Open Access

Extracts of black bean peel and pomegranate peel ameliorate oxidative stress‑induced hyperglycemia in mice

  • Authors:
    • Jian‑Yun Wang
    • Chuang Zhu
    • Tian‑Wei Qian
    • Hao Guo
    • Dong‑Dong Wang
    • Fan Zhang
    • Xiaoxing Yin
  • View Affiliations

  • Published online on: October 30, 2014     https://doi.org/10.3892/etm.2014.2040
  • Pages: 43-48
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Abstract

Oxidative stress has a central role in the progression of diabetes mellitus (DM), which can directly result in the injury of islet β cells and consequent hyperglycemia. The aim of the present study was to evaluate the possible protective effects of black bean peel extract (BBPE), pomegranate peel extract (PPE) and a combination of the two (PPE + BBPE) on streptozotocin‑induced DM mice. Oxidative stress was assessed by the levels of total antioxidative capability and glutathione in the serum. Fasting blood glucose and insulin levels, as well as the pancreas weight index and the histological changes in the pancreas, were also determined. The results showed that, after fours weeks of treatment with PPE, BBPE or PPE + BBPE, DM mice showed, to different degrees, a decrease in blood glucose, increases in insulin secretion and the pancreas weight index, and an increase in antioxidative activity. These changes were particularly evident in the DM mice subjected to the combined intervention strategy of PPE + BBPE. The histological findings indicated that the injury to the pancreatic islets in DM mice was also ameliorated following treatment. In conclusion, PPE and BBPE, particularly the combination of the two, have the ability to ameliorate hyperglycemia by inhibiting oxidative stress‑induced pancreatic damage; this finding may be useful in the prevention and treatment of DM.
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January-2015
Volume 9 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wang JY, Zhu C, Qian TW, Guo H, Wang DD, Zhang F and Yin X: Extracts of black bean peel and pomegranate peel ameliorate oxidative stress‑induced hyperglycemia in mice. Exp Ther Med 9: 43-48, 2015.
APA
Wang, J., Zhu, C., Qian, T., Guo, H., Wang, D., Zhang, F., & Yin, X. (2015). Extracts of black bean peel and pomegranate peel ameliorate oxidative stress‑induced hyperglycemia in mice. Experimental and Therapeutic Medicine, 9, 43-48. https://doi.org/10.3892/etm.2014.2040
MLA
Wang, J., Zhu, C., Qian, T., Guo, H., Wang, D., Zhang, F., Yin, X."Extracts of black bean peel and pomegranate peel ameliorate oxidative stress‑induced hyperglycemia in mice". Experimental and Therapeutic Medicine 9.1 (2015): 43-48.
Chicago
Wang, J., Zhu, C., Qian, T., Guo, H., Wang, D., Zhang, F., Yin, X."Extracts of black bean peel and pomegranate peel ameliorate oxidative stress‑induced hyperglycemia in mice". Experimental and Therapeutic Medicine 9, no. 1 (2015): 43-48. https://doi.org/10.3892/etm.2014.2040