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Article

Chromodomain helicase/ATPase DNA binding protein 1‑like protein expression predicts poor prognosis in nasopharyngeal carcinoma

  • Authors:
    • Fa‑Ren Su
    • Jing‑Hua Ding
    • Lin Bo
    • Xin‑Gang Liu
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology and Head and Neck Surgery, Shandong People's Armed Police Corps Hospital, Jinan, Shandong 250014, P.R. China
  • Pages: 1745-1750
    |
    Published online on: October 13, 2014
       https://doi.org/10.3892/etm.2014.2017
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Abstract

Nasopharyngeal carcinoma (NPC) is a malignancy with a high metastatic ability. Recent studies have implicated the role of chromodomain helicase/ATPase DNA binding protein 1‑like (CHD1L) gene as a novel oncogene; however, the functional role of CHD1L in NPC remains unknown. The aim of this study was to evaluate the clinical significance of CHD1L positivity in NPC. CHD1L protein expression was examined by performing western blot analysis of 30 fresh NPC tissues and conducting immunohistochemistry tests of 133 NPC samples between December 1, 2005 and December 1, 2009. The correlations of CHD1L expression status with clinicopathological features and prognosis were investigated. Immunohistochemical analysis showed that 88 of 133 (66.2%) paraffin‑embedded NPC biopsies exhibited positive expression of CHD1L, but all non‑cancerous nasopharyngeal specimens were negative for CHD1L expression. In addition, positive CHD1L expression was strongly associated with an advanced clinical stage (P=0.016), recurrence (P=0.002) and the metastasis status (P=0.031) of NPC. Kaplan‑Meier survival analysis demonstrated that patients with CHD1L‑positive NPC had significantly shorter overall survival (P<0.001). Furthermore, the multivariate analysis indicated that CHD1L protein expression was an independent prognostic factor for overall survival (hazard ratio, 7.916; 95% confidence interval, 2.067‑16.034; P=0.003) in patients with NPC. These results indicate that CHD1L is a prognostic marker for NPC.
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1 

Wei KR, Xu Y, Liu J, Zhang WJ and Liang ZH: Histopathological classification of nasopharyngeal carcinoma (Review). Asian Pac J Cancer Prev. 12:1141–1147. 2011.

2 

Zhen Y, Ye Y, Yu X, Mai C, Zhou Y, Chen Y, Yang H, Lyu X, Song Y, Wu Q, Fu Q, Zhao M, Hua S, Wang H, Liu Z, Zhang Y and Fang W: Reduced CTGF expression promotes cell growth, migration, and invasion in nasopharyngeal carcinoma. PLoS One. 8:e649762013. View Article : Google Scholar : PubMed/NCBI

3 

Ho FC, Tham IW, Earnest A, Lee KM and Lu JJ: Patterns of regional lymph node metastasis of nasopharyngeal carcinoma: a meta-analysis of clinical evidence. BMC Cancer. 12:982012. View Article : Google Scholar : PubMed/NCBI

4 

Jia WH and Qin HD: Non-viral environmental risk factors for nasopharyngeal carcinoma: a systematic review. Semin Cancer Biol. 22:117–126. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Isinger-Ekstrand A, Johansson J, Ohlsson M, Francis P, Staaf J, Jönsson M, Borg A and Nilbert M: Genetic profiles of gastroesophageal cancer: combined analysis using expression array and tiling array - comparative genomic hybridization. Cancer Genet Cytogenet. 200:120–126. 2010. View Article : Google Scholar

6 

Gottschalk AJ, Timinszky G, Kong SE, Jin J, Cai Y, Swanson SK, Washburn MP, Florens L, Ladurner AG, Conaway JW and Conaway RC: Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler. Proc Natl Acad Sci USA. 106:13770–13774. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Kokavec J, Podskocova J, Zavadil J and Stopka T: Chromatin remodeling and SWI/SNF2 factors in human disease. Front Biosci. 13:6126–6134. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Ma NF, Hu L, Fung JM, Xie D, Zheng BJ, Chen L, Tang DJ, Fu L, Wu Z, Chen M, Fang Y and Guan XY: Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma. Hepatology. 47:503–510. 2008.

