-1374. https://doi.org/10.3892/etm.2014.1978
Copy and paste a formatted citation
x
Spandidos Publications style
Ma X, Ma X, Ma Z, Wang J, Sun Z, Yu W, Li F and Ding J: Effect of Hyssopus officinalis L. on inhibiting airway inflammation and immune regulation in a chronic asthmatic mouse model. Exp Ther Med 8: 1371-1374, 2014.
APA
Ma, X., Ma, X., Ma, Z., Wang, J., Sun, Z., Yu, W. ... Ding, J. (2014). Effect of Hyssopus officinalis L. on inhibiting airway inflammation and immune regulation in a chronic asthmatic mouse model. Experimental and Therapeutic Medicine, 8, 1371-1374. https://doi.org/10.3892/etm.2014.1978
MLA
Ma, X., Ma, X., Ma, Z., Wang, J., Sun, Z., Yu, W., Li, F., Ding, J."Effect of Hyssopus officinalis L. on inhibiting airway inflammation and immune regulation in a chronic asthmatic mouse model". Experimental and Therapeutic Medicine 8.5 (2014): 1371-1374.
Chicago
Ma, X., Ma, X., Ma, Z., Wang, J., Sun, Z., Yu, W., Li, F., Ding, J."Effect of Hyssopus officinalis L. on inhibiting airway inflammation and immune regulation in a chronic asthmatic mouse model". Experimental and Therapeutic Medicine 8, no. 5 (2014): 1371-1374. https://doi.org/10.3892/etm.2014.1978
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