Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2014 Volume 8 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2014 Volume 8 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Late onset oral treatment with tranilast following large myocardial infarction has no beneficial effects on cardiac remodeling and mortality in rats

  • Authors:
    • Stefan Betge
    • Christian Kunz
    • Hans Figulla
    • Christian Jung
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine I, Division of Cardiology, Friedrich Schiller University, Jena, Thuringia 07740, Germany, Department of General, Abdominal and Thoracic Surgery, City Hospital Dessau, Dessau-RoBlau, Saxony-Anhalt 06847, Germany
  • Pages: 1789-1796
    |
    Published online on: October 6, 2014
       https://doi.org/10.3892/etm.2014.2003
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Tranilast (Tra) reduces intracardiac interstitial fibrosis in the animal models of hypertensive heart failure and diabetic cardiomyopathy by inhibiting cardiac fibroblasts. The present study examined whether Tra has long‑term effects on the cardiac remodeling in the remote area of the left ventricle (LV) following myocardial infarction (MI) in the rat. Treatment with Tra (n=40; 150 mg/kg twice daily) or placebo (Plac, n=36) was started at day 28 after induction of a large MI or sham‑operation (ShO, n=18) in female Lewis rats. Collagen content was determined using high‑performance liquid chromatography. Large MI led to a significant hypertrophy of the two ventricles, a severe dilatation of the LV and a shift of the chamber stiffness variables in the pressure volume curves. The six‑month survival rates were Tra, 62.5%; Plac, 75%; and ShO, 100%. No significant difference was identified between Tra and Plac regarding survival rate and collagen content. Treatment with the anti‑inflammatory and antifibrotic drug, Tra, started four weeks after the induction of a large MI in the rat, did not attenuate or positively influence remodeling in chronic ischemic heart failure and survival. Further studies are required to explore the effects of Tra on cardiac myocytes post‑MI in more detail.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Azuma H, Banno K and Yoshimura T: Pharmacological properties of N-(3′,4′-dimethoxycinnamoyl) anthranilic acid (N-5′), a new anti-atopic agent. Br J Pharmacol. 58:483–488. 1976.

2 

Taniguchi S, Yorifuji T and Hamada T: Treatment of linear localized scleroderma with the anti-allergic drug, tranilast. Clin Exp Dermatol. 19:391–393. 1994. View Article : Google Scholar : PubMed/NCBI

3 

Yamada H, Ide A, Sugiura M and Tajima S: Treatment of cutaneous sarcoidosis with tranilast. J Dermatol. 22:149–152. 1995.PubMed/NCBI

4 

Yamada H, Tajima S, Nishikawa T, Murad S and Pinnell SR: Tranilast, a selective inhibitor of collagen synthesis in human skin fibroblasts. J Biochem. 116:892–897. 1994.PubMed/NCBI

5 

Suzawa H, Kikuchi S, Ichikawa K and Koda A: Inhibitory action of tranilast, an anti-allergic drug, on the release of cytokines and PGE2 from human monocytes-macrophages. Jpn J Pharmacol. 60:85–90. 1992. View Article : Google Scholar : PubMed/NCBI

6 

Adachi S, Maruyama T, Kondo T, Todoroki T and Fukao K: The prevention of postoperative intraperitoneal adhesions by tranilast: N-(3′,4′-dimethoxycinnamoyl)anthranilic acid. Surg Today. 29:51–54. 1999.PubMed/NCBI

7 

Nakamura K, Irie H, Inoue M, Mitani H, Sunami H and Sano S: Factors affecting hypertrophic scar development in median sternotomy incisions for congenital cardiac surgery. J Am Coll Surg. 185:218–223. 1997. View Article : Google Scholar : PubMed/NCBI