9 

Chen L, Chan TH, Yuan YF, Hu L, Huang J, Ma S, Wang J, Dong SS, Tang KH, Xie D, Li Y and Guan XY: CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients. J Clin Invest. 120:1178–1191. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Chen L, Yuan YF, Li Y, Chan TH, Zheng BJ, Huang J and Guan XY: Clinical significance of CHD1L in hepatocellular carcinoma and therapeutic potentials of virus-mediated CHD1L depletion. Gut. 60:534–543. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Chung MS, Lee SH, Lee DH and Chung BH: Evaluation of the 7th American Joint Committee on cancer TNM staging system for prostate cancer in point of classification of bladder neck invasion. Jpn J Clin Oncol. 43:184–188. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Cheng W, Su Y and Xu F: CHD1L: a novel oncogene. Mol Cancer. 12:1702013. View Article : Google Scholar : PubMed/NCBI

13 

He WP, Zhou J, Cai MY, Xiao XS, Liao YJ, Kung HF, Guan XY, Xie D and Yang GF: CHD1L protein is overexpressed in human ovarian carcinomas and is a novel predictive biomarker for patients survival. BMC Cancer. 12:4372012. View Article : Google Scholar : PubMed/NCBI

14 

Li Y, Chen L, Chan TH, Liu M, Kong KL, Qiu JL, Li Y, Yuan YF and Guan XY: SPOCK1 is regulated by CHD1L and blocks apoptosis and promotes HCC cell invasiveness and metastasis in mice. Gastroenterology. 144:179–191.e4. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Ji X, Li J, Zhu L, Cai J, Zhang J, Qu Y, Zhang H, Liu B, Zhao R and Zhu Z: CHD1L promotes tumor progression and predicts survival in colorectal carcinoma. J Surg Res. 185:84–91. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Tian F, Xu F, Zhang ZY, Ge JP, Wei ZF, Xu XF and Cheng W: Expression of CHD1L in bladder cancer and its influence on prognosis and survival. Tumour Biol. 34:3687–3690. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Su FR, Ding JH, Bo L and Liu XG: Chromodomain helicase/ATPase DNA binding protein 1‑like protein expression predicts poor prognosis in nasopharyngeal carcinoma. Exp Ther Med 8: 1745-1750, 2014.
APA
Su, F., Ding, J., Bo, L., & Liu, X. (2014). Chromodomain helicase/ATPase DNA binding protein 1‑like protein expression predicts poor prognosis in nasopharyngeal carcinoma. Experimental and Therapeutic Medicine, 8, 1745-1750. https://doi.org/10.3892/etm.2014.2017
MLA
Su, F., Ding, J., Bo, L., Liu, X."Chromodomain helicase/ATPase DNA binding protein 1‑like protein expression predicts poor prognosis in nasopharyngeal carcinoma". Experimental and Therapeutic Medicine 8.6 (2014): 1745-1750.
Chicago
Su, F., Ding, J., Bo, L., Liu, X."Chromodomain helicase/ATPase DNA binding protein 1‑like protein expression predicts poor prognosis in nasopharyngeal carcinoma". Experimental and Therapeutic Medicine 8, no. 6 (2014): 1745-1750. https://doi.org/10.3892/etm.2014.2017
Copy and paste a formatted citation
x
Spandidos Publications style
Su FR, Ding JH, Bo L and Liu XG: Chromodomain helicase/ATPase DNA binding protein 1‑like protein expression predicts poor prognosis in nasopharyngeal carcinoma. Exp Ther Med 8: 1745-1750, 2014.
APA
Su, F., Ding, J., Bo, L., & Liu, X. (2014). Chromodomain helicase/ATPase DNA binding protein 1‑like protein expression predicts poor prognosis in nasopharyngeal carcinoma. Experimental and Therapeutic Medicine, 8, 1745-1750. https://doi.org/10.3892/etm.2014.2017
MLA
Su, F., Ding, J., Bo, L., Liu, X."Chromodomain helicase/ATPase DNA binding protein 1‑like protein expression predicts poor prognosis in nasopharyngeal carcinoma". Experimental and Therapeutic Medicine 8.6 (2014): 1745-1750.
Chicago
Su, F., Ding, J., Bo, L., Liu, X."Chromodomain helicase/ATPase DNA binding protein 1‑like protein expression predicts poor prognosis in nasopharyngeal carcinoma". Experimental and Therapeutic Medicine 8, no. 6 (2014): 1745-1750. https://doi.org/10.3892/etm.2014.2017
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