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Article

Neonatal incontinentia pigmenti: Six cases and a literature review

  • Authors:
    • Yang Yang
    • Yan Guo
    • Ying Ping
    • Xiao‑Guang Zhou
    • Yong Li
  • View Affiliations / Copyright

    Affiliations: Department of Neonates, Nanjing Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China
  • Pages: 1797-1806
    |
    Published online on: October 9, 2014
       https://doi.org/10.3892/etm.2014.2011
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Abstract

The aim of this study was to retrospectively analyze the cases of six infants with incontinentia pigmenti (IP) in the Department of Neonates and compare their data with 60 cases of IP reported in the available Chinese literature, in order to determine the clinical characteristics and outcomes of neonatal IP in China. The majority of the cases were located near the eastern and southern coasts of China, and ~98.5% of IP cases occurred within 1 week of birth. The majority of the babies with IP were term infants. Twelve cases had a positive family history of IP. The mothers of 10 patients had a history of recurrent spontaneous abortions, and the mothers of five patients had infectious or autoimmune diseases during pregnancy. Cutaneous manifestations were shown at stage I in 59 cases, at stage II in 28 cases and at stage III in three cases (multiple stages were recorded in certain cases). Neurological changes occurred in 18 cases and ocular changes were observed in 12 cases. The toxoplasmosis, rubella, cytomegalovirus and herpes simplex (TORCH) test showed positive results in three cases; autoantibody positivity was found in three cases and high blood eosinophil levels were observed in 20 cases. Brain scans revealed positive results in 16 cases and complications were observed in 21 cases. Thirty‑four cases were followed for 1‑6 months, six cases for 7‑12 months and 17 cases for 13‑84 months. Among these cases, 34 exhibited no evidence of recurrence. Five patients, including one male, succumbed in the long course of the follow‑up. Two IP cases persisted after five years of follow‑up. The data from the present study may reflect the characteristics of IP in the Chinese population and provide useful information for the diagnosis and treatment of IP by dermatologists and neonatologists.
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Copy and paste a formatted citation
Spandidos Publications style
Yang Y, Guo Y, Ping Y, Zhou XG and Li Y: Neonatal incontinentia pigmenti: Six cases and a literature review. Exp Ther Med 8: 1797-1806, 2014.
APA
Yang, Y., Guo, Y., Ping, Y., Zhou, X., & Li, Y. (2014). Neonatal incontinentia pigmenti: Six cases and a literature review. Experimental and Therapeutic Medicine, 8, 1797-1806. https://doi.org/10.3892/etm.2014.2011
MLA
Yang, Y., Guo, Y., Ping, Y., Zhou, X., Li, Y."Neonatal incontinentia pigmenti: Six cases and a literature review". Experimental and Therapeutic Medicine 8.6 (2014): 1797-1806.
Chicago
Yang, Y., Guo, Y., Ping, Y., Zhou, X., Li, Y."Neonatal incontinentia pigmenti: Six cases and a literature review". Experimental and Therapeutic Medicine 8, no. 6 (2014): 1797-1806. https://doi.org/10.3892/etm.2014.2011
Copy and paste a formatted citation
x
Spandidos Publications style
Yang Y, Guo Y, Ping Y, Zhou XG and Li Y: Neonatal incontinentia pigmenti: Six cases and a literature review. Exp Ther Med 8: 1797-1806, 2014.
APA
Yang, Y., Guo, Y., Ping, Y., Zhou, X., & Li, Y. (2014). Neonatal incontinentia pigmenti: Six cases and a literature review. Experimental and Therapeutic Medicine, 8, 1797-1806. https://doi.org/10.3892/etm.2014.2011
MLA
Yang, Y., Guo, Y., Ping, Y., Zhou, X., Li, Y."Neonatal incontinentia pigmenti: Six cases and a literature review". Experimental and Therapeutic Medicine 8.6 (2014): 1797-1806.
Chicago
Yang, Y., Guo, Y., Ping, Y., Zhou, X., Li, Y."Neonatal incontinentia pigmenti: Six cases and a literature review". Experimental and Therapeutic Medicine 8, no. 6 (2014): 1797-1806. https://doi.org/10.3892/etm.2014.2011
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