8 

Watanabe S, Matsuda A, Suzuki Y, et al: Inhibitory mechanism of tranilast in human coronary artery smooth muscle cells proliferation, due to blockade of PDGF-BB-receptors. Br J Pharmacol. 130:307–314. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Takahashi A, Taniguchi T, Ishikawa Y and Yokoyama M: Tranilast inhibits vascular smooth muscle cell growth and intimal hyperplasia by induction of p21(waf1/cip1/sdi1) and p53. Circ Res. 84:543–550. 1999. View Article : Google Scholar : PubMed/NCBI

10 

Tamai H1, Katoh O, Suzuki S, et al: Impact of tranilast on restenosis after coronary angioplasty: tranilast restenosis following angioplasty trial (TREAT). Am Heart J. 138:968–75. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Tamai H, Katoh K, Yamaguchi T, et al: The impact of tranilast on restenosis after coronary angioplasty: the Second Tranilast Restenosis Following Angioplasty Trial (TREAT-2). Am Heart J. 143:506–513. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Holmes DR Jr, Savage M, LaBlanche JM, et al: Results of Prevention of REStenosis with Tranilast and its Outcomes (PRESTO) trial. Circulation. 106:1243–1250. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Umemura K, Kikuchi S, Suzuki Y and Nakashima M: Inhibitory effect of tranilast on hypertrophic collagen production in the spontaneously hypertensive rat heart. Jpn J Pharmacol. 78:161–167. 1998. View Article : Google Scholar : PubMed/NCBI

14 

Kagitani S, Ueno H, Hirade S, Takahashi T, Takata M and Inoue H: Tranilast attenuates myocardial fibrosis in association with suppression of monocyte/macrophage infiltration in DOCA/salt hypertensive rats. J Hypertens. 22:1007–1015. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Bujak M and Frangogiannis NG: The role of TGF-beta signaling in myocardial infarction and cardiac remodeling. Cardiovasc Res. 74:184–195. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Dewald O, Ren G, Duerr GD, et al: Of mice and dogs: species-specific differences in the inflammatory response following myocardial infarction. Am J Pathol. 164:665–677. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Cohn JN, Ferrari R and Sharpe N: Cardiac remodeling - concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling. J Am Coll Cardiol. 35:569–582. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Ikeuchi M, Tsutsui H, Shiomi T, et al: Inhibition of TGF-beta signaling exacerbates early cardiac dysfunction but prevents late remodeling after infarction. Cardiovasc Res. 64:526–535. 2004. View Article : Google Scholar : PubMed/NCBI

19 

See F, Watanabe M, Kompa AR, et al: Early and delayed tranilast treatment reduces pathological fibrosis following myocardial infarction. Heart Lung Circ. Sept.14–2012.(Epub ahead of print).

20 

Jung C, Gonon AT, Sjöquist PO, Lundberg JO and Pernow J: Arginase inhibition mediates cardioprotection during ischaemia-reperfusion. Cardiovasc Res. 85:147–154. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Pfeffer MA, Pfeffer JM, Fishbein MC, Fletcher PJ, Spadaro J, Kloner RA and Braunwald E: Myocardial infarct size and ventricular function in rats. Circ Res. 44:503–512. 1979. View Article : Google Scholar : PubMed/NCBI

22 

Fletcher PJ, Pfeffer JM, Pfeffer MA and Braunwald E: Left ventricular diastolic pressure-volume relations in rats with healed myocardial infarction. Effects on systolic function. Circ Res. 49:618–626. 1981.PubMed/NCBI

23 

Carluccio E, Biagioli P, Alunni G, et al: Patients with hibernating myocardium show altered left ventricular volumes and shape, which revert after revascularization: evidence that dyssynergy might directly induce cardiac remodeling. J Am Coll Cardiol. 47:969–977. 2006.

24 

Bax JJ, Schinkel AF, Boersma E, et al: Extensive left ventricular remodeling does not allow viable myocardium to improve in left ventricular ejection fraction after revascularization and is associated with worse long-term prognosis. Circulation. 110:II18–II22. 2004.PubMed/NCBI

25 

Senior R, Lahiri A and Kaul S: Effect of revascularization on left ventricular remodeling in patients with heart failure from severe chronic ischemic left ventricular dysfunction. Am J Cardiol. 88:624–629. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Brown EJ Jr, Kloner RA, Schoen FJ, Hammerman H, Hale S and Braunwald E: Scar thinning due to ibuprofen administration after experimental myocardial infarction. Am J Cardiol. 51:877–883. 1983. View Article : Google Scholar : PubMed/NCBI

27 

Bulkley BH and Roberts WC: Steroid therapy during acute myocardial infarction. A cause of delayed healing and of ventricular aneurysm. Am J Med. 56:244–250. 1974. View Article : Google Scholar

28 

Weber KT, Sun Y and Cleutjens JP: Structural remodeling of the infarcted rat heart. EXS. 76:489–499. 1996.PubMed/NCBI

29 

Betge S, Lutz K, Roskos M and Figulla HR: Oral treatment with probucol in a pharmacological dose has no beneficial effects on mortality in chronic ischemic heart failure after large myocardial infarction in rats. Eur J Pharmacol. 558:119–127. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Karatas A, Hegner B, de Windt LJ, et al: Deoxycorticosterone acetate-salt mice exhibit blood pressure-independent sexual dimorphism. Hypertension. 51:1177–1183. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Tyagi P, Tyagi V, Yoshimura N, et al: Gender-based reciprocal expression of transforming growth factor-beta1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide-induced cystitis. J Inflamm (Lond). 6:232009. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Betge S, Kunz C, Figulla H and Jung C: Late onset oral treatment with tranilast following large myocardial infarction has no beneficial effects on cardiac remodeling and mortality in rats. Exp Ther Med 8: 1789-1796, 2014.
APA
Betge, S., Kunz, C., Figulla, H., & Jung, C. (2014). Late onset oral treatment with tranilast following large myocardial infarction has no beneficial effects on cardiac remodeling and mortality in rats. Experimental and Therapeutic Medicine, 8, 1789-1796. https://doi.org/10.3892/etm.2014.2003
MLA
Betge, S., Kunz, C., Figulla, H., Jung, C."Late onset oral treatment with tranilast following large myocardial infarction has no beneficial effects on cardiac remodeling and mortality in rats". Experimental and Therapeutic Medicine 8.6 (2014): 1789-1796.
Chicago
Betge, S., Kunz, C., Figulla, H., Jung, C."Late onset oral treatment with tranilast following large myocardial infarction has no beneficial effects on cardiac remodeling and mortality in rats". Experimental and Therapeutic Medicine 8, no. 6 (2014): 1789-1796. https://doi.org/10.3892/etm.2014.2003
Copy and paste a formatted citation
x
Spandidos Publications style
Betge S, Kunz C, Figulla H and Jung C: Late onset oral treatment with tranilast following large myocardial infarction has no beneficial effects on cardiac remodeling and mortality in rats. Exp Ther Med 8: 1789-1796, 2014.
APA
Betge, S., Kunz, C., Figulla, H., & Jung, C. (2014). Late onset oral treatment with tranilast following large myocardial infarction has no beneficial effects on cardiac remodeling and mortality in rats. Experimental and Therapeutic Medicine, 8, 1789-1796. https://doi.org/10.3892/etm.2014.2003
MLA
Betge, S., Kunz, C., Figulla, H., Jung, C."Late onset oral treatment with tranilast following large myocardial infarction has no beneficial effects on cardiac remodeling and mortality in rats". Experimental and Therapeutic Medicine 8.6 (2014): 1789-1796.
Chicago
Betge, S., Kunz, C., Figulla, H., Jung, C."Late onset oral treatment with tranilast following large myocardial infarction has no beneficial effects on cardiac remodeling and mortality in rats". Experimental and Therapeutic Medicine 8, no. 6 (2014): 1789-1796. https://doi.org/10.3892/etm.2014.2003
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team